中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2013年
3期
275-277
,共3页
刘丽军%马燕霞%冯慧旻%邵丽莉%裴利敏%李琴%孟利民%李书香
劉麗軍%馬燕霞%馮慧旻%邵麗莉%裴利敏%李琴%孟利民%李書香
류려군%마연하%풍혜민%소려리%배리민%리금%맹이민%리서향
冠心病%C反应蛋白%白细胞介素6
冠心病%C反應蛋白%白細胞介素6
관심병%C반응단백%백세포개소6
Coronary artery disease%C-reactive protein%Interlekin-6
目的 探讨冠状动脉介入治疗对冠心病患者炎症指标及术后再狭窄的影响.方法 连续入选经冠状动脉介入治疗单支病变的冠心病患者90例(介入组),经冠状动脉造影证实冠状动脉正常的40例作为对照组.分别采用免疫浊度法和酶联免疫吸附法检测入选患者冠状动脉介入治疗前后超敏C反应蛋白(hs-CRP)和白细胞介素6(IL-6)的浓度.结果 (1)介入组患者术后血浆hs-CRP为(18.69±5.14) mg/L,显著高于术前的(14.45 ±4.32) mg,/L,差异有统计学意义(t=1.42,P＜0.01)；而对照组冠状动脉造影术后hs-CRP为(13.59±5.99) mg/L,与术前的(12.46 ±5.35) mg/L相比,差异无统计学意义(t=1.25,P＞0.05).(2)介入组患者术后血浆IL-6为(1.87 ±0.45) pg/L,显著高于术前的(1.35±0.39) pg/L,差异有统计学意义(t=1.33,P＜0.01)；而对照组冠状动脉造影术后IL-6为(1.32±0.41)pg/L,与术前的(1.21±0.38)pg/L相比,差异无统计学意义(t=1.16,P＞0.05).(3)介入组术后与对照组比较,血浆hs-CRP和IL-6差异有统计学意义(=4.96、t=6.61,P均＜0.01).结论 冠状动脉介入治疗促进冠心病患者血浆hs-CRP及IL-6的升高,是否为冠状动脉介入治疗术后支架内再狭窄的重要机制之一尚待进一步考证.
目的 探討冠狀動脈介入治療對冠心病患者炎癥指標及術後再狹窄的影響.方法 連續入選經冠狀動脈介入治療單支病變的冠心病患者90例(介入組),經冠狀動脈造影證實冠狀動脈正常的40例作為對照組.分彆採用免疫濁度法和酶聯免疫吸附法檢測入選患者冠狀動脈介入治療前後超敏C反應蛋白(hs-CRP)和白細胞介素6(IL-6)的濃度.結果 (1)介入組患者術後血漿hs-CRP為(18.69±5.14) mg/L,顯著高于術前的(14.45 ±4.32) mg,/L,差異有統計學意義(t=1.42,P＜0.01)；而對照組冠狀動脈造影術後hs-CRP為(13.59±5.99) mg/L,與術前的(12.46 ±5.35) mg/L相比,差異無統計學意義(t=1.25,P＞0.05).(2)介入組患者術後血漿IL-6為(1.87 ±0.45) pg/L,顯著高于術前的(1.35±0.39) pg/L,差異有統計學意義(t=1.33,P＜0.01)；而對照組冠狀動脈造影術後IL-6為(1.32±0.41)pg/L,與術前的(1.21±0.38)pg/L相比,差異無統計學意義(t=1.16,P＞0.05).(3)介入組術後與對照組比較,血漿hs-CRP和IL-6差異有統計學意義(=4.96、t=6.61,P均＜0.01).結論 冠狀動脈介入治療促進冠心病患者血漿hs-CRP及IL-6的升高,是否為冠狀動脈介入治療術後支架內再狹窄的重要機製之一尚待進一步攷證.
목적 탐토관상동맥개입치료대관심병환자염증지표급술후재협착적영향.방법 련속입선경관상동맥개입치료단지병변적관심병환자90례(개입조),경관상동맥조영증실관상동맥정상적40례작위대조조.분별채용면역탁도법화매련면역흡부법검측입선환자관상동맥개입치료전후초민C반응단백(hs-CRP)화백세포개소6(IL-6)적농도.결과 (1)개입조환자술후혈장hs-CRP위(18.69±5.14) mg/L,현저고우술전적(14.45 ±4.32) mg,/L,차이유통계학의의(t=1.42,P＜0.01)；이대조조관상동맥조영술후hs-CRP위(13.59±5.99) mg/L,여술전적(12.46 ±5.35) mg/L상비,차이무통계학의의(t=1.25,P＞0.05).(2)개입조환자술후혈장IL-6위(1.87 ±0.45) pg/L,현저고우술전적(1.35±0.39) pg/L,차이유통계학의의(t=1.33,P＜0.01)；이대조조관상동맥조영술후IL-6위(1.32±0.41)pg/L,여술전적(1.21±0.38)pg/L상비,차이무통계학의의(t=1.16,P＞0.05).(3)개입조술후여대조조비교,혈장hs-CRP화IL-6차이유통계학의의(=4.96、t=6.61,P균＜0.01).결론 관상동맥개입치료촉진관심병환자혈장hs-CRP급IL-6적승고,시부위관상동맥개입치료술후지가내재협착적중요궤제지일상대진일보고증.
Objective To investigate the impact of percutaneous coronary interventional (PCI) on the inflammatory indices and postoperative vascular restenosis.Methods This study involved 90 patients undergoing PCI procedures for Coronary artery disease (CAD) compromising a single coronary artery.Fourty healthy individuals with normal findings by coronary angiography were selected as the control group.Before and after PCI or coronary angiography,plasma hs-CRP and IL-6 were measured in all the subjects by immunonephelometry and enzyme-linked immunosorbant assay (ELISA),respectively.Results (1) In the CAD patients,the plasma hs-CRP level was significantly elevated after PCI as compared with the preoperative level((18.69 ±5.14) mg/L vs (14.45 ± 4.32) mg/L,t =1.42,P ＜ 0.01),whereas in the control group,the hs-CRP level underwent no significant changes after coronary angiography((13.59 ±5.99) mg/L vs(12.46 ±5.35) mg/L,t =1.25,P ＞ 0.05).(2) PCI procedures also resulted in significant elevation of plasma IL-6 level in the CAD patients((1.87±0.45) pg/L vs (1.35 ±0.39) pg/L,t =1.33,P＜0.01),but in the control group,IL-6 showed no significant variation after coronary angiography ((1.32 ± 0.41) pg/L vs (1.21 ± 0.38)pg/L,t =1.16,P ＞ 0.05).We observed significant difference of hs-CRP and IL-6 levels between the CAD patient group and the control group (t =4.96,6.61 respectively,P ＜ 0.01).Conclusion Plasma hs-CRP and IL-6 are elevated in CAD patients following PCI procedures.But the roles of elevated hs-CRP and IL-6 in the vascular restenosis following the procedures need further investigation.
