CAJ | 학술논문

目的对广泛性焦虑障碍(GAD)患者行磁共振弥散加权成像(DWI)检测,以了解其白质微结构的改变情况.方法选符合条件的19例GAD患者为GAD组,20例条件匹配的正常人为健康对照组,所有受试者在3.0T超导磁共振成像系统上进行DWI扫描,在弥散敏感系数b值为1000 s/mm2(b value of 1000 s/mm2)时,测量感兴趣区的表观弥散系数(ADC)值和指数化弥散系数(eADC)值,并进行两组比较.感兴趣区域包括双侧扣带回和双侧海马的白质.结果 GAD组右、左侧扣带回前部白质的ADC值(0.78±0.02,0.79±0.03)明显高于对照组,差异有统计学意义(P＜0.05),eADC值(0.46±0.01,0.45±0.01)明显低于对照组,差异有统计学意义(P＜0.05).其余被检查的脑区两组未见差异.结论 GAD患者在扣带回部位存在脑白质微结构的损害.
목적 대엄범성초필장애(GAD)환자행자공진미산가권성상(DWI)검측,이료해기백질미결구적개변정황.방법 선부합조건적19례GAD환자위GAD조,20례조건필배적정상인위건강대조조,소유수시자재3.0T초도자공진성상계통상진행DWI소묘,재미산민감계수b치위1000 s/mm2(b value of 1000 s/mm2)시,측량감흥취구적표관미산계수(ADC)치화지수화미산계수(eADC)치,병진행량조비교.감흥취구역포괄쌍측구대회화쌍측해마적백질.결과 GAD조우、좌측구대회전부백질적ADC치(0.78±0.02,0.79±0.03)명현고우대조조,차이유통계학의의(P＜0.05),eADC치(0.46±0.01,0.45±0.01)명현저우대조조,차이유통계학의의(P＜0.05).기여피검사적뇌구량조미견차이.결론 GAD환자재구대회부위존재뇌백질미결구적손해.
Objective To examine the white matter microstructure alternations in the patients with generalized anxiety disorder (GAD) with diffusion weighted imaging.Methods 19 patients with GAD and 20 matched healthy controls were assessed using apparent diffusion coefficient (ADC) and exponential apparent diffusion coefficient (eADC) in the regions of interests (ROIs) approach.The ROIs were the white matter of bilateral cingulate and bilateral hippocampus.Results Significantly increased ADC values were found in GAD patients (0.78±0.02,0.79±0.03) with respect to normal controls in the right and left anterior cingulate white matter.Significantly decreased eADC values were found in GAD patients (0.46±0.01,0.45±0.01) in the right and left anterior cingulate white matter.Conclusion Diffuse cingulate white matter alterations on DWI in GAD denote the disruption of white matter integrity.