CAJ | 학술논문

局部晚期直肠癌标准的治疗方案为术前新辅助放化疗加手术的综合治疗.研究显示,直肠癌患者术前放化疗后达病理完全缓解者预后较好.尽管对这些患者的后续治疗方案有较大分歧,但已倾向于保守治疗而非根治性手术治疗.本文就局部晚期直肠癌术前新辅助放化疗后病理完全缓解的预后及预测等相关研究进展作一简要综述.
국부만기직장암표준적치료방안위술전신보조방화료가수술적종합치료.연구현시,직장암환자술전방화료후체병리완전완해자예후교호.진관대저사환자적후속치료방안유교대분기,단이경향우보수치료이비근치성수술치료.본문취국부만기직장암술전신보조방화료후병리완전완해적예후급예측등상관연구진전작일간요종술.
Neoadjuvant chemoradiotherapy followed by surgery is the standard treatment for patients with locally advanced rectal cancer.Controversy on whether patients should receive radical surgery after pathological complete response (pCR) after neoadjuvant chemoradiotherapy has remained since pCR patients have shown favorable long-term outcome.Progress in multidisciplinary modalities has been made,including MRI,PET/CT imaging studies,genetic expression profiling,etc.The methods of predicting pCR response are inspiring.In this article,we review the methods for prediction and prognostic effect of pCR response when patients with locally advanced rectal cancer are treated with neoadjuvant chemoradiotherapy.