CAJ | 학술논문

目的探讨慢性阻塞性肺疾病(COPD)患者全身炎症反应与BODE指数的关系及意义.方法采集60例稳定期COPD患者BODE评分,并检测其血清肿瘤坏死因子α(TNF-α)、白细胞介素8(IL-8)及C反应蛋白(CRP).对BODE指数与炎性因子的相关性进行分析.结果 BODE评分与TNF-α存在明显正相关(r=0.455,P＜0.01),与IL-8也存在正相关(r=0.303,P＜0.05),与CRP无明显相关性(r=0.111,P=0.398)；IL-8与体质量指数(r=-0.417,P＜0.01)、第一秒用力呼气容积(r=-0.538,P＜0.01)、6 min步行距离(r=-0.419,P＜0.01)均呈明显负相关；TNF-α与体质量指数(r=-0.262,P＜0.05)、第一秒用力呼气容积(r=-0.348,P＜0.01)、6 min步行距离(r=-0.334,P＜0.01)均呈明显负相关.结论 BODE指数作为COPD的多维评价系统,与体内炎症反应状态有相关性,提示COPD患者的全身炎症反应可能参与了全身效应的发生发展.
목적 탐토만성조새성폐질병(COPD)환자전신염증반응여BODE지수적관계급의의.방법 채집60례은정기COPD환자BODE평분,병검측기혈청종류배사인자α(TNF-α)、백세포개소8(IL-8)급C반응단백(CRP).대BODE지수여염성인자적상관성진행분석.결과 BODE평분여TNF-α존재명현정상관(r=0.455,P＜0.01),여IL-8야존재정상관(r=0.303,P＜0.05),여CRP무명현상관성(r=0.111,P=0.398)；IL-8여체질량지수(r=-0.417,P＜0.01)、제일초용력호기용적(r=-0.538,P＜0.01)、6 min보행거리(r=-0.419,P＜0.01)균정명현부상관；TNF-α여체질량지수(r=-0.262,P＜0.05)、제일초용력호기용적(r=-0.348,P＜0.01)、6 min보행거리(r=-0.334,P＜0.01)균정명현부상관.결론 BODE지수작위COPD적다유평개계통,여체내염증반응상태유상관성,제시COPD환자적전신염증반응가능삼여료전신효응적발생발전.
Objective To assess the significance and the relationship of BODE index score and inflammation factors in stable chronic obstructive pulmonary disease(COPD).Methods Sixty COPD patients in their stable condition were evaluated for BODE index score and the level of tumor necrosis factor-α(TNF-α),interleukin-8(IL-8) and C reactive protein (CRP) were determined.Results BODE index score in COPD patients was positively correlated with serum concentrations of TNF-α,IL-8 (r =0.455,P ＜ 0.01 ; r =0.303,P ＜0.05),but not with CRP (r =0.111,P =0.398).IL-8 and TNF-α were both significantly negatively correlated to body mass index(BMI),force exhale volume of the first second (FEV1) and 6 minute walking distance (6MWD) (r=-0.417,P ＜0.01;r=-0.538,P＜0.01;r =-0.419,P＜0.01 for IL-8;and r=-0.262,P＜0.05;r=-0.348,P＜0.01;r=-0.334,P＜0.01 for TNF-α).Conclusion The BODE index,as a simple multidimensional grading system for COPD,is closely related to system inflammation,which indicates that system inflammation may contribute to the systemic development of COPD.