中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2014年
4期
323-326
,共4页
冯玉%戴媛媛%吉峰%杨志寅
馮玉%戴媛媛%吉峰%楊誌寅
풍옥%대원원%길봉%양지인
抑郁症%认知障碍%脑源性神经营养因子%单核苷酸多态性
抑鬱癥%認知障礙%腦源性神經營養因子%單覈苷痠多態性
억욱증%인지장애%뇌원성신경영양인자%단핵감산다태성
Depression%Cognitive dysfunction%Brain-derived neurotrophic factor%Single nucleotide polymorphism
目的 探讨脑源性神经营养因子(BDNF)基因与抑郁症患者认知功能障碍的关系.方法 采用北京版蒙特利尔认知评估量表(MoCA-BJ)分别对73例抑郁症患者和66例正常人进行认知功能评定,根据MoCA-BJ得分,将抑郁症患者划分为伴认知功能障碍组(36例)和不伴认知功能障碍组(37例);采用PCR-RFLP技术,检测BDNF基因rs6265及rs12273539两个SNPs位点的基因型.结果 3组之间rs6265位点基因型分布(x2=5.18,P=0.27)、A等位基因携带频率(x2=4.28,P=0.12)、G等位基因携带频率(x2=1.95,P=0.38)差异无统计学意义;不伴认知功能障碍组与健康对照组在rs12273539位点基因型分布,等位基因携带频率上差异无统计学意义(P＞0.05);而伴认知功能障碍组与健康对照组的rs12273539位点基因型分布差异有统计学意义(x2=8.38,P=0.02),C等位基因携带频率显著高于对照组(x2=5.40,P=0.02),T等位基因携带频率低于对照组(x2=6.06,P=0.01);注意功能在CC、CT、TT三种基因型间的分值差异具有统计学意义(P＜0.01).结论 BDNF rs12273539(T/C)基因型与抑郁症患者认知障碍相关,伴认知功能障碍的抑郁症患者比健康对照组携带更多的C等位基因;CC基因型的抑郁症患者注意功能的损害更为严重.
目的 探討腦源性神經營養因子(BDNF)基因與抑鬱癥患者認知功能障礙的關繫.方法 採用北京版矇特利爾認知評估量錶(MoCA-BJ)分彆對73例抑鬱癥患者和66例正常人進行認知功能評定,根據MoCA-BJ得分,將抑鬱癥患者劃分為伴認知功能障礙組(36例)和不伴認知功能障礙組(37例);採用PCR-RFLP技術,檢測BDNF基因rs6265及rs12273539兩箇SNPs位點的基因型.結果 3組之間rs6265位點基因型分佈(x2=5.18,P=0.27)、A等位基因攜帶頻率(x2=4.28,P=0.12)、G等位基因攜帶頻率(x2=1.95,P=0.38)差異無統計學意義;不伴認知功能障礙組與健康對照組在rs12273539位點基因型分佈,等位基因攜帶頻率上差異無統計學意義(P＞0.05);而伴認知功能障礙組與健康對照組的rs12273539位點基因型分佈差異有統計學意義(x2=8.38,P=0.02),C等位基因攜帶頻率顯著高于對照組(x2=5.40,P=0.02),T等位基因攜帶頻率低于對照組(x2=6.06,P=0.01);註意功能在CC、CT、TT三種基因型間的分值差異具有統計學意義(P＜0.01).結論 BDNF rs12273539(T/C)基因型與抑鬱癥患者認知障礙相關,伴認知功能障礙的抑鬱癥患者比健康對照組攜帶更多的C等位基因;CC基因型的抑鬱癥患者註意功能的損害更為嚴重.
목적 탐토뇌원성신경영양인자(BDNF)기인여억욱증환자인지공능장애적관계.방법 채용북경판몽특리이인지평고량표(MoCA-BJ)분별대73례억욱증환자화66례정상인진행인지공능평정,근거MoCA-BJ득분,장억욱증환자화분위반인지공능장애조(36례)화불반인지공능장애조(37례);채용PCR-RFLP기술,검측BDNF기인rs6265급rs12273539량개SNPs위점적기인형.결과 3조지간rs6265위점기인형분포(x2=5.18,P=0.27)、A등위기인휴대빈솔(x2=4.28,P=0.12)、G등위기인휴대빈솔(x2=1.95,P=0.38)차이무통계학의의;불반인지공능장애조여건강대조조재rs12273539위점기인형분포,등위기인휴대빈솔상차이무통계학의의(P＞0.05);이반인지공능장애조여건강대조조적rs12273539위점기인형분포차이유통계학의의(x2=8.38,P=0.02),C등위기인휴대빈솔현저고우대조조(x2=5.40,P=0.02),T등위기인휴대빈솔저우대조조(x2=6.06,P=0.01);주의공능재CC、CT、TT삼충기인형간적분치차이구유통계학의의(P＜0.01).결론 BDNF rs12273539(T/C)기인형여억욱증환자인지장애상관,반인지공능장애적억욱증환자비건강대조조휴대경다적C등위기인;CC기인형적억욱증환자주의공능적손해경위엄중.
Objective To explore the relationship between polymorphisms of brain-derived neurotrophic factor(BDNF) gene (rs6265 and rs12273539) and cognitive impairment in depressive disorder.Methods All participants including 73 depressed patients and 71 healthy controls were received clinical and cognitive assessments at admission,and then the depression group was divided into two groups by the score of Beijing version of the Montreal Cognitive Assessment (MoCA-BJ).One was depression with cognitive dysfunction group,and the other was depression without cognitive dysfunction group,with 36 and 37 cases respectively.The polymorphisms of BDNF gene was identified by PCR-RFLP.Results No significant difference for rs6265 gene types(x2=5.18,P=0.27),A allele carries (x2 =4.28,P=0.12) and G allele carries (x2 =1.95,P=0.38) among the three groups.There was no significant difference for rs12273539 gene types,allele carries between patients without cognitive dysfunction and controls groups(P＞0.05).There was much more C-allele carries (x2=5.40,P=0.02)and less T-allele(x2=6.06,P=0.01) in patients with cognitive disorder than those in health and it was different in rs12273539 gene types between the two groups(x2=8.38,P=0.02).CC/CT/CT gene type performed different on attention function (P＜0.01).Conclusion BDNF rsl2273539(T/C) gene type has relationship with the onset of cognitive disorder in depressed patients,and there are more C-allele carries in depressive patients.The depression patients with CC gene type are worse on the attention function impairement.
