CAJ | 학술논문

目的探讨乳腺癌抗雌激素药物耐药蛋白基因(BCAR1)在子宫内膜样腺癌中的表达及其意义.方法应用免疫组织化学方法检测50例子宫内膜样腺癌和30例子宫内膜单纯性增生组织中BCAR1的表达,并检测雌激素受体(ER)、孕激素受体(PR)在子宫内膜样腺癌的表达.分析BCAR1的表达与子宫内膜样腺癌临床病理特征以及ER、PR的相关性.结果 BCAR1在子宫内膜样腺癌组织中的表达[64.0％ (32/50)]高于子宫内膜单纯性增生组织中的表达[40.0％ (12/30)],差异有统计学意义(x2 =4.364,P=0.037)；在子宫内膜样腺癌中,BCAR1的高表达与患者高龄、肿瘤细胞低分化和ER的阳性表达相关(x2值分别为6.272、5.640、4.217,r值分别为0.354、0.366、0.290；P均＜0.05).结论 BCAR1促进子宫内膜样腺癌的发生,并与肿瘤细胞低分化和ER表达状态呈正相关.
목적 탐토유선암항자격소약물내약단백기인(BCAR1)재자궁내막양선암중적표체급기의의.방법 응용면역조직화학방법검측50례자궁내막양선암화30례자궁내막단순성증생조직중BCAR1적표체,병검측자격소수체(ER)、잉격소수체(PR)재자궁내막양선암적표체.분석BCAR1적표체여자궁내막양선암림상병리특정이급ER、PR적상관성.결과 BCAR1재자궁내막양선암조직중적표체[64.0％ (32/50)]고우자궁내막단순성증생조직중적표체[40.0％ (12/30)],차이유통계학의의(x2 =4.364,P=0.037)；재자궁내막양선암중,BCAR1적고표체여환자고령、종류세포저분화화ER적양성표체상관(x2치분별위6.272、5.640、4.217,r치분별위0.354、0.366、0.290；P균＜0.05).결론 BCAR1촉진자궁내막양선암적발생,병여종류세포저분화화ER표체상태정정상관.
Objective To investigate the expression and significance of BCAR1 protein in endometrial carcinoma.Methods The level of BCAR1 was measured by immunohistochemistry in 50 endometrial carcinoma samples and 30 normal proliferative endometrium samples.Estrogen receptor (ER) and progesterone receptor (PR) expression was investigated in endometrial carcinoma samples.Results The level of BCAR1 was higher in endometrial carcinoma than that in normal proliferative endometrium (64.0％ (32/50) vs.40.0％ (12/30) ;x2 =4.364,P =0.037).In endometrial cancer,increased BCAR1 expression was significantly correlated with relatively higher age,poor differentiation,positive expression of ER (x2 =6.272,r =0.354 ; x2 =5.640,r =0.366 and x2 =4.217,r =0.290 ; P ＜ 0.05).Conclusion BCAR1 promote carcinogenesis and positively correlate with poor differentiation and ER status in endometrial carcinoma.