中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2014年
10期
1187-1190
,共4页
杨瑞明%赖荷%沙翔垠%陈盛强%谭颖谦%刘志平%郑瑜%陈卫芳
楊瑞明%賴荷%沙翔垠%陳盛彊%譚穎謙%劉誌平%鄭瑜%陳衛芳
양서명%뢰하%사상은%진성강%담영겸%류지평%정유%진위방
尘螨,变应性结膜炎%Foxp3-924 (rs2232365)%多态性
塵螨,變應性結膜炎%Foxp3-924 (rs2232365)%多態性
진만,변응성결막염%Foxp3-924 (rs2232365)%다태성
Dust mites%Allergic conjunctivitis%Foxp3-924(deletion/ATT,rs2232365)%Polymorphisms
目的 对尘螨诱导引起变应性结膜炎的患者行Foxp3-924 (rs2232365)基因分型,探讨Foxp3-924 (rs2232365)基因与尘螨变应性结膜炎遗传易感性的相关性.方法 临床对照研究.对2007～2011年在广州医科大学附属第二医院眼科应用PCR-SSP技术为80例无亲缘关系的尘螨变应性结膜炎患者和103名无血缘关系的健康汉族人行Foxp3-924 (rs2232365)基因分型.结果 Foxp3-924位点AA基因型频率在变应性结膜炎患者与正常对照组相比差异无统计学意义[32.5％ (26/80) vs.23.3％ (24/103),x 2=1.92,P＞0.05);GA基因型在变应性结膜炎患者中的频率显著高于正常对照组,差异有统计学意义(x2=4.82,P＜0.05).GG基因型在变应性结膜炎患者中的频率显著低于正常对照组,差异有统计学意义(x2=11.78,P＜0.01).与正常人相比,Foxp3-924 A等位基因频率显著上升,G等位基因下降,差异有统计学意义(x2=9.77,P＜0.01).结论 Foxp3-924位点基因多态性与变应性结膜炎显著相关.
目的 對塵螨誘導引起變應性結膜炎的患者行Foxp3-924 (rs2232365)基因分型,探討Foxp3-924 (rs2232365)基因與塵螨變應性結膜炎遺傳易感性的相關性.方法 臨床對照研究.對2007～2011年在廣州醫科大學附屬第二醫院眼科應用PCR-SSP技術為80例無親緣關繫的塵螨變應性結膜炎患者和103名無血緣關繫的健康漢族人行Foxp3-924 (rs2232365)基因分型.結果 Foxp3-924位點AA基因型頻率在變應性結膜炎患者與正常對照組相比差異無統計學意義[32.5％ (26/80) vs.23.3％ (24/103),x 2=1.92,P＞0.05);GA基因型在變應性結膜炎患者中的頻率顯著高于正常對照組,差異有統計學意義(x2=4.82,P＜0.05).GG基因型在變應性結膜炎患者中的頻率顯著低于正常對照組,差異有統計學意義(x2=11.78,P＜0.01).與正常人相比,Foxp3-924 A等位基因頻率顯著上升,G等位基因下降,差異有統計學意義(x2=9.77,P＜0.01).結論 Foxp3-924位點基因多態性與變應性結膜炎顯著相關.
목적 대진만유도인기변응성결막염적환자행Foxp3-924 (rs2232365)기인분형,탐토Foxp3-924 (rs2232365)기인여진만변응성결막염유전역감성적상관성.방법 림상대조연구.대2007～2011년재엄주의과대학부속제이의원안과응용PCR-SSP기술위80례무친연관계적진만변응성결막염환자화103명무혈연관계적건강한족인행Foxp3-924 (rs2232365)기인분형.결과 Foxp3-924위점AA기인형빈솔재변응성결막염환자여정상대조조상비차이무통계학의의[32.5％ (26/80) vs.23.3％ (24/103),x 2=1.92,P＞0.05);GA기인형재변응성결막염환자중적빈솔현저고우정상대조조,차이유통계학의의(x2=4.82,P＜0.05).GG기인형재변응성결막염환자중적빈솔현저저우정상대조조,차이유통계학의의(x2=11.78,P＜0.01).여정상인상비,Foxp3-924 A등위기인빈솔현저상승,G등위기인하강,차이유통계학의의(x2=9.77,P＜0.01).결론 Foxp3-924위점기인다태성여변응성결막염현저상관.
Objective To investigate the distribution of Foxp3-924(rs2232365)genes in a Guangdong population and to explore the association of these genes with allergic conjunctivitis.Methods A total of 103 unrelated healthy individuals of Han nationality and 80 patients with allergic conjunctivitis who were from the same geographic region were enrolled in the study.Foxp3-924(rs2232365) was genotyped by PCR-SSP technique.Results There was no significant difference of Foxp3-924 AA genotype frequencies between the patients with allergic conjunctivitis and the normal control group(32.5％ vs.23.3％,x2=1.92,P ＞0.05).The frequencies of GA genotype in the patients with allergic conjunctivitis were significantly higher than the normal control group(x2=4.82,P ＜0.05).And the frequencies of GG genotype in the patients with allergic conjunctivitis were significantly lower than the normal control group(x2=11.78,P ＜0.01).Compared to the normal control group,the frequencies of Foxp3-924 A allele were significantly increased while the G allele was reduced significantly(x2=9.77,P ＜0.01).Conclusions Foxp3-924(rs2232365)is associated with allergic conjunctivitis.
