CAJ | 학술논문

目的观察体质量指数(BMI)变化对肱动脉-踝动脉脉搏波传导速度(baPWV)的影响.方法应用前瞻性队列研究,在2006-2007年度参加健康体检的101 510名开滦集团职工中随机分层抽取5852名作为研究对象,符合入选标准(年龄≥40岁、既往无缺血性脑卒中、短暂性脑缺血发作、心肌梗死者)的5440名纳入研究队列.依据2006-2007年度、2010-2011年度两次BMI测量数据将观察对象分为BMI持续正常组(1720名)、BMI降低组(367名)、BMI升高组(467名)、BMI持续高组(2626名).用多因素Logistic回归方法分析BMI变化对baPWV的影响.结果 (1)全人群BMI降低组的动脉硬化检出率67.8％(249/367)和BMI持续高组的动脉硬化检出率65.9％(1730/2626)；较BMI持续正常组56.3％(969/1720)和BMI升高组55.5％(259/467)明显升高,差异有统计学意义(F=53.93,P＜0.01).(2)在女性人群中,校正了基线年龄,甘油三酯,总胆固醇,高密度脂蛋白胆固醇,空腹血糖,超敏C反应蛋白,吸烟,饮酒,原发性高血压后,与BMI持续正常组相比,BMI持续高组增加动脉硬化的发病风险高(RR为1.34,95％ CI为1.03～1.74,P＜0.05).结论 BMI长期持续在较高水平会加快女性脉搏波传导速度.
목적 관찰체질량지수(BMI)변화대굉동맥-과동맥맥박파전도속도(baPWV)적영향.방법 응용전첨성대렬연구,재2006-2007년도삼가건강체검적101 510명개란집단직공중수궤분층추취5852명작위연구대상,부합입선표준(년령≥40세、기왕무결혈성뇌졸중、단잠성뇌결혈발작、심기경사자)적5440명납입연구대렬.의거2006-2007년도、2010-2011년도량차BMI측량수거장관찰대상분위BMI지속정상조(1720명)、BMI강저조(367명)、BMI승고조(467명)、BMI지속고조(2626명).용다인소Logistic회귀방법분석BMI변화대baPWV적영향.결과 (1)전인군BMI강저조적동맥경화검출솔67.8％(249/367)화BMI지속고조적동맥경화검출솔65.9％(1730/2626)；교BMI지속정상조56.3％(969/1720)화BMI승고조55.5％(259/467)명현승고,차이유통계학의의(F=53.93,P＜0.01).(2)재녀성인군중,교정료기선년령,감유삼지,총담고순,고밀도지단백담고순,공복혈당,초민C반응단백,흡연,음주,원발성고혈압후,여BMI지속정상조상비,BMI지속고조증가동맥경화적발병풍험고(RR위1.34,95％ CI위1.03～1.74,P＜0.05).결론 BMI장기지속재교고수평회가쾌녀성맥박파전도속도.
Objective To observe the effect of change in body mass index(BMI) on brachial-ankle pulse wave velocity (baPWV).Methods Prospective cohort study was used to stratify random sampling 5852 workers as the study investigated from the total Kailuan group number 101 510 from 2006 to 2007.The inclusion criteria is age ≥ 40 years,no previous history of ischemic stroke,transient ischemic attack,myocardial infarction.,and 5440 were meet the standard.According to the BMI measurements in the two times health examinations between 2006 to 2007 and 2010 to 2011,the observed population divided into four groups:including continued normal group (1720 cases),decreasing group (367 cases),increasing group (467 cases) and continued high group (2626 cases).Multiple logistic regression analysis was used to test the effect of change of BMI on baPWV.Results (1) The arteriosclerosis detection rate of decreased BMI group is 67.8％ (249/367)and of continued high BMI group is 65.9％ (1730/2626),BMI continued normal group 56.3％ (969/1720)and the BMI elevated group is 55.5％ (259/467).Compared with BMI of continued normal group,BMI of decreasing group and continued high group have a significantly higher of arteriosclerosis (F =53.93,P ＜ 0.01).(2) In the female population,adjusted the baseline of age,triglycerides,total cholesterol,high density lipoprotein cholesterol,fasting blood glucose,high-sensitivity C-reactive protein,smoking,alcohol consumption and hypertension,BMI of continued high group appears to be an independent risk factor for baPWV (RR =1.34,95％ CI =1.03-1.74,P ＜ 0.05),compared with BMI of continued normal group.Conclusion Keep a high level of BMI for a long time can accelerate pulse wave velocity among women.