CAJ | 학술논문

目的比较南方地区2型糖尿病患者与健康体检者血清25羟维生素D3[25 (OH) D3]的浓度,探讨25(OH)D3在2型糖尿病发病中的临床意义.方法选择2型糖尿病患者147例为2型糖尿病组,同期我院健康体检者135例为对照组.采用ELISA法测定血清25 (OH) D3浓度,记录一般临床资料并检测相关生化指标,并进行统计分析.结果 (1)2型糖尿病组患者血清25(OH) D3浓度较低,但2型糖尿病组和对照组之间以及两组人群男、女性别之间比较差异均无统计学意义[T2DM组为(23.10±1.59) μg/L,对照组(23.11 ±1.65) μg/L(t =0.064,P=0.949).T2DM组男、女性患者血清25 (OH) D3浓度分别为(23.22±1.54)、(22.95±1.65) μg/L(t=0.209,P＞0.05).对照组男、女研究对象血清25(OH)D3浓度分别为(23.03±1.73)、(23.18±1.59) μg/L(t =0.436,P＞0.05)；(2)维生素D不足和缺乏的比例在T2DM组比较高,但两组人群之间比较差异无统计学意义(分别为98.0％与94.8％,2.0％与5.2％；x2=2.034,P=0.154); (3)2型糖尿病患者血清25(OH) D3与甘油三酯呈显著负相关(r=-0.218,P＜0.01).结论 (1)南方地区健康人群和T2DM患者维生素D水平均低下,且维生素D不足和缺乏的比例达90％以上；(2)甘油三酯是T2DM患者的独立危险因子.
목적 비교남방지구2형당뇨병환자여건강체검자혈청25간유생소D3[25 (OH) D3]적농도,탐토25(OH)D3재2형당뇨병발병중적림상의의.방법 선택2형당뇨병환자147례위2형당뇨병조,동기아원건강체검자135례위대조조.채용ELISA법측정혈청25 (OH) D3농도,기록일반림상자료병검측상관생화지표,병진행통계분석.결과 (1)2형당뇨병조환자혈청25(OH) D3농도교저,단2형당뇨병조화대조조지간이급량조인군남、녀성별지간비교차이균무통계학의의[T2DM조위(23.10±1.59) μg/L,대조조(23.11 ±1.65) μg/L(t =0.064,P=0.949).T2DM조남、녀성환자혈청25 (OH) D3농도분별위(23.22±1.54)、(22.95±1.65) μg/L(t=0.209,P＞0.05).대조조남、녀연구대상혈청25(OH)D3농도분별위(23.03±1.73)、(23.18±1.59) μg/L(t =0.436,P＞0.05)；(2)유생소D불족화결핍적비례재T2DM조비교고,단량조인군지간비교차이무통계학의의(분별위98.0％여94.8％,2.0％여5.2％；x2=2.034,P=0.154); (3)2형당뇨병환자혈청25(OH) D3여감유삼지정현저부상관(r=-0.218,P＜0.01).결론 (1)남방지구건강인군화T2DM환자유생소D수평균저하,차유생소D불족화결핍적비례체90％이상；(2)감유삼지시T2DM환자적독립위험인자.
Objective To investigate the significance of 25 hydroxyvitamin D3 (25 (OH)D3) in patients with type 2 diabetes mellitus by comparing the differences of serum 25-hydroxyvitamin D levels between type 2 diabetes mellitus patients and healthy people.Methods One hundred and forty-seven patients with type 2 diabetes mellitus were selected as the T2DM group,and 135 healthy people were selected as the normal control (NC) group.The level of serum 25 (OH) D3 was detected by ELISA.Clinical data were recorded and biochemical indexes were also detected.Statistical analysis was performed.Results (1) Serum 25 (OH) D3 level in T2DM group was low,but there was no significant difference between two groups((23.10 ± 1.59) μg/L vs.(23.11 ± 1.65) μg/L; t =0.064,P =0.949),as well as between men and women in the 2 populations (T2DM men vs.women(23.22 ± 1.54) μg/L vs.(22.95 ± 1.65) μg/L; t =0.209,P ＞0.05; NC men vs women(23.03 ± 1.73) μg/L vs.(23.18 ± 1.59) μg/L; t =0.436,P ＞0.05) ; (2)The prevalence of vitamin D insufficient and deficiency in T2DM group was high,but it was not statistically significant between two groups (98.0％ vs.94.8 ％ and 2.0％ vs.5.2％ ; x2 =2.034,P =0.154) ; (3) Serum 25 (OH) D3 in T2DM group has a significant negative correlation with triglycerides (r =-0.218,P ＜ 0.01).Conclusion (1) Vitamin D level was low in both the healthy and T2DM populations in the southern region of China,the prevalence of vitamin D insufficient and deficiency was up to 90％.(2)Triglyceride is the only independent risk factor to T2DM population.