中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2013年
4期
308-310
,共3页
陈新贵%李晶晶%朱春燕%余凤琼%邱琳琳%张敬杰%汪凯
陳新貴%李晶晶%硃春燕%餘鳳瓊%邱琳琳%張敬傑%汪凱
진신귀%리정정%주춘연%여봉경%구림림%장경걸%왕개
乳腺癌%化疗%认知损害%神经心理学测验
乳腺癌%化療%認知損害%神經心理學測驗
유선암%화료%인지손해%신경심이학측험
Breast cancer%Chemotherapy%Cognitive impairment%Neuropsychological tests
目的 探讨乳腺癌患者化疗后认知功能损害神经心理学特征.方法 采用成套神经心理学量表对38例化疗组乳腺癌患者(CT)、38例非化疗组乳腺癌患者(non-CT)及40例健康对照组(HC)被试进行评定,比较各组被试神经心理学特征.结果 CT组、non-CT组及HC组在倒背测验得分分别为(4.42±1.11)分、(5.18±1.16)分、(5.13±1.22)分,在延迟记忆测验分别为(8.55±1.75)分、(9.58±1.50)分、(10.13±1.92)分,在再认回忆测验分别为(7.68±1.90)分、(8.97±1.62)分、(9.08±2.09)分,并且CT组的得分均低于non-CT组和HC组,差异有统计学意义(均P＜0.01)；CT组、non-CT组及HC组在Stroop 任务B中完成时间分别为(21.54±5.02)s、(19.37±4.26)s、(18.82±3.05)s,在Stroop任务C中分别为(34.85±8.46)s、(31.02±7.38)s、(30.61±7.83)s,在连线任务(TMT)任务B中分别为(102.79±11.90)s、(96.22±12.07)s、(97.21±11.64)s,CT组在上述的三项测验完成时间上均长于non-CT组和HC组,差异有统计学意义(均P＜0.05)；各组被试的顺背、即刻记忆、Stroop任务A、TMT任务A和VFT评分差异无统计学意义(均P＞0.05).结论 推测乳腺癌患者化疗后存在认知功能损害,主要表现在记忆、注意能力和执行功能不同程度的改变.
目的 探討乳腺癌患者化療後認知功能損害神經心理學特徵.方法 採用成套神經心理學量錶對38例化療組乳腺癌患者(CT)、38例非化療組乳腺癌患者(non-CT)及40例健康對照組(HC)被試進行評定,比較各組被試神經心理學特徵.結果 CT組、non-CT組及HC組在倒揹測驗得分分彆為(4.42±1.11)分、(5.18±1.16)分、(5.13±1.22)分,在延遲記憶測驗分彆為(8.55±1.75)分、(9.58±1.50)分、(10.13±1.92)分,在再認迴憶測驗分彆為(7.68±1.90)分、(8.97±1.62)分、(9.08±2.09)分,併且CT組的得分均低于non-CT組和HC組,差異有統計學意義(均P＜0.01)；CT組、non-CT組及HC組在Stroop 任務B中完成時間分彆為(21.54±5.02)s、(19.37±4.26)s、(18.82±3.05)s,在Stroop任務C中分彆為(34.85±8.46)s、(31.02±7.38)s、(30.61±7.83)s,在連線任務(TMT)任務B中分彆為(102.79±11.90)s、(96.22±12.07)s、(97.21±11.64)s,CT組在上述的三項測驗完成時間上均長于non-CT組和HC組,差異有統計學意義(均P＜0.05)；各組被試的順揹、即刻記憶、Stroop任務A、TMT任務A和VFT評分差異無統計學意義(均P＞0.05).結論 推測乳腺癌患者化療後存在認知功能損害,主要錶現在記憶、註意能力和執行功能不同程度的改變.
목적 탐토유선암환자화료후인지공능손해신경심이학특정.방법 채용성투신경심이학량표대38례화료조유선암환자(CT)、38례비화료조유선암환자(non-CT)급40례건강대조조(HC)피시진행평정,비교각조피시신경심이학특정.결과 CT조、non-CT조급HC조재도배측험득분분별위(4.42±1.11)분、(5.18±1.16)분、(5.13±1.22)분,재연지기억측험분별위(8.55±1.75)분、(9.58±1.50)분、(10.13±1.92)분,재재인회억측험분별위(7.68±1.90)분、(8.97±1.62)분、(9.08±2.09)분,병차CT조적득분균저우non-CT조화HC조,차이유통계학의의(균P＜0.01)；CT조、non-CT조급HC조재Stroop 임무B중완성시간분별위(21.54±5.02)s、(19.37±4.26)s、(18.82±3.05)s,재Stroop임무C중분별위(34.85±8.46)s、(31.02±7.38)s、(30.61±7.83)s,재련선임무(TMT)임무B중분별위(102.79±11.90)s、(96.22±12.07)s、(97.21±11.64)s,CT조재상술적삼항측험완성시간상균장우non-CT조화HC조,차이유통계학의의(균P＜0.05)；각조피시적순배、즉각기억、Stroop임무A、TMT임무A화VFT평분차이무통계학의의(균P＞0.05).결론 추측유선암환자화료후존재인지공능손해,주요표현재기억、주의능력화집행공능불동정도적개변.
Objective To explore the neuropsychological features of cognitive impairment induced by chemotherapy for breast cancer patients.Methods A neuropsychology battery was applied in this study.Seventy six breast cancer patients were enrolled in the test and classified as chemotherapy treatment patients(CT,n =38),and non-chemotherapy treatment patients(non-CT,n =38).Forty normal female people were also evaluated as healthy control(HC).Results Compared with HC and non-CT groups,the correct number of backward(CT:4.42±1.11,non-CT:5.18 ± 1.16,HC:5.13 ± 1.22),delayed recall (CT:8.55 ± 1.75,non-CT:9.58 ± 1.50,HC:10.13 ± 1.92) and recognition (CT:7.68 ± 1.90,non-CT:8.97 ± 1.62,HC:9.08 ± 2.09) were low in the CT group (P ＜ 0.01).The reaction time of Stroop test B (CT:(21.54 ± 5.02) s,non-CT:(19.37 ± 4.26) s,HC:(18.82 ± 3.05) s),Stroop test C (CT:(34.85 ± 8.46) s,non-CT:(31.02 ± 7.38) s,HC:(30.61 ± 7.83) s) and TMT test B(CT:(102.79± 11.90)s,non-CT:(96.22 ± 12.07) s,HC:(97.21 ± 11.64)s) were long in the CT group (P ＜ 0.05).There were no significant differences in the Forward,Immediate Recall,Stroop test A,TMT test A and VFT among three groups(P＞ 0.05).Conclusion Breast cancer patients with chemotherapy treatment have cognitive impairment in the domains of memory,attention and executive functions.
