中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2013年
6期
586-590
,共5页
慢性阻塞性肺疾病%同型半胱氨酸%超敏C反应蛋白
慢性阻塞性肺疾病%同型半胱氨痠%超敏C反應蛋白
만성조새성폐질병%동형반광안산%초민C반응단백
Chronic obstructive pulmonary disease%Homocysteine%High sensitivity C-response protein
目的 探讨血浆同型半胱氨酸(Hcy)与血浆超敏C反应蛋白(hs-CRP)在慢性阻塞性肺疾病(COPD)发病机制中的作用,并观察其与疾病严重程度是否相关以及二者的相关性.方法 收集2010年8月至2011年2月黑龙江省医院呼吸内科确诊为COPD住院患者41例(观察组)；同时选取同期来我院的健康体检者35名为对照组.均检测血浆Hcy、血浆hs-CRP、第1秒用力呼气容积占预计值百分比(FEV1％预计值)、动脉血氧分压(PaO2),进行比较分析.结果 血浆Hcy浓度观察组为(22.07±12.13) μmol/L,对照组为(9.89±4.41) μmol/L,观察组较对照组显著增显高,差异有统计学意义(t=1.674,P＜0.01).血浆hs-CRP浓度观察组为(8.60±3.85) mg/L,对照组为(4.24±0.57) mg/L,观察组较对照组显著增高,差异有统计学意义(t=1.682,P＜0.01).观察组随FEV1％预计值降低,血浆Hcy和hs-CRP浓度逐渐升高,FEV1％预计值与血浆Hcy及血浆hs-CRP均呈负相关(r=-0.45及-0.49,P均＜0.05).观察组血浆Hcy浓度与血浆hs-CRP浓度呈正相关(r=0.68,P＜0.01).结论 COPD患者血浆Hcy、hs-CRP浓度明显升高,与FEV 1％预计值呈负相关；Hcy与hs-CRP二者呈正相关.
目的 探討血漿同型半胱氨痠(Hcy)與血漿超敏C反應蛋白(hs-CRP)在慢性阻塞性肺疾病(COPD)髮病機製中的作用,併觀察其與疾病嚴重程度是否相關以及二者的相關性.方法 收集2010年8月至2011年2月黑龍江省醫院呼吸內科確診為COPD住院患者41例(觀察組)；同時選取同期來我院的健康體檢者35名為對照組.均檢測血漿Hcy、血漿hs-CRP、第1秒用力呼氣容積佔預計值百分比(FEV1％預計值)、動脈血氧分壓(PaO2),進行比較分析.結果 血漿Hcy濃度觀察組為(22.07±12.13) μmol/L,對照組為(9.89±4.41) μmol/L,觀察組較對照組顯著增顯高,差異有統計學意義(t=1.674,P＜0.01).血漿hs-CRP濃度觀察組為(8.60±3.85) mg/L,對照組為(4.24±0.57) mg/L,觀察組較對照組顯著增高,差異有統計學意義(t=1.682,P＜0.01).觀察組隨FEV1％預計值降低,血漿Hcy和hs-CRP濃度逐漸升高,FEV1％預計值與血漿Hcy及血漿hs-CRP均呈負相關(r=-0.45及-0.49,P均＜0.05).觀察組血漿Hcy濃度與血漿hs-CRP濃度呈正相關(r=0.68,P＜0.01).結論 COPD患者血漿Hcy、hs-CRP濃度明顯升高,與FEV 1％預計值呈負相關；Hcy與hs-CRP二者呈正相關.
목적 탐토혈장동형반광안산(Hcy)여혈장초민C반응단백(hs-CRP)재만성조새성폐질병(COPD)발병궤제중적작용,병관찰기여질병엄중정도시부상관이급이자적상관성.방법 수집2010년8월지2011년2월흑룡강성의원호흡내과학진위COPD주원환자41례(관찰조)；동시선취동기래아원적건강체검자35명위대조조.균검측혈장Hcy、혈장hs-CRP、제1초용력호기용적점예계치백분비(FEV1％예계치)、동맥혈양분압(PaO2),진행비교분석.결과 혈장Hcy농도관찰조위(22.07±12.13) μmol/L,대조조위(9.89±4.41) μmol/L,관찰조교대조조현저증현고,차이유통계학의의(t=1.674,P＜0.01).혈장hs-CRP농도관찰조위(8.60±3.85) mg/L,대조조위(4.24±0.57) mg/L,관찰조교대조조현저증고,차이유통계학의의(t=1.682,P＜0.01).관찰조수FEV1％예계치강저,혈장Hcy화hs-CRP농도축점승고,FEV1％예계치여혈장Hcy급혈장hs-CRP균정부상관(r=-0.45급-0.49,P균＜0.05).관찰조혈장Hcy농도여혈장hs-CRP농도정정상관(r=0.68,P＜0.01).결론 COPD환자혈장Hcy、hs-CRP농도명현승고,여FEV 1％예계치정부상관；Hcy여hs-CRP이자정정상관.
Objective To investigate the functions of blood plasma homocysteine (Hcy) and high sensitivity C-response protein (hs-CRP) in the chronic obstructive pulmonary disease (COPD) in pathogenesis plays,and observe whether there was associations with disease severity and the correlations.Methods Forty-one patients with COPD were collected from August 2010 to February 2011,and 35 healthy persons as control group.Blood plasma Hcy,hs-CRP,forced expiratory volume in one second account predicted (FEV1％ predicted),and arterial pressure of oxygen (PaO2,arterial blood gases analysis) were measured in COPD patients and controls.Results Plasma Hcy concentration was (22.07 ± 12.13) μmol/L in COPD patients,but (9.89 ±4.41) μmol/L in controls,there were significant differences between two subjects (t =1.674,P ＜0.01).COPD patients had a higher serum hs-CRP concentration (8.60±3.85) mg/L than control's (4.24 ±0.57) mg/L (t =1.682,P ＜ 0.01).Along the descent of FEV1％ predicted,plasma Hcy and hs-CRP were elevated gradually,both sides show a negative correlation (r =-0.45,-0.49,P ＜ 0.05).And plasma Hcy and hs-CRP present a positive correlation in COPD patients (r =0.68,P ＜ 0.01).Conclusion Plasma Hcy was significantly elevated in COPD patients,positive correlation related to COPD severity and positive correlation related to serum hs-CRP.
