CAJ | 학술논문

目的探讨解聚素-金属蛋白酶-17(ADAM17)在人脑胶质瘤的表达及其临床意义.方法采用免疫组织化学方法检测人脑胶质瘤组织中ADAM17蛋白的表达,并分析其与胶质瘤恶性程度的关系.结果 ADAM17在人脑胶质瘤中表达增多,且随着恶性程度的提高,表达也进一步增多.正常人脑组织中ADAM17呈微量表达(以弱阳性表达为主),人脑胶质瘤组织中ADAM17的表达增强,其中低度恶性组表达以阳性为主[75％(18/24)],另有1例为强阳性；高度恶性组以强阳性表达为主[82.1％(23/28)].结论 ADAM17在人脑胶质瘤中表达增强,且随着恶性程度的增加,表达也逐渐增强,提示ADAM17可能在胶质瘤的发生、发展中发挥着一定的作用.
목적 탐토해취소-금속단백매-17(ADAM17)재인뇌효질류적표체급기림상의의.방법 채용면역조직화학방법검측인뇌효질류조직중ADAM17단백적표체,병분석기여효질류악성정도적관계.결과 ADAM17재인뇌효질류중표체증다,차수착악성정도적제고,표체야진일보증다.정상인뇌조직중ADAM17정미량표체(이약양성표체위주),인뇌효질류조직중ADAM17적표체증강,기중저도악성조표체이양성위주[75％(18/24)],령유1례위강양성；고도악성조이강양성표체위주[82.1％(23/28)].결론 ADAM17재인뇌효질류중표체증강,차수착악성정도적증가,표체야축점증강,제시ADAM17가능재효질류적발생、발전중발휘착일정적작용.
Objective To investigate the expression and its clinical significance of adisintegrin and metalloprotease-17 (ADAM17) in human glioma.Methods The expressions of ADAM17 in human glioma were detected by immunohistochemical staining.The correlation between ADAM17 expression and the malignance of glioma was analyzed.Results Expression of ADAM17 in human gliomas increased.With the malignant degree,ADAM17 expression has also further increased.However,there was a less ADAM17 expression in normal human brain.The positive expression of ADAM17 in low malignant group was 75％ (18/24),of which 1 case were strong positive.The strong positive expression of ADAM17 was the majority (82.1％,23/28) in malignant group.Conclusion The expression of ADAM-17 was higher in human brain gliomas.With malignance degree increased,of the ADAM-17 expression has gradually increased,suggesting that ADAM-17 might play a certain role in the occurrence and development of glioma.