CAJ | 학술논문

目的探讨艾滋病病毒感染者(HIV±)和艾滋病患者(AIDS)的神经认知功能变化,了解艾滋病病毒感染者和艾滋病患者中各神经心理测试条目的异常发生数和比例,并分析神经心理测试结果与HAND临床诊断结果的相关性.方法运用全套神经心理测验对通过多阶段分层随机抽取到的230例HIV ±/AIDS住院病人和99例HIV阴性者进行神经认知功能研究.结果 HIV/AIDS患者中12项神经心理测试条目异常发生比例不等,位于21.3％～58.7％之间.12项神经心理测评结果都与HAND临床诊断结果存在相关关系,其中SC时间、SCW时间、颜色连线和WSCT持续错误数4个条目测评结果与临床诊断结果成正相关,相关系数分别为0.384,0.335,0.237和0.129.其余测试项目的测评结果与临床诊断结果成负相关,相关系数最高的是词汇流畅性,最低的是WSCT持续错误数.结论 HIV/AIDS患者中12项神经心理测试条目的异常发生比例较高,且均影响着受试者有无HIV相关性神经认知障碍的评定.提示全套神经心理测验可较好的用于HIV/AIDS患者神经认知功能的初步研究.
목적 탐토애자병병독감염자(HIV±)화애자병환자(AIDS)적신경인지공능변화,료해애자병병독감염자화애자병환자중각신경심리측시조목적이상발생수화비례,병분석신경심리측시결과여HAND림상진단결과적상관성.방법 운용전투신경심리측험대통과다계단분층수궤추취도적230례HIV ±/AIDS주원병인화99례HIV음성자진행신경인지공능연구.결과 HIV/AIDS환자중12항신경심리측시조목이상발생비례불등,위우21.3％～58.7％지간.12항신경심리측평결과도여HAND림상진단결과존재상관관계,기중SC시간、SCW시간、안색련선화WSCT지속착오수4개조목측평결과여림상진단결과성정상관,상관계수분별위0.384,0.335,0.237화0.129.기여측시항목적측평결과여림상진단결과성부상관,상관계수최고적시사회류창성,최저적시WSCT지속착오수.결론 HIV/AIDS환자중12항신경심리측시조목적이상발생비례교고,차균영향착수시자유무HIV상관성신경인지장애적평정.제시전투신경심리측험가교호적용우HIV/AIDS환자신경인지공능적초보연구.
Objective To examine cognitive function of the HIV/AIDS patients in the hospitals measured by the neuropsychological tests battery,make an evaluation of cognitive function of the HIV/AIDS patients,and diagnose the patients with HIV-associated neurocognitive disorders(HAND).Methods Ninety-nine normal individuals and two hundred and thirty HIV/AIDS inpatients,who were sampled by multi-stage random stratified in Guangxi,were tested by the 12 items of the neuropsychological tests.Results HIV / AIDS patients with abnormal neuropsychological test entries proportion ranges located between 21.3％-58.7 ％.The results of 12 items of the neuropsychological tests were associated with the results of clinical diagnosis.Among them,the results of SC time,SCW time,color attachment,and numbers of the contiguous error in WSCT tests were positively associated with the results of clinical diagnosis,and the correlation coefficient were 0.384,0.335,0.237 and 0.129,respectively.There was a negative correlation between the results of the rest assessment and the results of clinical diagnosis ; vocabulary fluency was the highest correlation coefficient,while numbers of the contiguous error in WSCT tests was the lowest.Conclusion A higher proportion of abnormal occurrence of Guangxi HIV / AIDS patients in the 12 neuropsychological test entry,and affect the subjects with or without HIV-related neurological assessment of cognitive impairment.The data suggest that a full neuropsychological tests can be better used for the preliminary study of the HIV ±/AIDS patients neurocognitive function.