CAJ | 학술논문

目的探讨高血尿酸水平(HUA)对高血压患者炎症反应和内皮素-1(ET-1)水平的影响以及苯溴马隆治疗的效果.方法选取本院门诊和住院初诊高血压患者90例,其中合并HUA患者60例,正常血尿酸组患者30例.所有高血压合并HUA患者均给予基础降压药物,并选择30例患者同时给予苯溴马隆片50 mg,每晨空腹顿服.比较高血压合并HUA患者和正常血尿酸组患者以及高血压合并HUA患者基础降压加苯溴马隆治疗与单纯基础降压治疗8周后各项炎症指标和ET-1含量变化.结果高血压合并HUA患者血ET-1、白细胞介素-1(IL-1)以及超敏C反应蛋白(hsCRP)浓度显著高于血尿酸正常组,并与血尿酸浓度成正相关[(86.6±4.8)pg/ml vs (82.4±6.9)pg/ml;(47.6 ±6.2)mg/L vs (19.1±4.1)mg/L; (3.4±0.8)mg/L vs (2.9±1.1) mg/L,r=0.81、0.74、0.83,P均＜0.05].而苯溴马隆可有效降低高血压合并HUA患者血ET-1、IL-1和hsCRP[(49.8±5.0) pg/ml vs (87.5±5.9)pg/ml;(17.6±8.8) mg/L vs (48.2±7.0)mg/L;(1.7±0.7)mg/L vs (3.5±0.9) mg/L,P均＜0.05].结论 HUA可增加高血压患者炎症反应和ET-1水平,而苯溴马隆治疗有效减轻患者炎症反应和降低血ET-1水平,降低高血压合并HUA患者血尿酸水平可能具有延缓高血压患者动脉粥样硬化进程的作用.
목적 탐토고혈뇨산수평(HUA)대고혈압환자염증반응화내피소-1(ET-1)수평적영향이급분추마륭치료적효과.방법 선취본원문진화주원초진고혈압환자90례,기중합병HUA환자60례,정상혈뇨산조환자30례.소유고혈압합병HUA환자균급여기출강압약물,병선택30례환자동시급여분추마륭편50 mg,매신공복돈복.비교고혈압합병HUA환자화정상혈뇨산조환자이급고혈압합병HUA환자기출강압가분추마륭치료여단순기출강압치료8주후각항염증지표화ET-1함량변화.결과 고혈압합병HUA환자혈ET-1、백세포개소-1(IL-1)이급초민C반응단백(hsCRP)농도현저고우혈뇨산정상조,병여혈뇨산농도성정상관[(86.6±4.8)pg/ml vs (82.4±6.9)pg/ml;(47.6 ±6.2)mg/L vs (19.1±4.1)mg/L; (3.4±0.8)mg/L vs (2.9±1.1) mg/L,r=0.81、0.74、0.83,P균＜0.05].이분추마륭가유효강저고혈압합병HUA환자혈ET-1、IL-1화hsCRP[(49.8±5.0) pg/ml vs (87.5±5.9)pg/ml;(17.6±8.8) mg/L vs (48.2±7.0)mg/L;(1.7±0.7)mg/L vs (3.5±0.9) mg/L,P균＜0.05].결론 HUA가증가고혈압환자염증반응화ET-1수평,이분추마륭치료유효감경환자염증반응화강저혈ET-1수평,강저고혈압합병HUA환자혈뇨산수평가능구유연완고혈압환자동맥죽양경화진정적작용.
Objective To investigate the effect of hyperuricemia(HUA) on inflammation and endothelin-1 (ET-1) production and treatment of Benzbnomanone in hypertensive patients.Methods 90 initial hypertensive patients were enrolled from the inpatient division and clinic of our hospital,60 patients of them were identified HUA,and 30 patients were normal in uric acid as control.All these hypertensive patients with HUA were treated with basic anti-hypertensive drugs,of them 30 patients were additionally treated with Benzbromarone table 50mg for 8 weeks.The levels of inflammation indices and ET-1 were compared between these hypertensive patients with HUA and hypertensive patients with normal serum uric acid,also hypertensive patients with HUA treated with or without Benzbromarone for 8 weeks.Results Compared with the hypertensive patients with normal serum uric acid,levels of ET-1,interleukin-1 (IL-1) and high-sensitive C reactive protein (hsCRP) were higher in the hypertensive patients with HUA.Also,the levels of these indices were positively correlated with the level of serum uric acid [(86.6 ± 4.8) pg/ml vs (82.4 ±6.9)pg/ml; (47.6 ±6.2)mg/L vs (19.1 ±4.1) mg/L; (3.4 ±0.8)mg/L vs (2.9 ± 1.1)mg/L,r =0.81,0.74,0.83,all P ＜ 0.05].Benzbromarone could effectively decrease the levels of ET-1,IL-1and hsCRP in the hypertensive patients with HUA [(49.8 ± 5.0) pg/ml vs (87.5 ± 5.9) pg/ml ; (17.6 ±8.8) mg/L vs (48.2 ± 7.0) mg/L; (1.7 ± 0.7) mg/L vs (3.5 ± 0.9) mg/L,all P ＜ 0.05].Conclusions HUA could increase the levels of inflammation and ET-1,while Benzbromarone effectivelv decreased these changes.Decreasing the level of serum uric acid would retard the process of atherosclerosis in the hypertensive patients with HUA.