中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2013年
7期
890-894
,共5页
心力衰竭%慢性病%红细胞指数%每搏输出量%心室功能,左%C反应蛋白质%尿酸
心力衰竭%慢性病%紅細胞指數%每搏輸齣量%心室功能,左%C反應蛋白質%尿痠
심력쇠갈%만성병%홍세포지수%매박수출량%심실공능,좌%C반응단백질%뇨산
Heart failure%Chronic disease%Erythrocyte indices%Stroke volume%Ventricular function,left%C-reactive protein%Uric acid
目的 通过对慢性心力衰竭患者红细胞分布宽度(RDW)与左室射血分数(LVEF)、左室舒张末内径(LVEDD)、高敏C反应蛋白(hs-CRP)、尿酸(UA)的相关性研究,探讨RDW水平与慢性心力衰竭患者心功能变化的关系及其可能的机制.方法 选择280例患者作为研究对象,每位患者均接受心脏彩色多普勒超声、12导同步体表心电图、血生化及血常规检测.根据LVEF值、LVEDD值及RDW值不同进行分组,各组之间进行相关指标比较.结果 根据患者LVEF值分组,从组A至组D,随着LVEF值逐渐减低,RDW值逐渐增加[(13.48±0.85)％、(14.10±1.46)％、(14.59±1.59)％、(14.75±1.42)％,F=12.698,P＜0.01],各组间两两比较差异具有统计学意义(P＜0.01)；RDW水平与LVEF值呈负相关(r=-0.538,P＜0.01).根据患者LVEDD值分组,从组a至组d,随着LVEDD值逐渐增大,RDW值逐渐增加[(13.53±0.91)％,(14.12±1.42)％,(14.60±1.68)％,(14.76±1.39)％,F=12.276,P＜0.01]；各组间两两比较差异具有统计学意义(P＜0.01)；慢性心力衰竭患者RDW水平与LVEDD值呈正相关(r=0.343,P＜0.01).在慢性心力衰竭患者中,RDW与hs-CRP、尿酸值经对数转换(LgUA)均呈正相关(r=0.486、0.513,P ＜0.05).结论 RDW水平可反映慢性心力衰竭患者心功能的变化,随着LVEF值降低,LVEDD值增大,RDW值逐渐升高；RDW与hs-CRP、LgUA有较强的相关性,提示慢性心力衰竭患者RDW水平升高可能与炎性反应及氧化应激有关.
目的 通過對慢性心力衰竭患者紅細胞分佈寬度(RDW)與左室射血分數(LVEF)、左室舒張末內徑(LVEDD)、高敏C反應蛋白(hs-CRP)、尿痠(UA)的相關性研究,探討RDW水平與慢性心力衰竭患者心功能變化的關繫及其可能的機製.方法 選擇280例患者作為研究對象,每位患者均接受心髒綵色多普勒超聲、12導同步體錶心電圖、血生化及血常規檢測.根據LVEF值、LVEDD值及RDW值不同進行分組,各組之間進行相關指標比較.結果 根據患者LVEF值分組,從組A至組D,隨著LVEF值逐漸減低,RDW值逐漸增加[(13.48±0.85)％、(14.10±1.46)％、(14.59±1.59)％、(14.75±1.42)％,F=12.698,P＜0.01],各組間兩兩比較差異具有統計學意義(P＜0.01)；RDW水平與LVEF值呈負相關(r=-0.538,P＜0.01).根據患者LVEDD值分組,從組a至組d,隨著LVEDD值逐漸增大,RDW值逐漸增加[(13.53±0.91)％,(14.12±1.42)％,(14.60±1.68)％,(14.76±1.39)％,F=12.276,P＜0.01]；各組間兩兩比較差異具有統計學意義(P＜0.01)；慢性心力衰竭患者RDW水平與LVEDD值呈正相關(r=0.343,P＜0.01).在慢性心力衰竭患者中,RDW與hs-CRP、尿痠值經對數轉換(LgUA)均呈正相關(r=0.486、0.513,P ＜0.05).結論 RDW水平可反映慢性心力衰竭患者心功能的變化,隨著LVEF值降低,LVEDD值增大,RDW值逐漸升高；RDW與hs-CRP、LgUA有較彊的相關性,提示慢性心力衰竭患者RDW水平升高可能與炎性反應及氧化應激有關.
목적 통과대만성심력쇠갈환자홍세포분포관도(RDW)여좌실사혈분수(LVEF)、좌실서장말내경(LVEDD)、고민C반응단백(hs-CRP)、뇨산(UA)적상관성연구,탐토RDW수평여만성심력쇠갈환자심공능변화적관계급기가능적궤제.방법 선택280례환자작위연구대상,매위환자균접수심장채색다보륵초성、12도동보체표심전도、혈생화급혈상규검측.근거LVEF치、LVEDD치급RDW치불동진행분조,각조지간진행상관지표비교.결과 근거환자LVEF치분조,종조A지조D,수착LVEF치축점감저,RDW치축점증가[(13.48±0.85)％、(14.10±1.46)％、(14.59±1.59)％、(14.75±1.42)％,F=12.698,P＜0.01],각조간량량비교차이구유통계학의의(P＜0.01)；RDW수평여LVEF치정부상관(r=-0.538,P＜0.01).근거환자LVEDD치분조,종조a지조d,수착LVEDD치축점증대,RDW치축점증가[(13.53±0.91)％,(14.12±1.42)％,(14.60±1.68)％,(14.76±1.39)％,F=12.276,P＜0.01]；각조간량량비교차이구유통계학의의(P＜0.01)；만성심력쇠갈환자RDW수평여LVEDD치정정상관(r=0.343,P＜0.01).재만성심력쇠갈환자중,RDW여hs-CRP、뇨산치경대수전환(LgUA)균정정상관(r=0.486、0.513,P ＜0.05).결론 RDW수평가반영만성심력쇠갈환자심공능적변화,수착LVEF치강저,LVEDD치증대,RDW치축점승고；RDW여hs-CRP、LgUA유교강적상관성,제시만성심력쇠갈환자RDW수평승고가능여염성반응급양화응격유관.
Objective To investigate the association between red blood cell distribution width (RDW) level and the change of cardiac function in patients with chronic heart failure (CHF) and explore its possible mechanism by studying the correlation between RDW and left ventricular ejection fraction (LVEF),left ventricular end-diastolic dimension (LVEDD),and high-sensitivity C-reactive protein (hsCRP),and uric acid(UA) in patients with chronic heart failure.Methods Two hundred and eighty patients were included in our study.Each patient received the examinations of echocardiography,electrocar diogram (ECG),blood routine,and blood biochemistry.According to the different LVEF,LVEDD and RDW,the patients were divided into groups A,B,C,and D,respectively.The groups were compared with each other.Results According to the different LVEF,from group A to group D,with a progressive decrease in LVEF,RDW level were increased gradually [(13.48 ± 0.85) ％,(14.10 ± 1.46) ％,(14.59 ±1.59)％,(14.75±1.42)％,F =12.698,P ＜0.01].There was significant difference among the four groups (P ＜0.01).RDW level correlated inversely with LVEF(r =-0.538,P ＜0.01).According to the different LVEDD,from group A to group D,with a progressive increase in LVEDD,RDW level increased gradually [(13.53 ±0.91)％,(14.12±1.42)％,(14.60±1.68)％,(14.76±1.39)％,F =12.276,P ＜0.01].There was significant difference among the four groups (P ＜0.01).RDW level correlated positively with LVEDD (r =0.343,P ＜0.01).In chronic heart failure patients,there were significant linear correlation between RDW and hs-CRP,LgUA (r =0.486,0.513,P ＜0.05).Conclusions RDW correlated with the change of cardiac function in patients with chronic heart failure.With a progressive decrease in LVEF and a progressive increase in LVEDD,RDW level increased gradually.RDW had a strong correlation with hs-CRP,LgUA.This indicates that RDW level increase may be related to the inflammation and oxidative reaction in patients with chronic heart failure.
