CAJ | 학술논문

目的探讨结直肠癌组织中蛋白磷酸酶2A癌性抑制因子(CIP2A)的表达及其临床意义.方法采用免疫组织化学方法检测92例结直肠癌组织芯片中CIP2A的表达情况,分析其表达与患者临床病理因素及预后之间的关系.结果 CIP2A高表达与肿瘤TNM分期、组织分型、腹膜种植及肝转移有关(P＜0.05);但与患者性别、年龄、肿瘤部位、CEA、结直肠癌家族史及分化程度无关(P＞0.05).CIP2A高表达组1、3、5和10年总生存率分别为97.1％、71.4％、59.2％和44.4％,明显低于低表达组的98.2％、85.7％、80.3％和74.9％,两者差异具有统计学意义(P=0.021).多因素生存分析显示,CIP2A高表达并非是影响结直肠癌的独立不良预后因素(P=0.099,HR=1.982,95％CI:0.879～4.469).结论 CIP2A高表达与结直肠癌的临床病理特征密切相关,CIP2A可能成为潜在的结直肠癌转移和预后分子标志物或治疗靶点.
목적 탐토결직장암조직중단백린산매2A암성억제인자(CIP2A)적표체급기림상의의.방법 채용면역조직화학방법검측92례결직장암조직심편중CIP2A적표체정황,분석기표체여환자림상병리인소급예후지간적관계.결과 CIP2A고표체여종류TNM분기、조직분형、복막충식급간전이유관(P＜0.05);단여환자성별、년령、종류부위、CEA、결직장암가족사급분화정도무관(P＞0.05).CIP2A고표체조1、3、5화10년총생존솔분별위97.1％、71.4％、59.2％화44.4％,명현저우저표체조적98.2％、85.7％、80.3％화74.9％,량자차이구유통계학의의(P=0.021).다인소생존분석현시,CIP2A고표체병비시영향결직장암적독립불량예후인소(P=0.099,HR=1.982,95％CI:0.879～4.469).결론 CIP2A고표체여결직장암적림상병리특정밀절상관,CIP2A가능성위잠재적결직장암전이화예후분자표지물혹치료파점.
Objective To investigate the expression of cancerous inhibitor of protein phosphatase 2A(CIP2A) in human colorectal cancer,and to examine the association of CIP2A expression with clinicopathology and prognosis.Methods CIP2A expression in colorectal cancer tissue microarray of 92 cases was detected by immunohistochemistry method.Results Up-regulated CIP2A expression was closely related with TNM staging,histological type,peritoneal seeding and liver metastasis (all P＜0.05),but not related with gender,age,tumor location,CEA,family history and grade of differentiation.Overall survival rates of 1-,3-,5-,and 10-year in high CIP2A expression group were 97.1％,71.4％,59.2％,and 44.4％ respectively,significantly lower than 98.2％,85.7％,80.3％,and 74.9％ in low CIP2A expression group(P=0.021).Multivariate analysis showed that CIP2A was not an independent factor associated with prognosis (P=0.099,HR=1.982,95％CI:0.879 to 4.469).Conclusions Up-regulated CIP2A expression is closely related to clinicopathology of colorectal cancer.CIP2A may be used as a potential predictive marker of metastasis,prognosis and therapeutic target in colorectal cancer.