CAJ | 학술논문

目的探讨早期原发性胃弥漫大B细胞淋巴瘤(DLBCL)的预后影响因素及治疗方式的选择.方法回顾性分析天津医科大学附属肿瘤医院1993年1月至2008年8月间经胃镜活检或手术病理证实的75例早期DLBCL患者的临床病理资料.结果 75例患者中接受单纯化疗20例,手术联合化疗55例;两组患者完全缓解率分别为65.0％(13/20)和83.6％(46/55),治疗有效率分别为75.0％(15/20)和92.7％ (51/55),5年生存率分别为86.9％和78.7％,差异均无统计学意义(均P＞0.05).单因素和多因素预后分析显示,国际预后指数(IPI)评分是DLBCL患者的独立预后因素(P＜0.05,HR=11.350,95％CI:1.011～127.371).结论 IPI评分是早期胃DLBCL中的独立预后因素;单纯化疗与手术联合化疗的疗效无显著差异.
목적 탐토조기원발성위미만대B세포림파류(DLBCL)적예후영향인소급치료방식적선택.방법 회고성분석천진의과대학부속종류의원1993년1월지2008년8월간경위경활검혹수술병리증실적75례조기DLBCL환자적림상병리자료.결과 75례환자중접수단순화료20례,수술연합화료55례;량조환자완전완해솔분별위65.0％(13/20)화83.6％(46/55),치료유효솔분별위75.0％(15/20)화92.7％ (51/55),5년생존솔분별위86.9％화78.7％,차이균무통계학의의(균P＞0.05).단인소화다인소예후분석현시,국제예후지수(IPI)평분시DLBCL환자적독립예후인소(P＜0.05,HR=11.350,95％CI:1.011～127.371).결론 IPI평분시조기위DLBCL중적독립예후인소;단순화료여수술연합화료적료효무현저차이.
Objective To explore the prognostic factors and to compare chemotherapy alone versus surgical resection plus chemotherapy for early stage primary gastric diffuse large B-cell lymphomas (DLBCL).Methods Clinical data of 75 patients who were diagnosed as primary gastric DLBCL between January 1993 and August 2008 in Cancer Institute and Hospital of Tianjin Medical University were reviewed retrospectively.Results Among these 75 patients,20 patients received chemotherapy alone and 55 underwent surgical resection plus chemotherapy.Complete remission rates were 65.0％(13/20) and 83.6％(46/55),effective rates were 75.0％(15/20) and 92.7％(51/55),and 5-year survival rates were 86.9％ and 78.7％ respectively in chemotherapy alone group and resection plus chemotherapy group,while the differences were not statistically significant (all P＞0.05).Multivariate Cox regression model showed that international prognosis index (IPI) was the only independent prognostic factor (P＜0.05,HR=11.350,95％CI:1.011-127.371).Conclusions In early stage of DLBCL,IPI is the only independent prognostic factor.The clinical outcomes are comparable between chemotherapy alone and surgical resection plus chemotherapy.