CAJ | 학술논문

目的探讨十二指肠乳头癌组织中桩蛋白与碳酸酐酶Ⅸ(CAⅨ)的表达及意义.方法应用免疫组织化学方法检测87例十二指肠乳头癌组织中桩蛋白与CAⅨ的表达情况.结果桩蛋白表达阳性率为74.7％(65/87),明显高于癌旁组织[41.0％(16/39)]和十二指肠乳头炎组织[41.3％(19/46),差异有统计学意义(x2=19.869,P＜0.05).CAⅨ表达阳性率为71.3％(62/87),明显高于癌旁组织[33.3％ (13/39)]和十二指肠乳头炎组织[30.4％ (14/46),差异有统计学意义(x2=26.936,P＜0.05).随着癌组织恶性程度以及远隔转移程度的增加,桩蛋白与CAⅨ的表达随之增强.结论桩蛋白与CAⅨ是对十二指肠乳头癌进行早期诊断以及判断预后的重要指标.
목적 탐토십이지장유두암조직중장단백여탄산항매Ⅸ(CAⅨ)적표체급의의.방법 응용면역조직화학방법검측87례십이지장유두암조직중장단백여CAⅨ적표체정황.결과 장단백표체양성솔위74.7％(65/87),명현고우암방조직[41.0％(16/39)]화십이지장유두염조직[41.3％(19/46),차이유통계학의의(x2=19.869,P＜0.05).CAⅨ표체양성솔위71.3％(62/87),명현고우암방조직[33.3％ (13/39)]화십이지장유두염조직[30.4％ (14/46),차이유통계학의의(x2=26.936,P＜0.05).수착암조직악성정도이급원격전이정도적증가,장단백여CAⅨ적표체수지증강.결론 장단백여CAⅨ시대십이지장유두암진행조기진단이급판단예후적중요지표.
Objective To investigate the pile protein (paxillin) and carbonic anhydrases Ⅸ (CA Ⅸ)expression and its significance in duodenal papilla carcinoma patients.Methods Eighty-seven cases of duodenal papilla carcinoma were enrolled as our subject.Immunohistochemical staining was used to detect the expressions of paxillin and CAⅨ in site of tumor,adjacent tissue and duodenal papillitis tissue.Results Sixtyfive cases (74.7％ (65/87)) were showed a higher expression of paxillin in cancer site than that of adjacent tissue (41％ (16/39),P ＜ 0.05) and duodenal papillitis tissue (41.3％ (19/46),P ＜ 0.05),and the difference was statisically significant (x2 =19.869,P ＜0.05).While a higher expression of CA Ⅸ in 62 cases (71.3％) in cancer site was seen,higher than that of adjacent tissue (33.3％ (13/39),P ＜ 0.05) and duodenal papillitis tissue (30.4％ (14/46),P ＜ 0.05),and the difference was statisically significant (x2 =26.936,P ＜ 0.05).As the increase of the cancer tissue malignant degree and the surrounding tissue invasion or distant metastasis degree,paxillin and CA Ⅸ expression increased.Conclusion The paxillin and CAⅨ might served as the early indicators for diagnosis and judgment of prognosis of duodenal papilla cancer.