中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2012年
z1期
11-13
,共3页
张妍%程雯%徐婷%陈淑雯
張妍%程雯%徐婷%陳淑雯
장연%정문%서정%진숙문
2型糖尿病%颈动脉内膜厚度%生存质量
2型糖尿病%頸動脈內膜厚度%生存質量
2형당뇨병%경동맥내막후도%생존질량
Diabetes mellitus,type 2%Carotid intima media thickness%Quality of life
目的 观察2型糖尿病患者亚临床动脉粥样硬化与生存质量的相关性,探讨大血管病变对糖尿病生存质量的影响.方法 选取2型糖尿病患者136例,采用高分辨率彩色多普勒超声检查双侧颈总动脉内膜厚度(IMT),根据颈动脉超声检查结果,分为亚临床动脉粥样硬化组(AS组)51例和对照组(CON组)85例,采用糖尿病患者特异性生活质量量表(DSQL)对两组患者进行生存质量测定.检测两组患者空腹血糖(FBG)、空腹胰岛素(FINS)、糖化血红蛋白(HbA1c),超敏C反应蛋白(hsCRP)；分别计算体重指数(BMI)、胰岛素抵抗指数(HOMA-IR).结果 AS组与CON组比较生存质量总分(DSQL)、纬度因子分明显升高,其差异有统计学意义(P＜0.01).AS组与CON组比较BMI、HbA1c、HOMA-IR、hsCRP升高,差异均有统计学意义(P＜0.01或P＜0.05).以IMT、BMI、HbA1c、hsCRP、HOMA-IR为自变量,对DSQL进行相关分析,DSQL与IMT、BMI、HbA1c、hsCRP、HOMA-IR呈正相关(r=0.28～0.63,P＜0.01或P＜0.05).结论 大血管病变可导致糖尿病患者生存质量下降,与血糖控制不良、胰岛功能减退、促进中心型肥胖形成、血管内皮炎症反应等因素相关,应加强糖尿病患者颈动脉硬化的治疗,对合并大血管病变患者重视健康教育、心理指导以期提高生存质量.
目的 觀察2型糖尿病患者亞臨床動脈粥樣硬化與生存質量的相關性,探討大血管病變對糖尿病生存質量的影響.方法 選取2型糖尿病患者136例,採用高分辨率綵色多普勒超聲檢查雙側頸總動脈內膜厚度(IMT),根據頸動脈超聲檢查結果,分為亞臨床動脈粥樣硬化組(AS組)51例和對照組(CON組)85例,採用糖尿病患者特異性生活質量量錶(DSQL)對兩組患者進行生存質量測定.檢測兩組患者空腹血糖(FBG)、空腹胰島素(FINS)、糖化血紅蛋白(HbA1c),超敏C反應蛋白(hsCRP)；分彆計算體重指數(BMI)、胰島素牴抗指數(HOMA-IR).結果 AS組與CON組比較生存質量總分(DSQL)、緯度因子分明顯升高,其差異有統計學意義(P＜0.01).AS組與CON組比較BMI、HbA1c、HOMA-IR、hsCRP升高,差異均有統計學意義(P＜0.01或P＜0.05).以IMT、BMI、HbA1c、hsCRP、HOMA-IR為自變量,對DSQL進行相關分析,DSQL與IMT、BMI、HbA1c、hsCRP、HOMA-IR呈正相關(r=0.28～0.63,P＜0.01或P＜0.05).結論 大血管病變可導緻糖尿病患者生存質量下降,與血糖控製不良、胰島功能減退、促進中心型肥胖形成、血管內皮炎癥反應等因素相關,應加彊糖尿病患者頸動脈硬化的治療,對閤併大血管病變患者重視健康教育、心理指導以期提高生存質量.
목적 관찰2형당뇨병환자아림상동맥죽양경화여생존질량적상관성,탐토대혈관병변대당뇨병생존질량적영향.방법 선취2형당뇨병환자136례,채용고분변솔채색다보륵초성검사쌍측경총동맥내막후도(IMT),근거경동맥초성검사결과,분위아림상동맥죽양경화조(AS조)51례화대조조(CON조)85례,채용당뇨병환자특이성생활질량량표(DSQL)대량조환자진행생존질량측정.검측량조환자공복혈당(FBG)、공복이도소(FINS)、당화혈홍단백(HbA1c),초민C반응단백(hsCRP)；분별계산체중지수(BMI)、이도소저항지수(HOMA-IR).결과 AS조여CON조비교생존질량총분(DSQL)、위도인자분명현승고,기차이유통계학의의(P＜0.01).AS조여CON조비교BMI、HbA1c、HOMA-IR、hsCRP승고,차이균유통계학의의(P＜0.01혹P＜0.05).이IMT、BMI、HbA1c、hsCRP、HOMA-IR위자변량,대DSQL진행상관분석,DSQL여IMT、BMI、HbA1c、hsCRP、HOMA-IR정정상관(r=0.28～0.63,P＜0.01혹P＜0.05).결론 대혈관병변가도치당뇨병환자생존질량하강,여혈당공제불량、이도공능감퇴、촉진중심형비반형성、혈관내피염증반응등인소상관,응가강당뇨병환자경동맥경화적치료,대합병대혈관병변환자중시건강교육、심리지도이기제고생존질량.
Objective To observe the changes of the quality of life in type 2 diabetes accompanying subclinical atherosclerosis and explore the effect of diabetic macrovascular complications in the quality of life.Methods One hundred and thiry-six type 2 diabetes were measured carotid intima media thickness (IMT) and then divided into AS group(n =51) and CON group(n =85).Two groups were examined with Special of Quality of Life for Diabetes Mellitus (DSQL).Plasma glucose,plasma insulin,glycosylated hemoglobin(HbA1c),high sensitivity C-Reactive Protein (hs-CRP) as well as insulin resistance index (HOMA-IR) and body mass index (BMI) were observed.Results The scores of DSQL and all domains had obvious difference between AS group and control group(P ＜0.05 orP ＜0.01) ;Relative to the control group the AS group was significantly increased BMI,HbA1c levels,hsCRP levels.The DSQL was associated with IMT,BMI,HbA1c,hsCRP,HOMA-IR.Conclusion The diabetic macrovascular compliations might result in impaired quality of life,which is associated with hyperglycemia,insulin resistance,inflammation,and central obesity.Psychotherapy and health education are very important for the improvement the DSQL in type 2 diabetic accompanying subclinical atherosclerosis.
