中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2013年
11期
989-991
,共3页
梁振江%陈旭红%滕以书%韩赛红
樑振江%陳旭紅%滕以書%韓賽紅
량진강%진욱홍%등이서%한새홍
睡眠呼吸暂停综合征%食欲素A%感觉统合能力
睡眠呼吸暫停綜閤徵%食欲素A%感覺統閤能力
수면호흡잠정종합정%식욕소A%감각통합능력
Obstructive sleep apnea-hypopnea syndrome%Orexin-A%Sensory integration capacity
目的 探讨睡眠呼吸暂停综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)儿童手术治疗前后血浆食欲素A (Orexin-A)水平变化及与感觉统合能力的关系.方法 接受扁桃体切除和/或腺样体刮除术的儿童OSAHS患者120例,正常对照组30例.并按呼吸暂停低通气指数(apnea hypopnea index,AHI)将OSAHS组分为轻度组(5次/h≤AHI＜20次/h,n=13);中度组(20次/h≤AHI＜40次/h,n=76);重度组(AHI≥40次/h,n=31).同时按感觉统合能力评分还将OSAHS组分为正常组30名、轻度失调组47名、中度失调组28名、重度失调组15名.术前及术后6个月进行血浆Orexin-A水平测定及儿童感觉统合能力评定.结果 OSAHS组患儿血浆Orexin-A浓度[(0.41±0.06)μg/ml]高于正常对照组[(0.31±0.04) μg/ml],差异有统计学意义(P＜0.01);不同严重程度OSAHS患儿手术前后血浆Orexin-A浓度比较,轻度组[术前(0.33±0.02)μg/ml,术后(0.28±0.03) μg/ml]、中度组[术前(0.39±0.04) μg/ml,术后(0.29±0.03) μg/ml]、重度组[术前(0.49±0.04) μg/ml,术后(0.32±0.02) μg/ml]差异均有统计学意义(P＜0.01).AHI指数与术前血浆Orexin-A浓度显著相关(r=0.803,P＜0.01).感觉统合测评分值与术前血浆Orexin-A浓度也存在显著相关(r=-0.812,P＜0.01).结论 血浆Orexin-A浓度与儿童OSAHS严重程度及其行为认知能力改变关系密切,可能成为儿童OSAHS诊断和预后的血浆标志物.
目的 探討睡眠呼吸暫停綜閤徵(obstructive sleep apnea-hypopnea syndrome,OSAHS)兒童手術治療前後血漿食欲素A (Orexin-A)水平變化及與感覺統閤能力的關繫.方法 接受扁桃體切除和/或腺樣體颳除術的兒童OSAHS患者120例,正常對照組30例.併按呼吸暫停低通氣指數(apnea hypopnea index,AHI)將OSAHS組分為輕度組(5次/h≤AHI＜20次/h,n=13);中度組(20次/h≤AHI＜40次/h,n=76);重度組(AHI≥40次/h,n=31).同時按感覺統閤能力評分還將OSAHS組分為正常組30名、輕度失調組47名、中度失調組28名、重度失調組15名.術前及術後6箇月進行血漿Orexin-A水平測定及兒童感覺統閤能力評定.結果 OSAHS組患兒血漿Orexin-A濃度[(0.41±0.06)μg/ml]高于正常對照組[(0.31±0.04) μg/ml],差異有統計學意義(P＜0.01);不同嚴重程度OSAHS患兒手術前後血漿Orexin-A濃度比較,輕度組[術前(0.33±0.02)μg/ml,術後(0.28±0.03) μg/ml]、中度組[術前(0.39±0.04) μg/ml,術後(0.29±0.03) μg/ml]、重度組[術前(0.49±0.04) μg/ml,術後(0.32±0.02) μg/ml]差異均有統計學意義(P＜0.01).AHI指數與術前血漿Orexin-A濃度顯著相關(r=0.803,P＜0.01).感覺統閤測評分值與術前血漿Orexin-A濃度也存在顯著相關(r=-0.812,P＜0.01).結論 血漿Orexin-A濃度與兒童OSAHS嚴重程度及其行為認知能力改變關繫密切,可能成為兒童OSAHS診斷和預後的血漿標誌物.
목적 탐토수면호흡잠정종합정(obstructive sleep apnea-hypopnea syndrome,OSAHS)인동수술치료전후혈장식욕소A (Orexin-A)수평변화급여감각통합능력적관계.방법 접수편도체절제화/혹선양체괄제술적인동OSAHS환자120례,정상대조조30례.병안호흡잠정저통기지수(apnea hypopnea index,AHI)장OSAHS조분위경도조(5차/h≤AHI＜20차/h,n=13);중도조(20차/h≤AHI＜40차/h,n=76);중도조(AHI≥40차/h,n=31).동시안감각통합능력평분환장OSAHS조분위정상조30명、경도실조조47명、중도실조조28명、중도실조조15명.술전급술후6개월진행혈장Orexin-A수평측정급인동감각통합능력평정.결과 OSAHS조환인혈장Orexin-A농도[(0.41±0.06)μg/ml]고우정상대조조[(0.31±0.04) μg/ml],차이유통계학의의(P＜0.01);불동엄중정도OSAHS환인수술전후혈장Orexin-A농도비교,경도조[술전(0.33±0.02)μg/ml,술후(0.28±0.03) μg/ml]、중도조[술전(0.39±0.04) μg/ml,술후(0.29±0.03) μg/ml]、중도조[술전(0.49±0.04) μg/ml,술후(0.32±0.02) μg/ml]차이균유통계학의의(P＜0.01).AHI지수여술전혈장Orexin-A농도현저상관(r=0.803,P＜0.01).감각통합측평분치여술전혈장Orexin-A농도야존재현저상관(r=-0.812,P＜0.01).결론 혈장Orexin-A농도여인동OSAHS엄중정도급기행위인지능력개변관계밀절,가능성위인동OSAHS진단화예후적혈장표지물.
Objective To explore the changes of plasma orexin-A level before and after operation in obstructive sleep apnea-hypopnea syndrome(OSAHS) children and its effect on their behavior performance.Methods 120 cases OSAHS children performed tonsillectomy and / or adenoidectomy and 30 cases normal children as control group.According to the AHI index,the OSAHS group was divided into mild group (5 times/h ≤ AHI ＜ 20times/h,n=13),moderate group (20/h ≤ AHI ＜40/h,n=76),and severe group (AHI ≥ 40 times / h,n=31).And at the same time,according to the sensory integration ratings,OSAHS group was divided into normal group(n =30),mildly abnormal group (n =47),moderately abnormal group (n =28),severely abnormal group (n =15).Before operation and 6 months after operation,plasma orexin-A levels and children's sensory integration were measured.Results Plasma orexin-A level of the OSAHS group ((0.41 ± 0.06) μg/ml) was significantly higher compared with the control group((0.31±0.04) μg/ml) (P＜0.01).In orexin-A level of different AHI groups before and after operation(mild group:(0.33±0.02) μg/ml vs (0.28± 0.03) μg/ml,moderate group:(0.39±0.04) μg/ml vs (0.29±0.03) μg/ml,severe group:(0.49±0.04) μg/ml vs (0.32± 0.02) μg/ml),there had significant differences (P＜0.01).In OSAHS children,AHI index had positive correlation with preoperative plasma orexin-A level (r=0.803,P＜0.01).There was a significant negative correlation between sensory integration scores and plasma orexinA level(r=-0.812,P＜0.01).Conclusions Plasma orexin-A level of OSAHS children is closely related to the severity of OSAHS and the changes of their behavioral ability.And it may become a diagnostic plasma marker of OSAHS children.
