中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2014年
1期
25-28
,共4页
花玲玲%姚志剑%李浩然%汤浩%阎锐%陈建淮%卢青
花玲玲%姚誌劍%李浩然%湯浩%閻銳%陳建淮%盧青
화령령%요지검%리호연%탕호%염예%진건회%로청
抑郁症%情绪面孔%脑磁图%动态因果模型
抑鬱癥%情緒麵孔%腦磁圖%動態因果模型
억욱증%정서면공%뇌자도%동태인과모형
Major Depressive disorder%Emotional face%Magnetoencephalography%Dynamic causal model
目的 探究抑郁症患者在识别喜悦表情时前额叶-杏仁核最优效能连接模式,并以此探讨抑郁症前额叶-杏仁核情绪加工可能的异常机制.方法 利用脑磁图检测20例抑郁症患者及20例相匹配的健康对照者在识别动态面部表情时的脑部反应.通过动态因果模型方法选出最优模型,并比较抑郁症组及对照组的效能连接变化.结果 贝叶斯模型选择结果显示,总体最优模型的特征是背外侧前额叶、前扣带回、杏仁核两两存在自上而下的调节连接,模型超越概率为0.41.最优模型中固有连接水平出现组间差异,在固有连接水平上,抑郁症组右侧杏仁核-前扣带回的前向连接显著减弱(t=-2.50,P=0.016),前扣带回-背外侧前额叶的前向连接显著增强(t=2.37,P=0.022),杏仁核-背外侧前额前向连接显著增强(t=2.10,P=0.04).结论 抑郁症患者右侧半球自下而上的固有连接异常,可能与抑郁症患者负性偏向有关;而抑郁症患者处理喜悦面孔时前额叶—杏仁核调制连接并未出现明显异常.
目的 探究抑鬱癥患者在識彆喜悅錶情時前額葉-杏仁覈最優效能連接模式,併以此探討抑鬱癥前額葉-杏仁覈情緒加工可能的異常機製.方法 利用腦磁圖檢測20例抑鬱癥患者及20例相匹配的健康對照者在識彆動態麵部錶情時的腦部反應.通過動態因果模型方法選齣最優模型,併比較抑鬱癥組及對照組的效能連接變化.結果 貝葉斯模型選擇結果顯示,總體最優模型的特徵是揹外側前額葉、前釦帶迴、杏仁覈兩兩存在自上而下的調節連接,模型超越概率為0.41.最優模型中固有連接水平齣現組間差異,在固有連接水平上,抑鬱癥組右側杏仁覈-前釦帶迴的前嚮連接顯著減弱(t=-2.50,P=0.016),前釦帶迴-揹外側前額葉的前嚮連接顯著增彊(t=2.37,P=0.022),杏仁覈-揹外側前額前嚮連接顯著增彊(t=2.10,P=0.04).結論 抑鬱癥患者右側半毬自下而上的固有連接異常,可能與抑鬱癥患者負性偏嚮有關;而抑鬱癥患者處理喜悅麵孔時前額葉—杏仁覈調製連接併未齣現明顯異常.
목적 탐구억욱증환자재식별희열표정시전액협-행인핵최우효능련접모식,병이차탐토억욱증전액협-행인핵정서가공가능적이상궤제.방법 이용뇌자도검측20례억욱증환자급20례상필배적건강대조자재식별동태면부표정시적뇌부반응.통과동태인과모형방법선출최우모형,병비교억욱증조급대조조적효능련접변화.결과 패협사모형선택결과현시,총체최우모형적특정시배외측전액협、전구대회、행인핵량량존재자상이하적조절련접,모형초월개솔위0.41.최우모형중고유련접수평출현조간차이,재고유련접수평상,억욱증조우측행인핵-전구대회적전향련접현저감약(t=-2.50,P=0.016),전구대회-배외측전액협적전향련접현저증강(t=2.37,P=0.022),행인핵-배외측전액전향련접현저증강(t=2.10,P=0.04).결론 억욱증환자우측반구자하이상적고유련접이상,가능여억욱증환자부성편향유관;이억욱증환자처리희열면공시전액협—행인핵조제련접병미출현명현이상.
Objective To investigate whether there is exists optimal effective connections of prefrontal-amygdala in patients with major depressive disorder when they recognize dynamic positive face expressions with the technology of magnetoencephalograph (MEG),and discuss the possible aberrant mechanism of emotion processing.Methods Twenty major depressive patients and 20 well-matched healthy volunteer controls participated in the experiment.The regions of interested brain area included the primary visual cortex (V1),the precuneus (PQ),the dorsolateral prefrontal cortex (DLPFC),the anterior cingulate cortex (ACC),the amygdala (AMYG).After constructing three putative models,dynamic causal model was used to select an optimal model,then extracted all the effective connection parameters and conducted t-test under the overall optimal model between-group comparison.Results The bayesian model selection (BMS) indicated that model with top-down modulate connections between DLPFC-ACC,DLPFC-AMYG and ACC-AMYG was the most superior model,whose exceedance probability was 0.41.In the fight hemisphere of patient group,the endogenous connectivity from AMYG to ACC significantly decreased compared to healthy controls (t=-2.21,P=0.033),while the endogenous connectivity from ACC to DLPFC was enhanced significandy (t=2.50,P=0.017),which was the same with the endogenous connectivity from AMYG to DLPFC (t=2.10,P=0.040).Conclusion The effective connections of prefrontal-amygdala in major depressive disorder are exactly impaired,which may indicate that major depressive disorder have a bias toward negative.While depressed patients don' t show abnormality in the modulate connectivity under happy stimulus.