CAJ | 학술논문

目的观察西酞普兰治疗脑梗死后病理性哭泣的疗效.方法脑梗死后病理性哭泣106例,以投币法随机分为两组,西酞普兰治疗组54例,对照组52例,对照组给予常规脑血管病治疗,治疗组在此基础上加用西酞普兰10 ～ 20mg,1次/日,连服3月,比较两组治疗后总有效率、起效时间和长谷川痴呆量表积分.结果治疗组和对照组总有效率分别是94.4％和38.5％；起效时间分别是(1.98±1.24)d和(78.00±17.95)d；痴呆量表积分分别是(8.43±2.21)分和(6.24±2.02)分,两组的差异均有统计学意义(P＜0.01).结论西酞普兰治疗病理性哭泣效果好,起效快,不但能有效控制哭泣发作,而且能显著提高患者的认知功能.
목적 관찰서태보란치료뇌경사후병이성곡읍적료효.방법 뇌경사후병이성곡읍106례,이투폐법수궤분위량조,서태보란치료조54례,대조조52례,대조조급여상규뇌혈관병치료,치료조재차기출상가용서태보란10 ～ 20mg,1차/일,련복3월,비교량조치료후총유효솔、기효시간화장곡천치태량표적분.결과 치료조화대조조총유효솔분별시94.4％화38.5％；기효시간분별시(1.98±1.24)d화(78.00±17.95)d；치태량표적분분별시(8.43±2.21)분화(6.24±2.02)분,량조적차이균유통계학의의(P＜0.01).결론 서태보란치료병이성곡읍효과호,기효쾌,불단능유효공제곡읍발작,이차능현저제고환자적인지공능.
Objective To investigate efficacy of citalopram on pathological crying after cerebral infarction.Methods 106 patients with pathological crying after cerebral infarction were randomly divided into two groups,treatment group(54 cases) and control group(52 cases).Control group received conventional treatment of cerebrovascular disease.Treatment group taken citalopraml0-20mg orally one time per day for three months based on conventional treatment.The total response rate,effectual time,and Hasegawa Dementia Scale (HDS) scores were compared between two groups after treatment.Results There were significant differences in total response rates (94.4％ and 38.5％,respectively),effectual time(1.98 ± 1.24 and 78 ± 17.95,respectively) and HDS(8.43 ±2.21 and 6.24 ±2.02,respectively) between treatment group and control group (P ＜ 0.01).Conclusion The study suggests that it is effective to treat pathological crying with citalopram and its effect is quick.Citalopram can not only control patient’s pathological crying,but also improve cognitive function.