CAJ | 학술논문

目的探讨抑郁症患者与正常人脑结构网络节点连接强度、聚类系数和局部效率属性的异同,分析抑郁症患者大脑各区域的局部连接模式和局部信息传递效率改变及其与疾病严重程度的相关性.方法对24例抑郁症患者、25名正常人进行弥散张量成像扫描(Diffusion Tensor Imaging,DTI),利用解剖学自动标记模板(AAL)将整个大脑划分为90个区域,采用FACT(fiber assignment by continuous tracking)方法进行纤维跟踪,结合基于图论的复杂网络方法构建脑结构网络,并对所得抑郁症患者与正常人脑结构网络的节点局部属性值进行双样本t检验.结果 (1)抑郁症组局部效率属性值(左侧额中回眶部:0.64±0.30、左侧海马:0.57±0.07、右侧海马旁回:0.50±0.15)较对照组(0.88±0.10、0.64±0.06、0.66±0.13,P=0.00098、0.00039、0.00017,通过FDR校正)显著下降;(2)抑郁症组聚类系数属性值(左侧额中回眶部:0.14±0.07)较对照组(0.22±0.06,P=0.000030,通过FDR校正)显著下降;(3)抑郁症组左侧额中回眶部局部效率属性值与HAMD-17总分呈显著负相关(r=-0.48,P=0.02).结论抑郁症患者大脑额叶相关脑区连接的集团化程度及局部信息传递效率均发生下降,海马结构的局部信息传递效率也发生下降;其中,额叶相关脑区的局部信息传递效率下降导致疾病严重程度增加.
목적 탐토억욱증환자여정상인뇌결구망락절점련접강도、취류계수화국부효솔속성적이동,분석억욱증환자대뇌각구역적국부련접모식화국부신식전체효솔개변급기여질병엄중정도적상관성.방법 대24례억욱증환자、25명정상인진행미산장량성상소묘(Diffusion Tensor Imaging,DTI),이용해부학자동표기모판(AAL)장정개대뇌화분위90개구역,채용FACT(fiber assignment by continuous tracking)방법진행섬유근종,결합기우도론적복잡망락방법구건뇌결구망락,병대소득억욱증환자여정상인뇌결구망락적절점국부속성치진행쌍양본t검험.결과 (1)억욱증조국부효솔속성치(좌측액중회광부:0.64±0.30、좌측해마:0.57±0.07、우측해마방회:0.50±0.15)교대조조(0.88±0.10、0.64±0.06、0.66±0.13,P=0.00098、0.00039、0.00017,통과FDR교정)현저하강;(2)억욱증조취류계수속성치(좌측액중회광부:0.14±0.07)교대조조(0.22±0.06,P=0.000030,통과FDR교정)현저하강;(3)억욱증조좌측액중회광부국부효솔속성치여HAMD-17총분정현저부상관(r=-0.48,P=0.02).결론 억욱증환자대뇌액협상관뇌구련접적집단화정도급국부신식전체효솔균발생하강,해마결구적국부신식전체효솔야발생하강;기중,액협상관뇌구적국부신식전체효솔하강도치질병엄중정도증가.
Objective To explore the differences of the connectivity strength,the clustering coefficient and the local efficiency of the nodes in the brain structural networks in the depression and healthy subjects and then analyze the mode of the local connections of the brain regions and their local efficiency of the transmission of information and their relationship with the severity of the disease in the depression.Methods The Diffusion Tensor Imaging data were obtained from 24 depression patients and 25 healthy controls.The whole cerebral cortex was parcellated into 90 regions by the anatomical label map.Tractography was performed in the whole cerebral cortex of each subject to reconstruct white matter tracts of the brain using the fiber assignment by continuous tracking (FACT) algorithm.And then the brain structural networks were constructed using the complex network theory.The local topological properties of the brain structural networks of the depression and healthy were examined by two sample t-test.Results The local efficiency of the nodes of the networks in depression decreased significantly (the left middle frontal gyrus (orbital part):0.64±0.30,the left hippocampus:0.57±0.07,the right parahippocampal gyrus:0.50±0.15) compared with the healthy (0.88±0.10,0.64±0.06,0.66±0.13 respectively,P=0.00098,0.00039,0.00017,survived critical FDR threshold for multiple comparisons) ; and the clustering coefficient of the nodes of the networks in depression (the left middle frontal gyrus (orbital part):0.14±0.07) decreased significantly when compared with the healthy (0.22±0.06,P=0.000030,survived critical FDR threshold for multiple comparisons).Significant negative correlation was found between the local efficiency of the left middle frontal gyrus (orbital part) and the total scores of HAMD-17 in the depression (r=-0.48,P=0.02).Conclusion The degree of the localization and the local efficiency of the information transmission of the frontal lobe are decreased.The local efficiency in the information transmission in the hippocampal is also decreased.And the local efficiency of the frontal lobe is negatively related with the severity of the disease in the depression.