中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2014年
3期
203-206
,共4页
精神分裂症%GRM7基因%单核苷酸多态性%关联性研究
精神分裂癥%GRM7基因%單覈苷痠多態性%關聯性研究
정신분렬증%GRM7기인%단핵감산다태성%관련성연구
Schizophrenia%GRM7 gene%Single nucleotide polymorphism%Association study
目的 探讨GRM7基因多态性与中国维吾尔族人群中精神分裂症的关联.方法 利用Taqman探针分型技术对360例维吾尔族精神分裂症患者及384例维吾尔族非精神分裂症对照进行GRM7基因rs3749380位点基因分型,使用阳性和阴性症状量表对精神分裂症患者进行临床精神病性症状的评定,利用SHEsis、SPSS 17.0软件系统进行统计分析.结果 在病例组中,GRM7基因rs3749380位点的C等位基因频率为60.1％,T等位基因频率为39,9％,对照组中C等位基因频率为58.6％,T等位基因频率为41.4％；病例组中C/C基因型频率为38.6％,T/C基因型频率为43.1％,T/T基因型频率为18.3％,对照组中C/C基因型频率为35.9％,T/C基因型频率为45.4％,T/T基因型频率为18.7％,两组间rs3749380位点基因型与等位基因频率差异无统计学意义(P＞0.05)；青少年病例组与成年病例组间,青少年病例组与青少年对照组,成年病例组与成年对照组间,rs3749380位点基因型与等位基因频率差异无统计学意义(P＞0.05)；不同性别病例组与对照组间,rs3749380位点基因型与等位基因频率差异无统计学意义(P＞0.05)；各基因型与精神分裂症症状无明显相关性(P＞0.05).结论 GRM7基因rs3749380多态性和中国维吾尔族人群精神分裂症的发病无明显关联.
目的 探討GRM7基因多態性與中國維吾爾族人群中精神分裂癥的關聯.方法 利用Taqman探針分型技術對360例維吾爾族精神分裂癥患者及384例維吾爾族非精神分裂癥對照進行GRM7基因rs3749380位點基因分型,使用暘性和陰性癥狀量錶對精神分裂癥患者進行臨床精神病性癥狀的評定,利用SHEsis、SPSS 17.0軟件繫統進行統計分析.結果 在病例組中,GRM7基因rs3749380位點的C等位基因頻率為60.1％,T等位基因頻率為39,9％,對照組中C等位基因頻率為58.6％,T等位基因頻率為41.4％；病例組中C/C基因型頻率為38.6％,T/C基因型頻率為43.1％,T/T基因型頻率為18.3％,對照組中C/C基因型頻率為35.9％,T/C基因型頻率為45.4％,T/T基因型頻率為18.7％,兩組間rs3749380位點基因型與等位基因頻率差異無統計學意義(P＞0.05)；青少年病例組與成年病例組間,青少年病例組與青少年對照組,成年病例組與成年對照組間,rs3749380位點基因型與等位基因頻率差異無統計學意義(P＞0.05)；不同性彆病例組與對照組間,rs3749380位點基因型與等位基因頻率差異無統計學意義(P＞0.05)；各基因型與精神分裂癥癥狀無明顯相關性(P＞0.05).結論 GRM7基因rs3749380多態性和中國維吾爾族人群精神分裂癥的髮病無明顯關聯.
목적 탐토GRM7기인다태성여중국유오이족인군중정신분렬증적관련.방법 이용Taqman탐침분형기술대360례유오이족정신분렬증환자급384례유오이족비정신분렬증대조진행GRM7기인rs3749380위점기인분형,사용양성화음성증상량표대정신분렬증환자진행림상정신병성증상적평정,이용SHEsis、SPSS 17.0연건계통진행통계분석.결과 재병례조중,GRM7기인rs3749380위점적C등위기인빈솔위60.1％,T등위기인빈솔위39,9％,대조조중C등위기인빈솔위58.6％,T등위기인빈솔위41.4％；병례조중C/C기인형빈솔위38.6％,T/C기인형빈솔위43.1％,T/T기인형빈솔위18.3％,대조조중C/C기인형빈솔위35.9％,T/C기인형빈솔위45.4％,T/T기인형빈솔위18.7％,량조간rs3749380위점기인형여등위기인빈솔차이무통계학의의(P＞0.05)；청소년병례조여성년병례조간,청소년병례조여청소년대조조,성년병례조여성년대조조간,rs3749380위점기인형여등위기인빈솔차이무통계학의의(P＞0.05)；불동성별병례조여대조조간,rs3749380위점기인형여등위기인빈솔차이무통계학의의(P＞0.05)；각기인형여정신분렬증증상무명현상관성(P＞0.05).결론 GRM7기인rs3749380다태성화중국유오이족인군정신분렬증적발병무명현관련.
Objective To investigate the association between GRM7 gene polymorphism and schizophrenia in the Uygur Chinese population.Methods rs3749380 at the GRM7 gene was selected for genotyping in a Uygur Chinese patients-control sample(case=360,control=384) by Taqman assays.The symptoms of schizophrenia were assessed by positive and negative syndrome scale(PANSS).SHEsis on line and SPSS 17.0 soft were used for calculating the data.Results For rs3749380 at GRM7 gene,the C allele frequency was 60.1％,and T allele frequency was 39.9％ in the patients.In the control,the C allele frequency was 58.6％,and T allele frequency was 41.4％.In the patients,the C/C genotype frequency was 38.6％,T/C genotype frequency was 43.1％,and T/T genotype frequency was 18.3％.In the controls,the C/C genotype frequency was 35.9％,T/C genotype frequency was 45.4％,and T/T genotype frequency was 18.7％.rs3749380 was not found to have genotypic or allelic association with schizophrenia(P＞0.05).And genotypic or allelic association with schizophrenia were not found between adolescent and adult cases,adolescent cases and controls or adult cases and controls(P＞0.05).The results showed rs3749380 genotypic or allelic was not association with schizophrenia in the different gender of the population (P＞ 0.05).The genotypes were not significantly correlated with symptoms of schizophrenia(P＞0.05).Conclusion There is no association of GRM7 gene rs3749380 polymorphism with the incidence of schizophrenia in Uygur Chinese.
