中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2014年
3期
196-199
,共4页
柴巧莲%明庆森%张芸%贾惠侨%郭骁%杨伯艳%姚树桥
柴巧蓮%明慶森%張蕓%賈惠僑%郭驍%楊伯豔%姚樹橋
시교련%명경삼%장예%가혜교%곽효%양백염%요수교
焦虑症状%5-HTT基因的启动子连锁多态性区域%应激%青少年
焦慮癥狀%5-HTT基因的啟動子連鎖多態性區域%應激%青少年
초필증상%5-HTT기인적계동자련쇄다태성구역%응격%청소년
Anxiety symptoms%Serotonin transporter gene promoter region polymorphism%Stress%Adolescent
目的 探讨5-羟色胺转运体(5-HTT)基因的启动子连锁多态性区域(5-HTTLPR)与应激的交互作用对青少年焦虑症状的预测作用.方法 采用随机整群抽样法抽取长沙252名中学生,初测时,采用青少年生活事件问卷(ALEQ)和儿童青少年多维度焦虑量表(MASC)对其应激生活事件及焦虑症状进行评估,并鉴定其5-HTTLPR的基因型.每隔3个月采用ALEQ和MASC对其进行评估,持续24个月.运用多层线性模型分析检验5-HTTLPR与应激对焦虑症状的交互作用.结果 男性样本中5-HTTLPR对焦虑症状无主效应(β=0.80,P＞0.05),应激对焦虑症状有主效应(β=0.30,P＜0.01)；女性样本中5-HTTLPR对焦虑症状无主效应(β=-0.21,P＞0.05),应激对焦虑症状有主效应(β=0.33,P＜0.01)；5-HTTLPR与应激的交互作用具有统计学意义,即遭受应激事件后,携带5-HTTLPR S等位基因的女性(β=0.11,P＜0.01)和携带L等位基因的男性(β=-0.10,P＜0.01)会表现出更高的焦虑水平.结论 5-HTTLPR与应激的交互作用对青少年的焦虑症状具有预测作用,并且存在性别差异.
目的 探討5-羥色胺轉運體(5-HTT)基因的啟動子連鎖多態性區域(5-HTTLPR)與應激的交互作用對青少年焦慮癥狀的預測作用.方法 採用隨機整群抽樣法抽取長沙252名中學生,初測時,採用青少年生活事件問捲(ALEQ)和兒童青少年多維度焦慮量錶(MASC)對其應激生活事件及焦慮癥狀進行評估,併鑒定其5-HTTLPR的基因型.每隔3箇月採用ALEQ和MASC對其進行評估,持續24箇月.運用多層線性模型分析檢驗5-HTTLPR與應激對焦慮癥狀的交互作用.結果 男性樣本中5-HTTLPR對焦慮癥狀無主效應(β=0.80,P＞0.05),應激對焦慮癥狀有主效應(β=0.30,P＜0.01)；女性樣本中5-HTTLPR對焦慮癥狀無主效應(β=-0.21,P＞0.05),應激對焦慮癥狀有主效應(β=0.33,P＜0.01)；5-HTTLPR與應激的交互作用具有統計學意義,即遭受應激事件後,攜帶5-HTTLPR S等位基因的女性(β=0.11,P＜0.01)和攜帶L等位基因的男性(β=-0.10,P＜0.01)會錶現齣更高的焦慮水平.結論 5-HTTLPR與應激的交互作用對青少年的焦慮癥狀具有預測作用,併且存在性彆差異.
목적 탐토5-간색알전운체(5-HTT)기인적계동자련쇄다태성구역(5-HTTLPR)여응격적교호작용대청소년초필증상적예측작용.방법 채용수궤정군추양법추취장사252명중학생,초측시,채용청소년생활사건문권(ALEQ)화인동청소년다유도초필량표(MASC)대기응격생활사건급초필증상진행평고,병감정기5-HTTLPR적기인형.매격3개월채용ALEQ화MASC대기진행평고,지속24개월.운용다층선성모형분석검험5-HTTLPR여응격대초필증상적교호작용.결과 남성양본중5-HTTLPR대초필증상무주효응(β=0.80,P＞0.05),응격대초필증상유주효응(β=0.30,P＜0.01)；녀성양본중5-HTTLPR대초필증상무주효응(β=-0.21,P＞0.05),응격대초필증상유주효응(β=0.33,P＜0.01)；5-HTTLPR여응격적교호작용구유통계학의의,즉조수응격사건후,휴대5-HTTLPR S등위기인적녀성(β=0.11,P＜0.01)화휴대L등위기인적남성(β=-0.10,P＜0.01)회표현출경고적초필수평.결론 5-HTTLPR여응격적교호작용대청소년적초필증상구유예측작용,병차존재성별차이.
Objective To explore the interaction between a serotonin transporter gene promoter region polymorphism(5-HTTPR) and stress in predicting anxiety symptoms.Methods Through random cluster sampling,a total of 252 healthy adolescents participated in this study.During the initial assessment,all participants completed the Adolescent Life Events Questionnaire (ALEQ) and Multidimensional Anxiety Scale for Children (MASC) to assess their levels of stress and anxiety and were genotyped for the 5-HTTLPR polymorphism.Participants subsequently completed MASC and ALEQ once every three months during the subsequent 24 months.A multilevel model was used to investigate the interaction between 5-HTTLPR and stress that predict anxiety symptoms.Results The results indicated no major effect of 5-HTTLPR in males (β=0.80,P＞0.05)or females(β=-0.21,P＞0.05).There were major effects of stress in males(β=0.30,P＜0.01) and females (β=0.33,P＜0.01)and a significant interaction between 5-HTTLPR and stress.Females with at least one 5-HTTLPR S allele(β=0.11,P＜ 0.01)and males with at least one 5-HTTLPR L allele(β=-0.10,P＜0.01)exhibited more anxiety symptoms under stressful situations.Conclusion The interaction between 5-HTTLPR and stress can predict anxiety symptoms in adolescents.There are gender differences on the 5-HTTLPR × stress interaction.
