中华胃肠外科杂志
中華胃腸外科雜誌
중화위장외과잡지
CHINESE JOURNAL OF GASTROINTESTINAL SURGERY
2013年
3期
273-275
,共3页
杨映弘%颜璟%吴艳军%蔺原%岳晓林
楊映弘%顏璟%吳豔軍%藺原%嶽曉林
양영홍%안경%오염군%린원%악효림
2型糖尿病%袖状胃切除%回肠间置%脂质代谢
2型糖尿病%袖狀胃切除%迴腸間置%脂質代謝
2형당뇨병%수상위절제%회장간치%지질대사
Type 2 diabetes mellitus%Sleeve gastrectomy%Ileal interposition%Lipid Metabolism
目的 评价袖状胃切除间置回肠的十二指肠空肠旁路手术对非肥胖性2型糖尿病患者脂质代谢的影响.方法 回顾性分析2009年3月至2010年8月间在四川省攀枝花市中心医院接受袖状胃切除间置回肠的十二指肠空肠旁路手术的29例非肥胖型2型糖尿病患者的临床资料.术后12个月检测总胆固醇、三酰甘油、高密度脂蛋白、低密度脂蛋白、胰岛素抵抗指数及糖化血红蛋白(HbA1c)的变化.结果 术后12个月时,28例(96.5％)患者血糖得到控制,无需服降糖药,HbA1c从术前的(8.4±1.3)％降至术后的(6.2±0.8)％,另1例血糖亦获改善.25例(86.2％)患者脂质代谢紊乱得到纠正,其中19例术前高胆固醇血症患者中16例(84.2％)术后恢复正常,17例高三酰甘油血症患者中14例(82.3％)恢复正常,12例高密度脂蛋白异常患者中8例(66.6％)恢复正常,16例低密度脂蛋白异常的患者中5例(31.2％)恢复正常;总胆固醇/高密度脂蛋白从术前的5.6±1.2降至术后的2.8±1.0,三酰甘油/高密度脂蛋白从术前的3.2±1.3降至术后的1.5±0.8(均P＜0.01).结论 袖状胃切除间置回肠的十二指肠空肠旁路手术能有效地改善非肥胖型2型糖尿病患者的脂质代谢紊乱.
目的 評價袖狀胃切除間置迴腸的十二指腸空腸徬路手術對非肥胖性2型糖尿病患者脂質代謝的影響.方法 迴顧性分析2009年3月至2010年8月間在四川省攀枝花市中心醫院接受袖狀胃切除間置迴腸的十二指腸空腸徬路手術的29例非肥胖型2型糖尿病患者的臨床資料.術後12箇月檢測總膽固醇、三酰甘油、高密度脂蛋白、低密度脂蛋白、胰島素牴抗指數及糖化血紅蛋白(HbA1c)的變化.結果 術後12箇月時,28例(96.5％)患者血糖得到控製,無需服降糖藥,HbA1c從術前的(8.4±1.3)％降至術後的(6.2±0.8)％,另1例血糖亦穫改善.25例(86.2％)患者脂質代謝紊亂得到糾正,其中19例術前高膽固醇血癥患者中16例(84.2％)術後恢複正常,17例高三酰甘油血癥患者中14例(82.3％)恢複正常,12例高密度脂蛋白異常患者中8例(66.6％)恢複正常,16例低密度脂蛋白異常的患者中5例(31.2％)恢複正常;總膽固醇/高密度脂蛋白從術前的5.6±1.2降至術後的2.8±1.0,三酰甘油/高密度脂蛋白從術前的3.2±1.3降至術後的1.5±0.8(均P＜0.01).結論 袖狀胃切除間置迴腸的十二指腸空腸徬路手術能有效地改善非肥胖型2型糖尿病患者的脂質代謝紊亂.
목적 평개수상위절제간치회장적십이지장공장방로수술대비비반성2형당뇨병환자지질대사적영향.방법 회고성분석2009년3월지2010년8월간재사천성반지화시중심의원접수수상위절제간치회장적십이지장공장방로수술적29례비비반형2형당뇨병환자적림상자료.술후12개월검측총담고순、삼선감유、고밀도지단백、저밀도지단백、이도소저항지수급당화혈홍단백(HbA1c)적변화.결과 술후12개월시,28례(96.5％)환자혈당득도공제,무수복강당약,HbA1c종술전적(8.4±1.3)％강지술후적(6.2±0.8)％,령1례혈당역획개선.25례(86.2％)환자지질대사문란득도규정,기중19례술전고담고순혈증환자중16례(84.2％)술후회복정상,17례고삼선감유혈증환자중14례(82.3％)회복정상,12례고밀도지단백이상환자중8례(66.6％)회복정상,16례저밀도지단백이상적환자중5례(31.2％)회복정상;총담고순/고밀도지단백종술전적5.6±1.2강지술후적2.8±1.0,삼선감유/고밀도지단백종술전적3.2±1.3강지술후적1.5±0.8(균P＜0.01).결론 수상위절제간치회장적십이지장공장방로수술능유효지개선비비반형2형당뇨병환자적지질대사문란.
Objiective To evaluate the effect of sleeve gastrectomy with ileal interposition duodenojejunal bypass operation on lipid metabolism in non-obese type 2 diabetes mellitus patients.Methods Twenty-nine non-obese patients with type 2 diabetes mellitus underwent sleeve gastrectomy with ileal interposition duodenojejunal bypass operation.All the patients were subjected to the measurement of total cholesterol(TC),triglycerides (TG),high density lipoprotein (HDL),low density lipoprotein (LDL),homeostatic model assessment for insulin resistance (Homa-IR),glycosylated hemoglobin (HbAlc) at postoperative 12th month.Results Twelve months after ileal interposition duodenojejunal bypass operation,the blood glucose was controlled without taking hypoglycemic drugs in 28 patients (96.5％) and HbA1c decreased from (8.4±1.3)％ to (6.5±1.6)％(P＜0.01).Dyslipidemia were corrected in 25 cases (86.2％).TC became normal in 84.2％(15/19),and TG became normal in 82.3％(14/17).HDL became normal in 66.6％(8/12).LDL became normal in 31.2％(5/16).TC/HDL ratio decreased from 5.6±1.2 to 2.8±1.0(P＜0.01).TG/HDL ratio decreased from 3.2±1.3 to 1.5+0.8 (all P＜0.01).Conclusion Sleeve gastrectomy with ileal interposition duodenojejunal bypass is an effective operation for the correction of dyslipidemia in non-obese patients with type 2 diabetes mellitus.
