CAJ | 학술논문

目的通过对阿尔茨海默病(Alzheimer's disease,AD)患者的观念运用和及物运用功能的研究,初步了解AD患者的运用能力及运用功能障碍的类型和机制.方法采用功能匹配(包括对图片物体命名及功能相关选择)、及物使用工具、新工具任务和图片命名任务,对20例AD患者以及20例对照组的运用功能进行对照研究.结果 AD患者的运用功能明显下降,与对照组相比,物体命名、功能匹配、及物使用工具、新工具任务和有生命图片及无生命图片命名测试差异均有统计学意义(分别为t=-6.45,-5.94,-4.16,-4.81,-2.17,-2.08；均P＜0.05).相关分析提示AD患者的AD评定量表-认知部分(ADAS-cog)、简明精神状态检查(MMSE)、日常生活能力量表(ADL)评分与运用功能有显著性相关(P＜0.05).结论 AD患者在各项运用功能中均有损害,主要表现在观念运动性和观念性失用,其中以概念损害更严重,推测AD患者的失用可能是由于语义加工的障碍所致.
목적 통과대아이자해묵병(Alzheimer's disease,AD)환자적관념운용화급물운용공능적연구,초보료해AD환자적운용능력급운용공능장애적류형화궤제.방법 채용공능필배(포괄대도편물체명명급공능상관선택)、급물사용공구、신공구임무화도편명명임무,대20례AD환자이급20례대조조적운용공능진행대조연구.결과 AD환자적운용공능명현하강,여대조조상비,물체명명、공능필배、급물사용공구、신공구임무화유생명도편급무생명도편명명측시차이균유통계학의의(분별위t=-6.45,-5.94,-4.16,-4.81,-2.17,-2.08；균P＜0.05).상관분석제시AD환자적AD평정량표-인지부분(ADAS-cog)、간명정신상태검사(MMSE)、일상생활능역량표(ADL)평분여운용공능유현저성상관(P＜0.05).결론 AD환자재각항운용공능중균유손해,주요표현재관념운동성화관념성실용,기중이개념손해경엄중,추측AD환자적실용가능시유우어의가공적장애소치.
Objective To understand the capacity of application,and discuss the types as well as the mechanism of these dysfunctions.Methods A battery of neuropsychological tests including tool naming,tool naming by function,using of transitive tools,novel task test and naming photographs (living and inanimate) were applied in this study.20 AD patients and 20 healthy controls were enrolled in the study.Results The AD patients performed worse than the controls on the tool naming,tool naming by function,application of transitive tool,novel task test,naming tasks of living and inanimate pictures.The results represented significance in all of the tests (t =-6.54,-5.94,-4.16,-4.81,-2.17,-2.08 ; P ＜ 0.05).There were significant correlations between the performances in application the tasks and the ADAS-cog,MMSE and ADL scores (P ＜ 0.05).Conclusion The findings indicate that AD patients have apraxia,mainly impairment in ideomotor apraxia and ideational apraxia.Additionally,the patients have significantly decreased performance in ideational apraxia.The result suggests that AD patients' apraxia might result from the semantic processing disorder.