CAJ | 학술논문

目的探讨血管性认知障碍(VCI)患者血清脑源性神经营养因子(BDNF)水平的变化及其临床意义.方法入选40例VCI患者(VCI组),根据认知障碍的严重程度将VCI患者分为轻度认知障碍(MCI-V)组10例和血管性痴呆(VD)组30例,对照组为同期健康体检者40名.应用酶联免疫吸附试验对上述研究对象进行血清BDNF浓度检测,并进行统计学分析.结果 VCI组血清BDNF水平(0.175 ±0.056) ng/L低于正常对照组(0.211 ±0.061) ng/L,差异有统计学意义(t=-2.752,P＜0.05)；MCI-V组(0.195±0.067) ng/L与VD组(0.168±0.052) ng/L之间差异无统计学意义(t=1.310,P＞0.05),但均显著低于正常对照组(F=4.590,P均＜0.05).在VD患者中,皮层下小血管痴呆患者血清BDNF水平(0.178 ±0.057) ng/L与大血管痴呆(0.154 ±0.042) ng/L之间差异无统计学意义(t=1.278,P=0.212).结论 BDNF参与了VCI的病理生理过程,外周血BDNF水平可能为VCI的诊断标志物之一,但该指标不能反映VCI的严重程度,也不能用以区分不同类型的VCI.
목적 탐토혈관성인지장애(VCI)환자혈청뇌원성신경영양인자(BDNF)수평적변화급기림상의의.방법 입선40례VCI환자(VCI조),근거인지장애적엄중정도장VCI환자분위경도인지장애(MCI-V)조10례화혈관성치태(VD)조30례,대조조위동기건강체검자40명.응용매련면역흡부시험대상술연구대상진행혈청BDNF농도검측,병진행통계학분석.결과 VCI조혈청BDNF수평(0.175 ±0.056) ng/L저우정상대조조(0.211 ±0.061) ng/L,차이유통계학의의(t=-2.752,P＜0.05)；MCI-V조(0.195±0.067) ng/L여VD조(0.168±0.052) ng/L지간차이무통계학의의(t=1.310,P＞0.05),단균현저저우정상대조조(F=4.590,P균＜0.05).재VD환자중,피층하소혈관치태환자혈청BDNF수평(0.178 ±0.057) ng/L여대혈관치태(0.154 ±0.042) ng/L지간차이무통계학의의(t=1.278,P=0.212).결론 BDNF삼여료VCI적병리생리과정,외주혈BDNF수평가능위VCI적진단표지물지일,단해지표불능반영VCI적엄중정도,야불능용이구분불동류형적VCI.
Objective To investigate the clinical significance of brain-derived neurotrophic factor (BDNF) from peripheral serum in patients of vascular cognitive impairment (VCI).Methods Forty VCI subjects (including 10 mild cognitive impairment vascular(MCI-V) and 30 vascular dementia(VD)),and the control group for the same period in 40 healthy persons.Enzyme-linked immunosorbant assay (ELISA) was used to measure the serum levels of BDNF,statistical analysis was performed.Results The peripheral serum levels of BDNF in VCI (0.175 ±0.056) ng/L were lower than those of control group (0.211 ±0.061) ng/L,and there were significant differences (t =-2.752,P ＜ 0.05).The levels of BDNF showed no significant difference between MCI and VD ((0.195 ± 0.067) ng/L vs.(0.168 ± 0.052) ng/L,t =1.310,P ＞ 0.05).But they were both significantly lower than the control group (F =4.590,P =0.013).No significant differences were observed in the levels of BDNF between subcortical small vessel dementia (0.178 ± 0.057) ng/L and big vascular dementia (0.154 ± 0.042) ng/L (t =1.278,P =0.212).Conclusion BDNF participate in pathophysiology of VCI,and the serum levels of BDNF may be a candidate marker for clinical diagnosis of VCI.But serum levels of BDNF could not reflect the severity or the type of the VCI.