中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2013年
3期
267-270
,共4页
赵战云%颜炳丽%王春光%李松%郝力海%尹丽丽
趙戰雲%顏炳麗%王春光%李鬆%郝力海%尹麗麗
조전운%안병려%왕춘광%리송%학력해%윤려려
血液透析%髓过氧化物酶%糖尿病%颈动脉粥样硬化
血液透析%髓過氧化物酶%糖尿病%頸動脈粥樣硬化
혈액투석%수과양화물매%당뇨병%경동맥죽양경화
Hemodialysis%Myeloperoxidase%Diabetic%Carotid atherosclerosis disease
目的 调查维持性血液透析(MHD)的糖尿病患者血浆髓过氧化物酶(MPO)与颈动脉硬化相关指标的关系.方法 酶联免疫吸附法测定32例糖尿病MHD患者血液透析(HD)前后血浆MPO和血清弹性蛋白酶(ELT),同时B超测定两侧颈总动脉内膜中层厚度(CIMT)、斑块数量及面积,并对各项指标行相关性分析.结果 HD后患者血浆MPO浓度明显高于HD前[414.6(198.9,671.5)、176.4(69.9,243.3) μg/L,Z=-4.51、P＜0.01],HD前、后血清ELT浓度无变化[(201.9±100.5)、(229.8±179.4) μg/L,Z=-1.87,P＞0.05).秩相关检验结果表明,年龄与CIMT、双侧斑块数及斑块面积呈正相关(相关系数分别为0.764、0.416和0.446,P＜0.01或P＜0.05),HD前MPO浓度与年龄、HD前ELT及CIMT呈正相关(相关系数分别为0.592、0.476和0.810,P均＜0.01)；HD后MPO浓度与ELT正相关(相关系数为0.364,P＜0.05),与各项颈动脉硬化指标无相关性(P均＞0.05).结论(1)年龄及HD前血浆MPO浓度是糖尿病MHD患者动脉硬化的危险因素；(2)特定HD条件时HD后血浆MPO浓度的升高与动脉硬化程度无关.
目的 調查維持性血液透析(MHD)的糖尿病患者血漿髓過氧化物酶(MPO)與頸動脈硬化相關指標的關繫.方法 酶聯免疫吸附法測定32例糖尿病MHD患者血液透析(HD)前後血漿MPO和血清彈性蛋白酶(ELT),同時B超測定兩側頸總動脈內膜中層厚度(CIMT)、斑塊數量及麵積,併對各項指標行相關性分析.結果 HD後患者血漿MPO濃度明顯高于HD前[414.6(198.9,671.5)、176.4(69.9,243.3) μg/L,Z=-4.51、P＜0.01],HD前、後血清ELT濃度無變化[(201.9±100.5)、(229.8±179.4) μg/L,Z=-1.87,P＞0.05).秩相關檢驗結果錶明,年齡與CIMT、雙側斑塊數及斑塊麵積呈正相關(相關繫數分彆為0.764、0.416和0.446,P＜0.01或P＜0.05),HD前MPO濃度與年齡、HD前ELT及CIMT呈正相關(相關繫數分彆為0.592、0.476和0.810,P均＜0.01)；HD後MPO濃度與ELT正相關(相關繫數為0.364,P＜0.05),與各項頸動脈硬化指標無相關性(P均＞0.05).結論(1)年齡及HD前血漿MPO濃度是糖尿病MHD患者動脈硬化的危險因素；(2)特定HD條件時HD後血漿MPO濃度的升高與動脈硬化程度無關.
목적 조사유지성혈액투석(MHD)적당뇨병환자혈장수과양화물매(MPO)여경동맥경화상관지표적관계.방법 매련면역흡부법측정32례당뇨병MHD환자혈액투석(HD)전후혈장MPO화혈청탄성단백매(ELT),동시B초측정량측경총동맥내막중층후도(CIMT)、반괴수량급면적,병대각항지표행상관성분석.결과 HD후환자혈장MPO농도명현고우HD전[414.6(198.9,671.5)、176.4(69.9,243.3) μg/L,Z=-4.51、P＜0.01],HD전、후혈청ELT농도무변화[(201.9±100.5)、(229.8±179.4) μg/L,Z=-1.87,P＞0.05).질상관검험결과표명,년령여CIMT、쌍측반괴수급반괴면적정정상관(상관계수분별위0.764、0.416화0.446,P＜0.01혹P＜0.05),HD전MPO농도여년령、HD전ELT급CIMT정정상관(상관계수분별위0.592、0.476화0.810,P균＜0.01)；HD후MPO농도여ELT정상관(상관계수위0.364,P＜0.05),여각항경동맥경화지표무상관성(P균＞0.05).결론(1)년령급HD전혈장MPO농도시당뇨병MHD환자동맥경화적위험인소；(2)특정HD조건시HD후혈장MPO농도적승고여동맥경화정도무관.
Objective To study possible clinical relationships of myeloperoxidase (MPO) and carotid atherosclerosis in diabetic patients on maintenance hemodialysis(MHD).Methods Levels of plasma MPO and serum elastase (ELT) of diabetic patients on MHD were determined by enzyme-linked immunosorbent assay.Carotid intima media thickness(CIMT),quantity and area of carotid plaque were measured by B-mode ultrasonography.Results Plasma MPO was significantly higher after hemodialysis(HD) than before HD(414.6 (198.9,671.5) μg/L vs 176.4 (69.9,243.3) μg/L,Z =-4.51,P ＜ 0.01).There was no significant difference of serum ELT before and after HD(198.0(146.9,270.5) μg/L vs 230.9(40.2,308.0) μg/L,Z =-1.87,P ＞ 0.05).There was positive correlation between the age and CIMT,quantity or area of carotid plaqueor(correlation coefficient:0.764,0.416 and 0.446 respectively,P ＜ 0.01 or P ＜ 0.05),There was positive correlation between MPO level before HD and age,Levels of serum ELT before HD,or CIMT(correlation coefficient:0.592,0.476 and 0.810 respectively,P ＜ 0.01).There was positive correlation between MPO level after HD and levels of serum ELT after HD (correlation coefficient:0.364,P ＜ 0.05).There was no correlation between the levels of plasma MPO after HD and CIMT,quantity or area of carotid plaqueor (P ＞ 0.05).Conclusion (1) Age and MPO level before HD contribute to carotid atherosclerosis in patients on MHD.(2)There was no relation between higher MPO level after HD and carotid atherosclerosis.
