CAJ | 학술논문

目的探讨内化心理障碍患者错误相关负波特征和诊断价值.方法从门诊和住院患者中筛选符合DSM-Ⅳ焦虑或抑郁障碍患者55人(内化障碍组),选择正常对照20人(对照组).以Eriksen任务和Simon任务作为诱发刺激,应用加拿大Stellate-64导EEG/ERP分析仪和BESA5.2软件获取错误相关负波(ERN),同时收集一般资料、临床症状、反应时和错误率等行为资料.结果 (1)在Eriksen任务和Si-mon任务上,内化障碍组正确反应时[(377.5±98.8)ms]和错误反应时[(337.3±96.6) ms]显著长于对照组[(288.5±105.9) ms和(281.9±94.3) ms],其它指标组间差异无统计学意义(P＞0.05);(2)内化障碍组Eriksen任务6个位点的ERN波幅[(Fz=(4.97±5.74) μV,F3=(5.50±4.59) μV,F4=(6.26±6.79) μV,Cz=(4.74±5.51) μV,C3=(5.44±4.80) μV,C4=(5.50±5.28) μV]均显著大于对照组[(1.17±1.47) μV,(2.22±3.95) μV,(3.40±2.55) μV,(2.28± 1.41) μV,(3.05±2.47) μV,(3.16± 2.51) μμV],在Simon任务中仅Fz位点[(5.43±6.61) μV]和F4位点[(6.00±5.50) μV]的ERN波幅显著大于对照组[(2.05±2.34) μV,(3.09±2.86) μV],其它位点组间差异无统计学意义(P＞0.05);(3)内化障碍组Simon任务Fz和F4位点ERN潜伏期[(87.6±34.4) ms和(84.9± 34.8) ms]显著长于对照组[(54.0±46.5) ms和(36.3±42.4) ms],其它位点组间差异无统计学意义(P＞0.05).结论内化心理障碍患者错误相关负波增大,提示患者存在内部错误监控缺陷,ERN可能是内化心理障碍的内表型指标.
목적 탐토내화심리장애환자착오상관부파특정화진단개치.방법 종문진화주원환자중사선부합DSM-Ⅳ초필혹억욱장애환자55인(내화장애조),선택정상대조20인(대조조).이Eriksen임무화Simon임무작위유발자격,응용가나대Stellate-64도EEG/ERP분석의화BESA5.2연건획취착오상관부파(ERN),동시수집일반자료、림상증상、반응시화착오솔등행위자료.결과 (1)재Eriksen임무화Si-mon임무상,내화장애조정학반응시[(377.5±98.8)ms]화착오반응시[(337.3±96.6) ms]현저장우대조조[(288.5±105.9) ms화(281.9±94.3) ms],기타지표조간차이무통계학의의(P＞0.05);(2)내화장애조Eriksen임무6개위점적ERN파폭[(Fz=(4.97±5.74) μV,F3=(5.50±4.59) μV,F4=(6.26±6.79) μV,Cz=(4.74±5.51) μV,C3=(5.44±4.80) μV,C4=(5.50±5.28) μV]균현저대우대조조[(1.17±1.47) μV,(2.22±3.95) μV,(3.40±2.55) μV,(2.28± 1.41) μV,(3.05±2.47) μV,(3.16± 2.51) μμV],재Simon임무중부Fz위점[(5.43±6.61) μV]화F4위점[(6.00±5.50) μV]적ERN파폭현저대우대조조[(2.05±2.34) μV,(3.09±2.86) μV],기타위점조간차이무통계학의의(P＞0.05);(3)내화장애조Simon임무Fz화F4위점ERN잠복기[(87.6±34.4) ms화(84.9± 34.8) ms]현저장우대조조[(54.0±46.5) ms화(36.3±42.4) ms],기타위점조간차이무통계학의의(P＞0.05).결론 내화심리장애환자착오상관부파증대,제시환자존재내부착오감공결함,ERN가능시내화심리장애적내표형지표.
Objective To investigate error-related negativity characteristics of patients with internalizing mental disorders and its diagnostic value.Methods Fifty-five patients met with DSM-Ⅳ anxiety or depression criteria were sampled from outpatients and inpatients,and 20 normal adults were selected as control group.With Eriksen and Simon tasks as evoked stimuli,error-related negativities of each participant were acquired using Canada Stellate-64 channel EEG/ERP Instrument and BESA5.2 software,and the data of general information,clinical symptoms,reaction time,and error rate were collected.Results (1) Correct reaction time ((377.5±98.8) ms)and errors reaction time ((337.3±96.6)ms) of patient group were significantly longer than those of control group ((288.5±105.9)ms and (281.9±94.3)ms) on the Eriksen task and Simon task,and there were no significantly group differences on other indicators (P＞0.05).(2) ERN amplitudes at 6 sities (Fz =(4.97±5.74) μV,F3 =(5.50±4.59) μV,F4 =(6.26±6.79) μV,Cz =(4.74±5.51) μV,C3 =(5.44±4.8) μV,C4 =(5.50± 5.28) μV) of patients group were significantly greater than those of control group ((1.17± 1.47)μV,(2.22±3.95) μV,(3.40±2.55)μV,(2.28± 1.41) μV,(3.05±2.47) μV,(3.16±2.51) μV) on the Eriksen task.ERN amplitudes at Fz((5.43±6.61) μV) and F4((6.00±5.50)μV) of patient group were significantly were greater than those of control group ((2.05 ±2.34) μV,(3.09±2.86)μV) on the Simon task,and there were no significantly group differences on the ERN amplitudes at other sites (P＞0.05).(3) ERN latencies ((87.6±34.4) ms and (84.9±34.8) ms) of patient group at Fz and F4 were significantly longer than control group ((54.0±46.5) ms and (36.3±42.4)ms) on the Simon task,and there were no significantly group differences on the ERN latencies at other sites (P＞0.05).Conclusion The increased error related potentials suggest that patients with internalizing mental disorders has an internal error monitoring defects,and ERN might be a useful endophenotype for internalizing mental disorders.