CAJ | 학술논문

目的观察迈之灵治疗乳腺癌根治术后常见并发症的临床效果.方法选取我院乳腺癌根治术后患者120例,随机分为两组:对照组60例,给予术后常规治疗；治疗组60例,在术后常规治疗基础上加用迈之灵治疗,300 mg口服,2次/d,疗程4周.观察比较两组的疗效.结果 (1)缓解皮瓣下淤血时间的效果:治疗组在术后第1、2周皮瓣下淤血消失率分别为80.0％ (48/60)和93.3％ (56/60),明显优于对照组的60.0％(36/60)和71.6％(43/60),差异有统计学意义(P均＜0.05).3周后皮瓣下淤血缓解率差异无统计学意义(P＞0.05).(2)缓解患侧上肢水肿的效果:治疗后治疗组总有效率93％(56/60)较对照组的77％(46/60)高,差异有统计学意义(x2 =5.17,P＜0.05).(3)两组视觉模拟评分(VAS)比较:两组自身治疗后VAS疼痛评分均显著下降[治疗组由治疗前(8.87±0.74)分下降到治疗后的(3.21±0.92)分；对照组由治疗前(8.91±0.85)分下降到治疗后的(4.87±1.34)分],差异有统计学意义(P均＜0.05),但治疗组对改善VAS疼痛评分效果明显优于对照组(P＜0.05).(4)整个用药过程中未见不良反应发生.结论迈之灵可以缩短乳腺癌根治术后皮瓣下淤血的消失时间,缩短患侧上肢肿胀和疼痛等主观症状的恢复时间.
목적 관찰매지령치료유선암근치술후상견병발증적림상효과.방법 선취아원유선암근치술후환자120례,수궤분위량조:대조조60례,급여술후상규치료；치료조60례,재술후상규치료기출상가용매지령치료,300 mg구복,2차/d,료정4주.관찰비교량조적료효.결과 (1)완해피판하어혈시간적효과:치료조재술후제1、2주피판하어혈소실솔분별위80.0％ (48/60)화93.3％ (56/60),명현우우대조조적60.0％(36/60)화71.6％(43/60),차이유통계학의의(P균＜0.05).3주후피판하어혈완해솔차이무통계학의의(P＞0.05).(2)완해환측상지수종적효과:치료후치료조총유효솔93％(56/60)교대조조적77％(46/60)고,차이유통계학의의(x2 =5.17,P＜0.05).(3)량조시각모의평분(VAS)비교:량조자신치료후VAS동통평분균현저하강[치료조유치료전(8.87±0.74)분하강도치료후적(3.21±0.92)분；대조조유치료전(8.91±0.85)분하강도치료후적(4.87±1.34)분],차이유통계학의의(P균＜0.05),단치료조대개선VAS동통평분효과명현우우대조조(P＜0.05).(4)정개용약과정중미견불량반응발생.결론 매지령가이축단유선암근치술후피판하어혈적소실시간,축단환측상지종창화동통등주관증상적회복시간.
Objective To investigate the treatment effect of aescuven forte on the postoperative complications of breast cancer.Methods One hundred and twenty patients with breast cancer radical surgery were randomly divided into control group(n =60) and treatment group(n =60).Patients in control group were given postoperative routine treatment,while in treatment group were administrated aescuven forte pills at 300 mg orally,2 times/day for 4 weeks beside the conventional treatment.Results (1)After the 1st,2nd weeks therapy,the flap congestion disappear rate in the treatment group were 80.0％ (48/60) and 93.3％ (56/60),better than that in the control group 60.0％ (36/60) and 71.6％ (43/60),the difference was statistically significant (P ＜ 0.05).However this trend was not seen in third weeks treatment (P ＞ 0.05).(2) The total efficiency of remission of upper limb edema was 93％ (56/60),higher than that in control group 77％ (46/60),the difference was statistically significant(x2 =5.17,P ＜ 0.05).(3) Visual analogue scale(VAS) pain score in treatment group were decreased form (8.87 ±0.74) in before treatment to (3.21 ±0.92) at after treatment.And the VAS score in control was from (8.91 ±0.85) down to (4.87 ± 1.34),the difference was statistically significant (P ＜ 0.05).Moreover VAS score in treatment group was lower than that in control group (P ＜ 0.05).(4) There was no adverse effect of the medication process.Conclusion Aescuven forte showed a ability to reduce congestion disappear time of breast cancer and shorten the recovery time of upper limb swelling and pain and other symptoms.