中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2014年
1期
29-32
,共4页
韩洪瀛%钟智勇%甘照宇%王厚亮%张晋碚%陈晓岗
韓洪瀛%鐘智勇%甘照宇%王厚亮%張晉碚%陳曉崗
한홍영%종지용%감조우%왕후량%장진배%진효강
甲基化CpG结合蛋白-2基因%多态性%女性%精神分裂症%关联研究
甲基化CpG結閤蛋白-2基因%多態性%女性%精神分裂癥%關聯研究
갑기화CpG결합단백-2기인%다태성%녀성%정신분렬증%관련연구
MeCP2 gene%Polymorphism%Female%Schizophrenia%Association study
目的 研究甲基化CpG结合蛋白-2(MeCP2)基因多态性与女性精神分裂症患者的关联性.方法 采用基于质谱微阵列技术的基因多态性分析法对符合DSM-Ⅳ诊断标准的126例精神分裂症患者和144例正常对照组患者MeCP2基因上的4个SNP位点进行基因分型,用x2检验比较上述4个位点的基因型频率和等位基因频率的组间差异.结果 MeCP2基因rs1616369位点G/A基因型分布频率(24.8% vs34.3%)组间差异有统计学意义(R0.05);rs3027933位点G/C基因型分布频率(25.6% vs 34.8%)组间差异有统计学意义(P<0.05);位点rs17435基因型T/A分布频率(25.6% vs 35.5%)组间差异有统计学意义(P<0.05);位点rs2239464基因型A/A分布频率(58.5% vs 71.8%),组间差异有统计学意义(P<0.05);单体型GCCA分布频率在病例组为0.1581,在对照组为0.2389,组间差异有统计学意义(P<0.05).结论 女性精神分裂症患者MeCP2基因的相关基因型可能跟精神分裂症发病有相关性,MeCP2基因可能是女性精神分裂症易感基因,单体型GCCA可能是女性精神分裂症发病的保护因素.
目的 研究甲基化CpG結閤蛋白-2(MeCP2)基因多態性與女性精神分裂癥患者的關聯性.方法 採用基于質譜微陣列技術的基因多態性分析法對符閤DSM-Ⅳ診斷標準的126例精神分裂癥患者和144例正常對照組患者MeCP2基因上的4箇SNP位點進行基因分型,用x2檢驗比較上述4箇位點的基因型頻率和等位基因頻率的組間差異.結果 MeCP2基因rs1616369位點G/A基因型分佈頻率(24.8% vs34.3%)組間差異有統計學意義(R0.05);rs3027933位點G/C基因型分佈頻率(25.6% vs 34.8%)組間差異有統計學意義(P<0.05);位點rs17435基因型T/A分佈頻率(25.6% vs 35.5%)組間差異有統計學意義(P<0.05);位點rs2239464基因型A/A分佈頻率(58.5% vs 71.8%),組間差異有統計學意義(P<0.05);單體型GCCA分佈頻率在病例組為0.1581,在對照組為0.2389,組間差異有統計學意義(P<0.05).結論 女性精神分裂癥患者MeCP2基因的相關基因型可能跟精神分裂癥髮病有相關性,MeCP2基因可能是女性精神分裂癥易感基因,單體型GCCA可能是女性精神分裂癥髮病的保護因素.
목적 연구갑기화CpG결합단백-2(MeCP2)기인다태성여녀성정신분렬증환자적관련성.방법 채용기우질보미진렬기술적기인다태성분석법대부합DSM-Ⅳ진단표준적126례정신분렬증환자화144례정상대조조환자MeCP2기인상적4개SNP위점진행기인분형,용x2검험비교상술4개위점적기인형빈솔화등위기인빈솔적조간차이.결과 MeCP2기인rs1616369위점G/A기인형분포빈솔(24.8% vs34.3%)조간차이유통계학의의(R0.05);rs3027933위점G/C기인형분포빈솔(25.6% vs 34.8%)조간차이유통계학의의(P<0.05);위점rs17435기인형T/A분포빈솔(25.6% vs 35.5%)조간차이유통계학의의(P<0.05);위점rs2239464기인형A/A분포빈솔(58.5% vs 71.8%),조간차이유통계학의의(P<0.05);단체형GCCA분포빈솔재병례조위0.1581,재대조조위0.2389,조간차이유통계학의의(P<0.05).결론 녀성정신분렬증환자MeCP2기인적상관기인형가능근정신분렬증발병유상관성,MeCP2기인가능시녀성정신분렬증역감기인,단체형GCCA가능시녀성정신분렬증발병적보호인소.
Objective To explore the association of methyl-CpG-binding protein2 (MeCP2) polymorphisms with female schizophrenia in Chinese Han population.Methods By using the technology based on microarray Chip,gene polymorphism analysis of 4 locus located in the gene MeCP2 was performed in 126 schizophrenia patients fulfilled with DSM-Ⅳ-TR criteria for schizophrenia and in 144 healthy controls.Chi square test was used to compare the inter-group differences of genotypic and allelic distribution.Haplotype case-control association analysis based on linkage disequilibrium was conducted using SNP stats online software after the data was screened.The significance of results was corrected by permutation test.Results To the point of Locus rs1616369 which located in Gene MeCP2,the distribution of the genotype G/A between two groups(24.8% vs 34.3%) reached significance (P<0.05) ; rs3027933,genotype G/C(25.6% vs 34.8%),P<0.05 ; rs17435,genotype T/A(25.6% vs 35.5%),P < 0.05 ; rs2239464,genotype C/A (58.5% vs 71.8%),P< 0.05.The distribution prevalence of Haplotype GCCA was 0.1581 in case group,and 0.2389 in control group,reached significant difference(P<0.05).Conclusion As to female MeCP2 gene,the genotype on the four locations might associate with the onset of schizophrenia,MeCP2 might be susceptibility gene of female schizophrenia.The Haplotype GCCA maybe the protective factor.