中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2009年
9期
789-791
,共3页
何磊英%刘娜%陆峥%张洁%潘桂花%唐文忠%王志阳%陈海莹%吴彦%诸索宇%蔡军%李樱
何磊英%劉娜%陸崢%張潔%潘桂花%唐文忠%王誌暘%陳海瑩%吳彥%諸索宇%蔡軍%李櫻
하뢰영%류나%륙쟁%장길%반계화%당문충%왕지양%진해형%오언%제색우%채군%리앵
精神分裂症%非典型抗精神病药%认知功能
精神分裂癥%非典型抗精神病藥%認知功能
정신분렬증%비전형항정신병약%인지공능
Schizophrenia%Atypical antipsychotic%Cognitive function
目的 比较单纯治疗与综合治疗对于稳定期精神分裂症认知功能的影响.方法 将137名稳定期精神分裂症患者分为单纯治疗组70例,综合治疗组67例.用威斯康星卡片分类测验(WCST)、连线测验(TMTA和TMTB)、中国修订韦氏记忆量表(WMS-RC)的视觉再生和中国修订韦氏成人智力量表(WAIS-RC)的数字符号、数字广度,评定稳定期精神分裂症患者基线和随访12月末的认知功能,比较治疗前后患者认知功能的变化.结果 单纯治疗组12月末WCST总正确数、完成分类数、总错误数均较基线显著改善(P<0.01～0.05),TMTA和TMTB完成任务时间和笔离开纸次数均低于基线(P<0.01),数字符号、数字广度、视觉再生成绩均显著优于基线(P<0.01);综合治疗组12月末数字符号、数字广度、视觉再生、TMTA完成任务时间和笔离开纸次数,以及WCST、TMTB的各项成绩均显著优于基线(P<0.01);综合治疗组12月末WCST各项成绩、TMTA完成任务时间(28.30±10.79)s、TMTA连接正确数(24.97±0.17)个、TMTA连接错误数(0.03±0.17)个、TMTB完成任务时间(56.19±27.15)s、TMTB笔离开纸次数(0.16±0.48)次、数字符号(65.58±7.91)分、数字广度(16.72±1.96)分及视觉再生(10.96±1.96)分成绩均优于单纯治疗组(P<0.01～0.05).结论 非典型抗精神病药对稳定期精神分裂症患者的认知功能有改善作用,综合治疗对于认知功能改善更明显.
目的 比較單純治療與綜閤治療對于穩定期精神分裂癥認知功能的影響.方法 將137名穩定期精神分裂癥患者分為單純治療組70例,綜閤治療組67例.用威斯康星卡片分類測驗(WCST)、連線測驗(TMTA和TMTB)、中國脩訂韋氏記憶量錶(WMS-RC)的視覺再生和中國脩訂韋氏成人智力量錶(WAIS-RC)的數字符號、數字廣度,評定穩定期精神分裂癥患者基線和隨訪12月末的認知功能,比較治療前後患者認知功能的變化.結果 單純治療組12月末WCST總正確數、完成分類數、總錯誤數均較基線顯著改善(P<0.01～0.05),TMTA和TMTB完成任務時間和筆離開紙次數均低于基線(P<0.01),數字符號、數字廣度、視覺再生成績均顯著優于基線(P<0.01);綜閤治療組12月末數字符號、數字廣度、視覺再生、TMTA完成任務時間和筆離開紙次數,以及WCST、TMTB的各項成績均顯著優于基線(P<0.01);綜閤治療組12月末WCST各項成績、TMTA完成任務時間(28.30±10.79)s、TMTA連接正確數(24.97±0.17)箇、TMTA連接錯誤數(0.03±0.17)箇、TMTB完成任務時間(56.19±27.15)s、TMTB筆離開紙次數(0.16±0.48)次、數字符號(65.58±7.91)分、數字廣度(16.72±1.96)分及視覺再生(10.96±1.96)分成績均優于單純治療組(P<0.01～0.05).結論 非典型抗精神病藥對穩定期精神分裂癥患者的認知功能有改善作用,綜閤治療對于認知功能改善更明顯.
목적 비교단순치료여종합치료대우은정기정신분렬증인지공능적영향.방법 장137명은정기정신분렬증환자분위단순치료조70례,종합치료조67례.용위사강성잡편분류측험(WCST)、련선측험(TMTA화TMTB)、중국수정위씨기억량표(WMS-RC)적시각재생화중국수정위씨성인지역량표(WAIS-RC)적수자부호、수자엄도,평정은정기정신분렬증환자기선화수방12월말적인지공능,비교치료전후환자인지공능적변화.결과 단순치료조12월말WCST총정학수、완성분류수、총착오수균교기선현저개선(P<0.01～0.05),TMTA화TMTB완성임무시간화필리개지차수균저우기선(P<0.01),수자부호、수자엄도、시각재생성적균현저우우기선(P<0.01);종합치료조12월말수자부호、수자엄도、시각재생、TMTA완성임무시간화필리개지차수,이급WCST、TMTB적각항성적균현저우우기선(P<0.01);종합치료조12월말WCST각항성적、TMTA완성임무시간(28.30±10.79)s、TMTA련접정학수(24.97±0.17)개、TMTA련접착오수(0.03±0.17)개、TMTB완성임무시간(56.19±27.15)s、TMTB필리개지차수(0.16±0.48)차、수자부호(65.58±7.91)분、수자엄도(16.72±1.96)분급시각재생(10.96±1.96)분성적균우우단순치료조(P<0.01～0.05).결론 비전형항정신병약대은정기정신분렬증환자적인지공능유개선작용,종합치료대우인지공능개선경명현.
Objective To compare the effect of simple antipsychotics therapy and integrated treatment on cognitive function of stable schizophrenia patients.Methods 137 stable schizophrenia patients were divided into two groups,70 patients in control group which using atypical antipsychotics only(n=70)and integrated treatment group which atypical antipsychotics combined with bio-psycho-social intervention(n=67).Using Wisconsion Card Sorting Test(WCST),Trail Making Test(TMTA and TMTB),Digit Symbol and Digit Span in Wechsler Adult Intelligence Scale Revised in China(WAIS-RC),Visual Reproduction in Wechsler Memory Scale-Revised in China (WMS-RC)to evaluate cognitive function of the Stable schizophrenia patients at the baseline and 12 months later.Results After 12 months,the results of control group such as total correct number of WCST,sorting of WCST,digit symbol and total wrong number of WCST were better than baseline(P＜0.01～0.05),the score of digit span and visual reproduction were higher than baseline.and the time finished TMTA and TMTB were less than baseline(P＜0.01).After 12 months,the results of integrated treatment group such as digit symbol,digit span and visual reproduction,WCST and TMT were better than baseline(P＜0.01).After 12 months,the results of integrated treatment group such as digit symbol(65.58±7.91),digit span(16.72±1.96)and visual reproduction(10.96±1.96),WCST,TMTA and TMTB were better than control group(P＜0.01～0.05).Conclusion Integrated treatment were better on the cognitive function of stable schizophrenia patients than simple atypical antipsychotica treatment.
