中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2014年
10期
893-896
,共4页
陈熊鹰%吉峰%翟金国%陈敏%张秋梅%高立%孙晓晨%刘真%张志芳%于萍%李君
陳熊鷹%吉峰%翟金國%陳敏%張鞦梅%高立%孫曉晨%劉真%張誌芳%于萍%李君
진웅응%길봉%적금국%진민%장추매%고립%손효신%류진%장지방%우평%리군
ZNF804A基因%rs7597593多态性%精神分裂症%认知功能
ZNF804A基因%rs7597593多態性%精神分裂癥%認知功能
ZNF804A기인%rs7597593다태성%정신분렬증%인지공능
ZNF804A gene%rs7597593 polymorphism%Schizophrenia%Cognitive function
目的 探究ZNF804A基因rs7597593多态位点与精神分裂症的关系,并进一步考察rs7597593多态性对精神分裂症认知功能的影响.方法 采用病例对照研究方法,以DSM-Ⅳ为诊断标准,纳入精神分裂症患者767例和健康对照组690例.使用RFLP实验方法对ZNF804A基因的rs7597593多态位点进行基因分型;使用1-back任务错误率为认知功能评定指标;使用SPSS 19.0软件进行统计分析.结果 rs7597593多态性与精神分裂症在基因型频率及等位基因频率上均差异无统计学意义(x2值分别为1.519和1.263;P值分别为0.468和0.261);但随智力水平的提高,其与精神分裂症关联性变强.当智商≥110时,基因型和等位基因频率在精神分裂症组和对照组间均差异有统计学意义(x2值分别为9.411和6.529;P值分别为0.009和0.011);且当智商≥110时,携带风险等位基因T的个体(0.197±0.171)比非携带者(0.167±0.165)在1-back任务上错误率更高(F=6.854,P=0.009).结论 ZNF804A基因的rs7597593多态性的风险人群可能是认知能力保持相对完整的精神分裂症;在此风险人群中,风险等位基因T可能导致认知功能下降.
目的 探究ZNF804A基因rs7597593多態位點與精神分裂癥的關繫,併進一步攷察rs7597593多態性對精神分裂癥認知功能的影響.方法 採用病例對照研究方法,以DSM-Ⅳ為診斷標準,納入精神分裂癥患者767例和健康對照組690例.使用RFLP實驗方法對ZNF804A基因的rs7597593多態位點進行基因分型;使用1-back任務錯誤率為認知功能評定指標;使用SPSS 19.0軟件進行統計分析.結果 rs7597593多態性與精神分裂癥在基因型頻率及等位基因頻率上均差異無統計學意義(x2值分彆為1.519和1.263;P值分彆為0.468和0.261);但隨智力水平的提高,其與精神分裂癥關聯性變彊.噹智商≥110時,基因型和等位基因頻率在精神分裂癥組和對照組間均差異有統計學意義(x2值分彆為9.411和6.529;P值分彆為0.009和0.011);且噹智商≥110時,攜帶風險等位基因T的箇體(0.197±0.171)比非攜帶者(0.167±0.165)在1-back任務上錯誤率更高(F=6.854,P=0.009).結論 ZNF804A基因的rs7597593多態性的風險人群可能是認知能力保持相對完整的精神分裂癥;在此風險人群中,風險等位基因T可能導緻認知功能下降.
목적 탐구ZNF804A기인rs7597593다태위점여정신분렬증적관계,병진일보고찰rs7597593다태성대정신분렬증인지공능적영향.방법 채용병례대조연구방법,이DSM-Ⅳ위진단표준,납입정신분렬증환자767례화건강대조조690례.사용RFLP실험방법대ZNF804A기인적rs7597593다태위점진행기인분형;사용1-back임무착오솔위인지공능평정지표;사용SPSS 19.0연건진행통계분석.결과 rs7597593다태성여정신분렬증재기인형빈솔급등위기인빈솔상균차이무통계학의의(x2치분별위1.519화1.263;P치분별위0.468화0.261);단수지력수평적제고,기여정신분렬증관련성변강.당지상≥110시,기인형화등위기인빈솔재정신분렬증조화대조조간균차이유통계학의의(x2치분별위9.411화6.529;P치분별위0.009화0.011);차당지상≥110시,휴대풍험등위기인T적개체(0.197±0.171)비비휴대자(0.167±0.165)재1-back임무상착오솔경고(F=6.854,P=0.009).결론 ZNF804A기인적rs7597593다태성적풍험인군가능시인지능력보지상대완정적정신분렬증;재차풍험인군중,풍험등위기인T가능도치인지공능하강.
Objective To assess the association between rs7597593 polymorphism of ZNF804A gene and schizophrenia,and to assess the relationship between rs7597593 polymorphism and working memory.Methods Schizophrenia patients and healthy controls were diagnosed in accordance with Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (DSM-Ⅳ) ; 767 schizophrenia patients and 690 healthy controls were involved.Restriction fragment length polymorphism (RFLP) was carried out to genotype rs7597593 polymorphism.The cognitive function of working memory was assessed by the N-back task.Statistical analyses were carried out with SPSS19.0 software.Results The study found no significantly different genotype frequencies (x2=1.519,P=0.468) and allele frequencies(x2=1.263,P=0.261) of rs7597593 polymorphism between schizophrenia patients and healthy controls,however in the subgroup of higher IQ (IQ ≥ 110),there were significant different distributions of both genotype and allele (x2 =9.411 and 6.529; P=0.009 and 0.011 respectively).It was also found in this subgroup that risk T allele was associated with more error at 1-back task (F=6.854,P=0.009).Conclusion These results indicated that rs7597593 polymorphism was associated with individuals having spared cognitive function; carriers of T allele had worse cognitive function,which maybe a pathway that it contributes to schizophrenia.
