CAJ | 학술논문

目的探讨血管危险因素与前、后循环颅内动脉狭窄之间的关系.方法对374例急性脑梗死患者进行磁共振血管成像检查,按颅内动脉狭窄的部位分两组(前、后循环颅内动脉狭窄组),对可能影响前、后循环颅内动脉狭窄的危险因素进行分析比较.结果单因素分析发现前、后循环颅内动脉狭窄在收缩压、吸烟史、饮酒史、卒中史、出院时国立卫生研究院卒中量表(NIHSS)评分、短期预后、血肌酐、血甘油三酯、低密度脂蛋白胆固醇(LDL-C)间差异均有统计学意义(P均＜0.05).多因素Logistic回归分析显示,前循环颅内动脉狭窄与高血糖(OR=1.135,95％ CI:1.003～1.284)、卒中史(OR=1.133,95％ CI:1.007 ～1.276)、短期预后(OR =5.987,95％ CI:1.441～24.873)有关,后循环颅内动脉狭窄与吸烟史(OR=0.003,95％ CI:0.000 ～0.376)、血肌酐(OR=0.509,95％ CI:0.328 ～0.790)、高甘油三酯(OR=0.054,95％ CI:0.004 ～0.645)、高LDL-C(OR=0.096,95％ CI:0.015～0.608)有关.结论血管性危险因素对前、后循环颅内动脉狭窄所施加的效应是不同的.
목적 탐토혈관위험인소여전、후순배로내동맥협착지간적관계.방법 대374례급성뇌경사환자진행자공진혈관성상검사,안로내동맥협착적부위분량조(전、후순배로내동맥협착조),대가능영향전、후순배로내동맥협착적위험인소진행분석비교.결과 단인소분석발현전、후순배로내동맥협착재수축압、흡연사、음주사、졸중사、출원시국립위생연구원졸중량표(NIHSS)평분、단기예후、혈기항、혈감유삼지、저밀도지단백담고순(LDL-C)간차이균유통계학의의(P균＜0.05).다인소Logistic회귀분석현시,전순배로내동맥협착여고혈당(OR=1.135,95％ CI:1.003～1.284)、졸중사(OR=1.133,95％ CI:1.007 ～1.276)、단기예후(OR =5.987,95％ CI:1.441～24.873)유관,후순배로내동맥협착여흡연사(OR=0.003,95％ CI:0.000 ～0.376)、혈기항(OR=0.509,95％ CI:0.328 ～0.790)、고감유삼지(OR=0.054,95％ CI:0.004 ～0.645)、고LDL-C(OR=0.096,95％ CI:0.015～0.608)유관.결론 혈관성위험인소대전、후순배로내동맥협착소시가적효응시불동적.
Objective To investigate the association between vascular risk factors and the location of intracranial artery stenosis (anterior versus posterior).Methods Magnetic resonance angiography(MRA) were examined in 374 acute stroke patients.It was divided into two groups (anterior and posterior intracranial artery stenosis group).Analyzed possible risk factors.Results Univariate analysis showed there were differences between anterior and posterior intracranial artery stenosis in systolic blood pressure,history of smoking,drinking and stroke status,and national institutes of health stroke scale (NIHSS) score at discharge,short-term prognosis,serum creatinine,triglyceride,low density lipoprotein cholesterol (LDL-C) (P ＜ 0.05).In multivariate logistic regression analysis,high blood sugar (OR =1.135,95％ CI:1.003-1.284),history of stroke(OR =1.133,95％ CI:1.007-1.276),good short-term prognosis (OR =5.987,95％ CI:1.441-24.873) were preferentially related to anterior intracranial artery stenosis,whereas history of smoking (OR =0.003,95 ％ CI:0.000-0.376),high serum creatinine values (OR =0.509,95 ％ CI:0.328-0.790),high triglyceride values (OR =0.054,95％ CI:0.004-0.645) and high LDL-C values (OR =0.096,95％ CI:0.015-0.608) were preferentially related to posterior intracranial artery stenosis.Conclusion Vascular risk factors appeared to exert different effects of risk for anterior and posterior intracranial artery stenosis.