中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2014年
3期
248-250
,共3页
曹佩%高芃%马宁%李晨汐%冯永全%支媛%徐海滨
曹珮%高芃%馬寧%李晨汐%馮永全%支媛%徐海濱
조패%고봉%마저%리신석%풍영전%지원%서해빈
溴氰菊酯%亚慢性%学习记忆%Morris迷宫
溴氰菊酯%亞慢性%學習記憶%Morris迷宮
추청국지%아만성%학습기억%Morris미궁
Deltamethrin%Sub-chronic%Learning and memory%Morris water maze
目的 研究溴氰菊酯(DM)亚慢性染毒对小鼠空间学习记忆的影响.方法 清洁级雌性昆明小鼠60只,分为4组,通过灌胃连续染毒60 d.采用Morris水迷宫实验评价小鼠的空间学习记忆能力.结果 DM亚慢性染毒后,定位航行试验中第5天溶剂对照组和各剂量组小鼠的平均逃避潜伏期分别为(12.20±6.5)s、(14.99±5.4)s、(15.64±8.3)s、(22.71±6.2)s.两两比较高剂量组小鼠的逃避潜伏期明显高于低剂量组(P=0.0041)和溶剂对照组(P=0.019).空间探索试验,与溶剂对照组(5.87±1.55)次和低剂量组(4.90±1.41)次相比,中剂量组和高剂量组小鼠穿越原平台位置的次数分别为(3.40±112)次和(2.93±1.53)次,显著低于溶剂对照组和低剂量组(P,＜0.05).结论 DM亚慢性染毒可引起小鼠空间学习和记忆功能损伤.
目的 研究溴氰菊酯(DM)亞慢性染毒對小鼠空間學習記憶的影響.方法 清潔級雌性昆明小鼠60隻,分為4組,通過灌胃連續染毒60 d.採用Morris水迷宮實驗評價小鼠的空間學習記憶能力.結果 DM亞慢性染毒後,定位航行試驗中第5天溶劑對照組和各劑量組小鼠的平均逃避潛伏期分彆為(12.20±6.5)s、(14.99±5.4)s、(15.64±8.3)s、(22.71±6.2)s.兩兩比較高劑量組小鼠的逃避潛伏期明顯高于低劑量組(P=0.0041)和溶劑對照組(P=0.019).空間探索試驗,與溶劑對照組(5.87±1.55)次和低劑量組(4.90±1.41)次相比,中劑量組和高劑量組小鼠穿越原平檯位置的次數分彆為(3.40±112)次和(2.93±1.53)次,顯著低于溶劑對照組和低劑量組(P,＜0.05).結論 DM亞慢性染毒可引起小鼠空間學習和記憶功能損傷.
목적 연구추청국지(DM)아만성염독대소서공간학습기억적영향.방법 청길급자성곤명소서60지,분위4조,통과관위련속염독60 d.채용Morris수미궁실험평개소서적공간학습기억능력.결과 DM아만성염독후,정위항행시험중제5천용제대조조화각제량조소서적평균도피잠복기분별위(12.20±6.5)s、(14.99±5.4)s、(15.64±8.3)s、(22.71±6.2)s.량량비교고제량조소서적도피잠복기명현고우저제량조(P=0.0041)화용제대조조(P=0.019).공간탐색시험,여용제대조조(5.87±1.55)차화저제량조(4.90±1.41)차상비,중제량조화고제량조소서천월원평태위치적차수분별위(3.40±112)차화(2.93±1.53)차,현저저우용제대조조화저제량조(P,＜0.05).결론 DM아만성염독가인기소서공간학습화기억공능손상.
Objective To study the effect of sub-chronic exposure to dehamethrin(DM) on the behavior of mice in learning and memory.Methods 60 Female SPF Kunming mice were randomly divided into 4 groups and given DM by gavaging for 60 days.Morris water maze (MWM) was used to evaluate spatial memory in mice.Results After exposure to DM,the escape latency of the solvent control group and the treatment groups were (12.20±6.5)s,(14.99±5.4) s,(15.64±8.3)s,(22.71±6.2)s on the fifth day.The escape latency of the high-dose group was higher than those of the low-dose group (P=0.0041) and the solvent control group (P=0.019) in the navigation test.The number of crossing position of the platform in the high-dose group ((2.93± 1.53)times) and the middle-dose group ((3.40± 1.12) times) were lower than that in the solvent control group ((5.87 ± 1.55) times) and the low-dose group ((4.90± 1.41)times)(P＜0.05).Conclusion Sub-chronic exposure to DM can damage the spatial learning and memory of mice.
