CAJ | 학술논문

目的探讨轻度认知损害(MCI)、轻度及中度阿尔茨海默病(AD)患者左右侧别海马头体尾各区磁共振T2信号强度的改变.方法收集MCI、轻度及中度AD患者和老年健康志愿者各15例,所有受试者均行FSE-T2序列,并在工作站手工勾绘海马头体尾各区感兴趣区,测量其磁共振T2信号强度.并分析各部磁共振T2信号强度与简易智力状态检查(MMSE)评分的相关性.结果 MCI患者的左侧海马头部(569.80±15.74)、轻度AD双侧海马头部(左:573.75±16.16;右:570.21±15.43)及中度AD双侧海马头部(左:592.31±15.77；右:582.35±16.80)、左侧海马尾部(578.36±16.08)磁共振T2信号强度较对照组均差异有统计学意义(P＜0.05).同时轻度AD患者的左侧海马尾部的信号存在增高趋势.MMSE评分与MCI、轻、中度AD组的双侧海马部分亚区呈负相关.结论 MCI、轻中度AD患者双侧海马部分亚区的磁共振T2信号强度存在异常,而对左侧海马头部的早期定量测量,将有助于对AD的早期诊断.
목적 탐토경도인지손해(MCI)、경도급중도아이자해묵병(AD)환자좌우측별해마두체미각구자공진T2신호강도적개변.방법 수집MCI、경도급중도AD환자화노년건강지원자각15례,소유수시자균행FSE-T2서렬,병재공작참수공구회해마두체미각구감흥취구,측량기자공진T2신호강도.병분석각부자공진T2신호강도여간역지력상태검사(MMSE)평분적상관성.결과 MCI환자적좌측해마두부(569.80±15.74)、경도AD쌍측해마두부(좌:573.75±16.16;우:570.21±15.43)급중도AD쌍측해마두부(좌:592.31±15.77；우:582.35±16.80)、좌측해마미부(578.36±16.08)자공진T2신호강도교대조조균차이유통계학의의(P＜0.05).동시경도AD환자적좌측해마미부적신호존재증고추세.MMSE평분여MCI、경、중도AD조적쌍측해마부분아구정부상관.결론 MCI、경중도AD환자쌍측해마부분아구적자공진T2신호강도존재이상,이대좌측해마두부적조기정량측량,장유조우대AD적조기진단.
Objective To investigate the change of the hippocampal MRI T2 signal intensity in mild cognitive impairment(MCI) and mild and moderate Alzheimer's disease,and to give imageological help to the early diagnosis and treatment of Alzheimer's disease(AD).Methods 15 patients with MCI,15 patients with mild AD,15patients with moderate AD and 15 age-and gender-matched healthy people were scanned by MRI using FSE-T2sequence,and the margin of hippocampal subfields was outlined manually for each side to measure the T2 signal intensity.The relationship between hippocampal T2 signal intensity and the scores of MMSE was analyzed.Results There was significant difference of the T2 signal intensity in the left hippocampal head of MCI,the bilateral hippocampal head of mild AD and the bilateral hippocampal head,the left hippocampal tail of moderate AD (P ＜0.05),while the numerical value of the left head of mild AD was bigger than the control group (but P ＞ 0.05).There was inverse correlation between some hippocampal subfields T2 signal intensity and the scores of MMSE.Conclusion There is abnormality of some hippocampal subfields T2 signal intensity,and the quantitative measurement early of the left hippocampal head is useful in making clinical diagnosis of AD in its early stage.