中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2014年
7期
601-604
,共4页
于翠玉%刘卫国%陈伶%冯芜若
于翠玉%劉衛國%陳伶%馮蕪若
우취옥%류위국%진령%풍무약
帕金森病%认知功能损害%随访研究%蒙特利尔认知评估量表
帕金森病%認知功能損害%隨訪研究%矇特利爾認知評估量錶
파금삼병%인지공능손해%수방연구%몽특리이인지평고량표
Parkinson's disease%Cognitive impairment%Follow-up%MoCA
目的 随访研究帕金森病(parkinson's disease,PD)患者认知功能的变化并研究患者认知功能下降的相关因素.方法 应用蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)评估70例原发性PD患者的认知功能,联合应用PD相关量表评定其运动症状及抑郁、焦虑等非运动症状,并收集患者与PD相关的个人信息.2012年对患者进行随访,再次进行各量表评估,收集两次调查数据进行分析.结果 两年后,患者MoCA总分从(24.79±4.07)分降至(21.69±5.22)分,差异有统计学意义(P＜0.01),其中MoCA 7个认知领域中5个认知领域总分下降达到统计学差异.PD运动亚型是认知功能下降最主要的预测因素(P＜0.01).与震颤(tremor dominant,TD)型比较,姿势和步态异常(postural instability gait difficulty,PIGD)型在MoCA总分及命名、语言、抽象和定向领域下降更加明显.结论 PD患者经过两年病程发展认知功能有明显下降,应及早注意鉴别患者运动亚型、识别患者认知功能的下降并进行干预.
目的 隨訪研究帕金森病(parkinson's disease,PD)患者認知功能的變化併研究患者認知功能下降的相關因素.方法 應用矇特利爾認知評估量錶(Montreal Cognitive Assessment,MoCA)評估70例原髮性PD患者的認知功能,聯閤應用PD相關量錶評定其運動癥狀及抑鬱、焦慮等非運動癥狀,併收集患者與PD相關的箇人信息.2012年對患者進行隨訪,再次進行各量錶評估,收集兩次調查數據進行分析.結果 兩年後,患者MoCA總分從(24.79±4.07)分降至(21.69±5.22)分,差異有統計學意義(P＜0.01),其中MoCA 7箇認知領域中5箇認知領域總分下降達到統計學差異.PD運動亞型是認知功能下降最主要的預測因素(P＜0.01).與震顫(tremor dominant,TD)型比較,姿勢和步態異常(postural instability gait difficulty,PIGD)型在MoCA總分及命名、語言、抽象和定嚮領域下降更加明顯.結論 PD患者經過兩年病程髮展認知功能有明顯下降,應及早註意鑒彆患者運動亞型、識彆患者認知功能的下降併進行榦預.
목적 수방연구파금삼병(parkinson's disease,PD)환자인지공능적변화병연구환자인지공능하강적상관인소.방법 응용몽특리이인지평고량표(Montreal Cognitive Assessment,MoCA)평고70례원발성PD환자적인지공능,연합응용PD상관량표평정기운동증상급억욱、초필등비운동증상,병수집환자여PD상관적개인신식.2012년대환자진행수방,재차진행각량표평고,수집량차조사수거진행분석.결과 량년후,환자MoCA총분종(24.79±4.07)분강지(21.69±5.22)분,차이유통계학의의(P＜0.01),기중MoCA 7개인지영역중5개인지영역총분하강체도통계학차이.PD운동아형시인지공능하강최주요적예측인소(P＜0.01).여진전(tremor dominant,TD)형비교,자세화보태이상(postural instability gait difficulty,PIGD)형재MoCA총분급명명、어언、추상화정향영역하강경가명현.결론 PD환자경과량년병정발전인지공능유명현하강,응급조주의감별환자운동아형、식별환자인지공능적하강병진행간예.
Objective To investigate the change and its related risk factors of cognitive function of patients with Parkinson's disease(PD).Methods The cognitive function of 70 idiopathic PD patients were assessed with Montreal cognitive assessment scale (MoCA),and other PD related neuropsychological test batteries were used to evaluate their movement symptoms and non-movement symptoms such as depression and anxiety.Patients' personal information were collected at the same time.They were reassessed after 2 years.Results As the disease progressed,the MoCA score of the PD patients significantly reduced from (24.79±4.07) points to (21.69±5.22) points (P＜0.01).Seven subdomains of MoCA were attenuated,and 5 of them reached statistical significance.Motor subtype was a main predictor of the outcome of the cognitive impairment in PD.Scores of MoCA total score,naming,language,abstract and directional domains reduced more notably in patients with postural instability gait difficulty(PIGD) than those in the tremor dominant(TD) patients.Conclusion Cognitive function of PD patients decreases obviously after 2 years.The patients' cognitive impairment should be identified and intervened as soon as possible,especially the patients with PIGD.
