CAJ | 학술논문

目的探讨影响T4a期胃癌根治术后患者远期生存和复发的因素.方法回顾性分析1997年1月至2003年12月间天津医科大学附属肿瘤医院收治的280例T4a期胃癌根治术患者的临床和随访资料.结果 280例患者术后5年生存率为50.0％;术后复发158例(56.4％),3年无瘤生存率为57.5％.多因素分析显示,淋巴结转移数目和淋巴结转移率(MLR)是影响术后患者总体生存期的独立因素(均P＜0.05);淋巴结转移范围是影响术后无病生存期的独立因素(P＜0.05)；淋巴结转移范围、淋巴结转移数目和MLR是影响术后复发的独立因素(均P＜0.05).结论淋巴结转移数目、范围和MLR是影响T4a期胃癌患者根治术后远期生存和复发的主要因素.
목적 탐토영향T4a기위암근치술후환자원기생존화복발적인소.방법 회고성분석1997년1월지2003년12월간천진의과대학부속종류의원수치적280례T4a기위암근치술환자적림상화수방자료.결과 280례환자술후5년생존솔위50.0％;술후복발158례(56.4％),3년무류생존솔위57.5％.다인소분석현시,림파결전이수목화림파결전이솔(MLR)시영향술후환자총체생존기적독립인소(균P＜0.05);림파결전이범위시영향술후무병생존기적독립인소(P＜0.05)；림파결전이범위、림파결전이수목화MLR시영향술후복발적독립인소(균P＜0.05).결론 림파결전이수목、범위화MLR시영향T4a기위암환자근치술후원기생존화복발적주요인소.
Objective To evaluate the predicators of survival and recurrence after curative resection for gastric cancer patients with serosal invasion.Methods Clinical and follow-up data of 280 patients with T4a gastric cancer (according to the 7th UICC TNM Classification for gastric cancer) who underwent curative resection for gastric cancer between January 1997 and December 2003 were analyzed retrospectively.Results Five-year survival rate of these 280 patients was 50.0％ and 158 patients (56.4％) presented with recurrence after surgery.The 3-year disease-free survival rate was 57.5％.The number of lymph node metastasis and metastatic lymph node ratio (MLR) were identified as the independent predicators for overall survival(P＜0.05).The extent of lymph node metastasis was identified as the independent predicators for disease free survival (P＜0.05).The extent of lymph node metastasis,the number of lymph node metastasis,and MLR were identified as the independent predicators for recurrence after surgery (P＜0.05).Conclusions The number of lymph node metastases,extent of lymph node metastasis and MLR are independent predictors of overall survival and recurrence in T4a gastric cancer patients after curative resection.