中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2013年
2期
197-199
,共3页
马赟%肖立志%龚颖萍%崔毅
馬赟%肖立誌%龔穎萍%崔毅
마빈%초립지%공영평%최의
抗原,肿瘤相关,碳水化合物/血液%卵巢肿瘤/诊断%卵巢肿瘤/放射摄影术%体层摄影术,X线计算机
抗原,腫瘤相關,碳水化閤物/血液%卵巢腫瘤/診斷%卵巢腫瘤/放射攝影術%體層攝影術,X線計算機
항원,종류상관,탄수화합물/혈액%란소종류/진단%란소종류/방사섭영술%체층섭영술,X선계산궤
Antigens,tumor-associated,carbohydrate/blood%Ovarian neoplasms/diagnosis%Ovarian neoplasms/radiography%Tomography,X-ray computed
目的 探讨CT联合血清CA125和人附睾蛋白4(HE4)对卵巢上皮性癌的诊断价值.方法 对本院52例卵巢上皮癌(卵巢癌组)、47例卵巢上皮性良性肿瘤(对照组)、40例体检健康妇女(健康组)测定血清CA125、HE4水平,术前1周内对卵巢癌组和对照组患者行CT检查,分析CT联合血清CA125和HE4对卵巢上皮性癌的诊断价值.结果 卵巢癌组CA125、HE4水平[(264.37±138.46) KU/L,(280.38±135.14) pmol/L]高于对照组[(52.51±5.29)KU/L,(40.52±10.34)pmol/L]和健康组[(10.69±6.15) KU/L,(37.24±9.84) pmol/L],其差异均有统计学意义(P＜0.01).血清CA125水平对照组与健康组比较差异有统计学意义(P＜0.05)；血清HE4水平对照组高于健康组,但差异无统计学意义(P＞0.05).CA125、HF4和CT三种方法在诊断卵巢癌的灵敏度(65.4％,80.8％,75.0％)、特异度(74.5％,85.1％,76.6％)和准确度(69.7％,82.8％,75.8％)比较差异均无统计学意义(P＞0.05).CT与CA125、HF4联合诊断能提高卵巢癌的诊断敏感度(92.3％)、特异度(93.6％)及准确度(94.8％),与单项方法比较,差异有统计学意义(x2=7.461,18.711,P＜0.01),与其中两项联合比较,差异无统计学意义(P＞0.05).结论 卵巢上皮性癌患者血清CA125、HE4水平显著升高,联合卵巢上皮性癌CT影像学改变能提高其诊断的敏感度、特异度、准确度,上述三项联合检查对良恶卵巢上皮性肿瘤具有鉴别诊断意义.
目的 探討CT聯閤血清CA125和人附睪蛋白4(HE4)對卵巢上皮性癌的診斷價值.方法 對本院52例卵巢上皮癌(卵巢癌組)、47例卵巢上皮性良性腫瘤(對照組)、40例體檢健康婦女(健康組)測定血清CA125、HE4水平,術前1週內對卵巢癌組和對照組患者行CT檢查,分析CT聯閤血清CA125和HE4對卵巢上皮性癌的診斷價值.結果 卵巢癌組CA125、HE4水平[(264.37±138.46) KU/L,(280.38±135.14) pmol/L]高于對照組[(52.51±5.29)KU/L,(40.52±10.34)pmol/L]和健康組[(10.69±6.15) KU/L,(37.24±9.84) pmol/L],其差異均有統計學意義(P＜0.01).血清CA125水平對照組與健康組比較差異有統計學意義(P＜0.05)；血清HE4水平對照組高于健康組,但差異無統計學意義(P＞0.05).CA125、HF4和CT三種方法在診斷卵巢癌的靈敏度(65.4％,80.8％,75.0％)、特異度(74.5％,85.1％,76.6％)和準確度(69.7％,82.8％,75.8％)比較差異均無統計學意義(P＞0.05).CT與CA125、HF4聯閤診斷能提高卵巢癌的診斷敏感度(92.3％)、特異度(93.6％)及準確度(94.8％),與單項方法比較,差異有統計學意義(x2=7.461,18.711,P＜0.01),與其中兩項聯閤比較,差異無統計學意義(P＞0.05).結論 卵巢上皮性癌患者血清CA125、HE4水平顯著升高,聯閤卵巢上皮性癌CT影像學改變能提高其診斷的敏感度、特異度、準確度,上述三項聯閤檢查對良噁卵巢上皮性腫瘤具有鑒彆診斷意義.
목적 탐토CT연합혈청CA125화인부고단백4(HE4)대란소상피성암적진단개치.방법 대본원52례란소상피암(란소암조)、47례란소상피성량성종류(대조조)、40례체검건강부녀(건강조)측정혈청CA125、HE4수평,술전1주내대란소암조화대조조환자행CT검사,분석CT연합혈청CA125화HE4대란소상피성암적진단개치.결과 란소암조CA125、HE4수평[(264.37±138.46) KU/L,(280.38±135.14) pmol/L]고우대조조[(52.51±5.29)KU/L,(40.52±10.34)pmol/L]화건강조[(10.69±6.15) KU/L,(37.24±9.84) pmol/L],기차이균유통계학의의(P＜0.01).혈청CA125수평대조조여건강조비교차이유통계학의의(P＜0.05)；혈청HE4수평대조조고우건강조,단차이무통계학의의(P＞0.05).CA125、HF4화CT삼충방법재진단란소암적령민도(65.4％,80.8％,75.0％)、특이도(74.5％,85.1％,76.6％)화준학도(69.7％,82.8％,75.8％)비교차이균무통계학의의(P＞0.05).CT여CA125、HF4연합진단능제고란소암적진단민감도(92.3％)、특이도(93.6％)급준학도(94.8％),여단항방법비교,차이유통계학의의(x2=7.461,18.711,P＜0.01),여기중량항연합비교,차이무통계학의의(P＞0.05).결론 란소상피성암환자혈청CA125、HE4수평현저승고,연합란소상피성암CT영상학개변능제고기진단적민감도、특이도、준학도,상술삼항연합검사대량악란소상피성종류구유감별진단의의.
Objective To study the diagnostic value of CT combined CA125 and HE4 in differentiating the ovarian cancer from the benign.Methods A case-control study included 52 ovarian cancer patients,47 patients with benign ovarian tumors,and 40 healthy control subjects.Preoperative serum levels of HE4 and CA125 were measured and CT was performed.Results The serum levels of CA125 and HE4 in the ovarian cancer groups [(264.37 ± 138.46) KU/L,(280.38 ± 135.14)pmol/L] were significantly high-er than that in the benign ovarian neoplasm group [(52.51 ±5.29) KU/L,(40.52 ± 10.34) pmol/L] and healthy control group [(10.69 ±6.15)KU/L,(37.24 ±9.84) pmol/L] (P ＜0.01).The serum levels of CA125 showed statistically significant difference between the benign ovarian neoplasm groups and healthy control groups (P ＜ 0.05).The serum levels of HE4 did not show statistically significant difference between the benign ovarian neoplasm groups and healthy control groups (P ＞ 0.05).The diagnostic sensitivity (65.4％,80.8％,75.0％),specificity (74.5％,85.1％,76.6％),and accuracy (69.7％,82.8％,75.8％) of each CA125,HE4,CT method for ovarian cancer did not show statistically significant difference (P ＞0.05).The diagnostic sensitivity (92.3％),specificity (93.6％) and accuracy (94.8％) of combination of CA125 and HE4 and CT were significantly higher and showed statistically significant difference compared with one method (x2 =7.461 18.711,P ＜ 0.01),but no significant difference compared with any two methods (P ＞ 0.05).Conclusions The serum levels of HE4 and CA125 in the ovarian cancer group were significantly higher,and CT in combination with those two serum indices improved the diagnostic sensitivity,specificity,and accuracy of ovarian cancer.
