CAJ | 학술논문

目的探讨首发抑郁症患者脑局部神经元自发性活动能量特征与临床症状群的相关性.方法对22位首发抑郁患者和26位性别、年龄相匹配的健康对照,进行3.0T磁共振扫描.以受教育年限为协变量,比较两组受试脑区低频振幅(ALFF)值,将有统计学差异的脑区ALFF均值与临床症状群严重程度进行相关分析.结果患者组较对照组右额中回(9,45,-6;K=18)和双侧梭状回(-34,-19,-12;K=37和30,-33,-18;K=31)ALFF值增高,左楔前叶(0,-72,42; K=19)ALFF降低(P＜0.05,Alphasim矫正).右额中回、右梭状回和左楔前叶ALFF值,分别与体质量因子分、阻滞因子分和睡眠障碍因子分呈负相关(r=-0.494,P=0.019;r=-0.486,P=0.022和r=-0.484,P=0.023),其余相关性无统计学意义(P＞0.05).结论首发抑郁症患者特定症状群的严重程度与静息状态下脑局部神经元活动强度异常有关.
목적 탐토수발억욱증환자뇌국부신경원자발성활동능량특정여림상증상군적상관성.방법 대22위수발억욱환자화26위성별、년령상필배적건강대조,진행3.0T자공진소묘.이수교육년한위협변량,비교량조수시뇌구저빈진폭(ALFF)치,장유통계학차이적뇌구ALFF균치여림상증상군엄중정도진행상관분석.결과 환자조교대조조우액중회(9,45,-6;K=18)화쌍측사상회(-34,-19,-12;K=37화30,-33,-18;K=31)ALFF치증고,좌설전협(0,-72,42; K=19)ALFF강저(P＜0.05,Alphasim교정).우액중회、우사상회화좌설전협ALFF치,분별여체질량인자분、조체인자분화수면장애인자분정부상관(r=-0.494,P=0.019;r=-0.486,P=0.022화r=-0.484,P=0.023),기여상관성무통계학의의(P＞0.05).결론 수발억욱증환자특정증상군적엄중정도여정식상태하뇌국부신경원활동강도이상유관.
Objective To explore the relationship between energy feature of the spontaneous neural activity and separate symptom clusters in first-episode depression.Methods 22 first-episode depression patients and 26 age-,gender-matched healthy controls were scanned with 3.0 T MRI Scanner.The t-test was employed to compare the difference of amplitude of low frequency fluctuation (ALFF) between the two groups,and the correlation analyses were conducted between ALFF of brain regions with significant difference and the severity of depressive symptoms clusters.Results Compared with healthy group,the depression group showed significantly increased ALFF in the right middle frontal gyrus (9,45,-6; K =18) and the bilateral fusiform gyrus (-34,-19,-12; K =37 and 30,-33,-18 ; K =31,respectively),and decreased ALFF in the left precuneus (0,-72,42; K =19) (P＜0.05,corrected by Alphasim).The ALFF of the the right middle frontal gyrus,the right fusiform gyrus,and the left precuneus were negative correlated with the scores of weight factor,retardation factor and sleep disturbance factor (r=-0.494,P=0.019; r=-0.486,P=0.022 and r=-0.484,P=0.023,respectively).Conclusion Abnormal energy feature of the spontaneous neural activity may be associated with severity of specific depressive symptoms clusters in first-episode depression patients during resting-state.