中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2012年
11期
991-993
,共3页
游聪%邓红珠%岑超群%唐春%李建英%邹小兵
遊聰%鄧紅珠%岑超群%唐春%李建英%鄒小兵
유총%산홍주%잠초군%당춘%리건영%추소병
孤独症%性激素%孕酮
孤獨癥%性激素%孕酮
고독증%성격소%잉동
Autism%Sex steroids%Progesterone
目的 探讨青春前期孤独症患儿与正常儿童性激素水平差异,以及其可能的临床意义.方法 应用直接化学发光法检测44例孤独症患儿[男35例/女9例,平均年龄(47.5 ±18.9)月]和44例正常对照儿童[男35例/女9例,平均年龄(45.0±18.7)月]的血清卵泡刺激素(Follicle-stimulating hormone,FSH)、黄体生成素(Luteotropic hormone,LH)、睾酮(Testosterone,T)、雌二醇(Estradiol,E2)、孕酮(Progesterone,P)、硫酸脱氢表雄酮(Dehydroepiandrosterone sulfate,DHEA-S)和雄烯二酮(Androstenedione,A)水平,并进行统计分析.结果 ①孤独症组儿童血清孕酮水平(＜0.48,2.08) nmol/L低于正常对照组儿童(＜0.48,6.95) nmol/L,差异具有统计学意义(Z =3.564,P＜0.01),而FSH、LH、T、E2、DHEA-S、A激素水平两组之间差异均无统计学意义(Z分别为0.831,1.167,1.091,0.906,0.830,0.826,均P＞0.05)；②＜48月和≥48月孤独症组患儿血清孕酮水平无统计学差异(Z=0.150,P=0.881)；男性和女性孤独症组患儿血清孕酮水平亦差异无统计学意义(Z=1.972,P=0.249).结论 孤独症患儿孕酮水平降低,且与性别、年龄无关,提示其水平变化与孤独症的发生密切相关.
目的 探討青春前期孤獨癥患兒與正常兒童性激素水平差異,以及其可能的臨床意義.方法 應用直接化學髮光法檢測44例孤獨癥患兒[男35例/女9例,平均年齡(47.5 ±18.9)月]和44例正常對照兒童[男35例/女9例,平均年齡(45.0±18.7)月]的血清卵泡刺激素(Follicle-stimulating hormone,FSH)、黃體生成素(Luteotropic hormone,LH)、睪酮(Testosterone,T)、雌二醇(Estradiol,E2)、孕酮(Progesterone,P)、硫痠脫氫錶雄酮(Dehydroepiandrosterone sulfate,DHEA-S)和雄烯二酮(Androstenedione,A)水平,併進行統計分析.結果 ①孤獨癥組兒童血清孕酮水平(＜0.48,2.08) nmol/L低于正常對照組兒童(＜0.48,6.95) nmol/L,差異具有統計學意義(Z =3.564,P＜0.01),而FSH、LH、T、E2、DHEA-S、A激素水平兩組之間差異均無統計學意義(Z分彆為0.831,1.167,1.091,0.906,0.830,0.826,均P＞0.05)；②＜48月和≥48月孤獨癥組患兒血清孕酮水平無統計學差異(Z=0.150,P=0.881)；男性和女性孤獨癥組患兒血清孕酮水平亦差異無統計學意義(Z=1.972,P=0.249).結論 孤獨癥患兒孕酮水平降低,且與性彆、年齡無關,提示其水平變化與孤獨癥的髮生密切相關.
목적 탐토청춘전기고독증환인여정상인동성격소수평차이,이급기가능적림상의의.방법 응용직접화학발광법검측44례고독증환인[남35례/녀9례,평균년령(47.5 ±18.9)월]화44례정상대조인동[남35례/녀9례,평균년령(45.0±18.7)월]적혈청란포자격소(Follicle-stimulating hormone,FSH)、황체생성소(Luteotropic hormone,LH)、고동(Testosterone,T)、자이순(Estradiol,E2)、잉동(Progesterone,P)、류산탈경표웅동(Dehydroepiandrosterone sulfate,DHEA-S)화웅희이동(Androstenedione,A)수평,병진행통계분석.결과 ①고독증조인동혈청잉동수평(＜0.48,2.08) nmol/L저우정상대조조인동(＜0.48,6.95) nmol/L,차이구유통계학의의(Z =3.564,P＜0.01),이FSH、LH、T、E2、DHEA-S、A격소수평량조지간차이균무통계학의의(Z분별위0.831,1.167,1.091,0.906,0.830,0.826,균P＞0.05)；②＜48월화≥48월고독증조환인혈청잉동수평무통계학차이(Z=0.150,P=0.881)；남성화녀성고독증조환인혈청잉동수평역차이무통계학의의(Z=1.972,P=0.249).결론 고독증환인잉동수평강저,차여성별、년령무관,제시기수평변화여고독증적발생밀절상관.
Objective To investigate the changes of the serum sex steroids levels in prepuberal children with autism,and analyze the possible clinical implications.Methods The serum sex steroids,including folliclestimulating hormone(FSH),luteotropic hormone(LH),testosterone(T),estradiol(E2),progesterone(P),dehydroepiandrosterone sulfate(DHEA-S) and androstenedione were measured in 44 autistic children(35 boys and 9girls,47.5 ± 18.9 months) and 44 normal children(35 boys and 9 girls,45.0 ± 18.7 months),using chemiluminescence immunoassay.Results ①The progesterone levels in autism group were significantly lower than control group((＜ 0.48,2.08) nmoL/L vs (＜ 0.48,6.95) nmol/L,Z =-3.564,P ＜ 0.01),but no statistical differences were observed in other sex steroids levels(P＞ 0.05).②The progesterone levels in ＜ 48 months autism group showed no significant differences from ≥48 months autism group (Z =0.150,P ＞ 0.05).There were no statistical differences in progesterone level between the boys and girls of the autism group(Z=1.972,P＞0.05).Conclusion The progesterone levels are lower in autistic children,and they are not associated with the children's age or gender.This study indicates that the progesterone levels are closely associated with autism.
