CAJ | 학술논문

目的比较文拉法辛和米氮平治疗难治性抑郁症的成本-效果和成本-效用.方法研究纳入难治性抑郁症患者105例,按照计算机生成的随机数随机分为文拉法辛组50例和米氮平组55例.计算8周治疗药费成本,以临床治愈率和临床有效率为治疗效果,质量调整生命年为治疗效用.采用描述性分析及非参数检验比较两组的成本-效果和成本-效用.结果治疗8周每位抑郁症患者治疗成本文拉法辛组1 396.44元,米氮平组1 206.90元,前者比后者成本高189.54元.成本-效果分析显示,两组每成功治愈或治疗有效1％患者的成本接近(临床治愈率成本相差0.06元,临床有效率成本相差1.08元).成本-效用分析显示两组之间差异无统计学意义(生理机能Z=-0.15,P＞0.05;心理健康Z=-0.54,P＞0.05).结论文拉法辛和米氮平治疗难治性抑郁症的成本-效果、成本-效用相似.
목적 비교문랍법신화미담평치료난치성억욱증적성본-효과화성본-효용.방법 연구납입난치성억욱증환자105례,안조계산궤생성적수궤수수궤분위문랍법신조50례화미담평조55례.계산8주치료약비성본,이림상치유솔화림상유효솔위치료효과,질량조정생명년위치료효용.채용묘술성분석급비삼수검험비교량조적성본-효과화성본-효용.결과 치료8주매위억욱증환자치료성본문랍법신조1 396.44원,미담평조1 206.90원,전자비후자성본고189.54원.성본-효과분석현시,량조매성공치유혹치료유효1％환자적성본접근(림상치유솔성본상차0.06원,림상유효솔성본상차1.08원).성본-효용분석현시량조지간차이무통계학의의(생리궤능Z=-0.15,P＞0.05;심리건강Z=-0.54,P＞0.05).결론 문랍법신화미담평치료난치성억욱증적성본-효과、성본-효용상사.
Objective To compare the cost-effectiveness and cost-utility of venlafaxine and mirtazapine in patients with treatment-resistant major depression (TRD).Methods One hundred and five patients with TRD were enrolled in this study and grouped into venlafaxine treatment (n=50) and mirtazapine treatment (n=55) based on the double-blind randomization scheme generated by computer.The treatment costs of antidepressants during 8 weeks were calculated,the rates of clinical response and remission were taken as treatment effectiveness,and the quality-adjusted life years (QALYs) as treatment utility.The descriptive analysis and nonparametric test were used to compare the cost-effectiveness and cost-utility of different groups.Results During 8 weeks,the treatment cost of antidepressant was ￥ 1 396.44 for venlafaxine and ￥ 1 206.90 mirtazapine,and the difference between two groups was ￥ 189.54.The cost-effectiveness ratios between venlafaxine and mirtazapine were very close (differed ￥ 0.06 for remission rate and ￥ 1.08 for response rate respectively).There was no significant difference for cost-utility ratios between two groups (physical functioning Z=-0.15,P＞0.05 ; mental health Z=-0.54,P＞0.05).Conclusion Both cost-effectiveness and cost-utility of venlafaxine in patients with TRD are close between venlafaxine and mirtazapine.