超重、肥胖成人肺功能及代谢指标相关研究
초중、비반성인폐공능급대사지표상관연구
The relationship between pulmonary function or metabolic indexes in overweight or obesity adults
  • 万方数据
    中国综合临床 중국종합림상
    CLINICAL MEDICINE OF CHINA
    2014年 1期 44-48 ,共5页

    张蒙%邓笑伟

    장몽%산소위

    体质量指数%肺功能%代谢指标 體質量指數%肺功能%代謝指標
    체질량지수%폐공능%대사지표
    Body mass index%Pulmonary function%Metabolic indexes
    目的 探讨超重、肥胖与肺功能及代谢指标的相关关系.方法 对305名健康体检者进行基本参数、代谢指标和肺功能的测定,采用单因素方差分析和Pearson相关分析的统计方法分析各组间肺功能[包括用力肺活量(FVC),第1秒用力呼出量(FEV1),呼气峰值流速(PEF),第1秒用力呼气量占用力肺活量比值(FEV1/FVC),第1秒用力呼气量占肺活量比值(FEV1/VC),50％最大肺活量时的最大呼气流速(MEF50),25％最大肺活量时的最大呼气流速(MEF25),为了消除性别、年龄、身高、体质量对肺功能测定值的影响,肺功能各指标结果均以实测值占预计值百分比表示]、代谢指标[包括甘油三酯(TG),总胆固醇(TC),低密度脂蛋白胆固醇(LDL-C),空腹血糖(FPG)]、C反应蛋白(CRP)、超敏C反应蛋白(hs-CRP)、超氧化物歧化酶(SOD)、收缩压(SBP)、舒张压(DBP)的关系.结果 超重组、肥胖组FVC[(85.74±13.94)％、(82.85±13.34)％]、FEV1[(84.52±14.62)％、(82.74±14.18)％]、FEV1/FVC[(103.40±13.05)％、(103.17±8.99)％]均低于正常体质量组[FVC:(95.79±26.83)％、FEV1:(92.65±26.93)％、EV1/FVC:(99.98±11.88)％](P均＜0.05).与正常体质量组相比,超重组和肥胖组中TG、SBP、FPG明显增高[超重组、肥胖组和正常体质量组TG分别为(2.23±1.66)、(2.52±1.57)、(1.63±1.45) mmol/L(P均＜0.05),SBP分别为(127.77±19.07)、(137.52±16.98)(125.56±20.30)mmHg(P均＜0.05),FPG分别为(6.32±1.57)、(6.56±1.75) (5.86±1.32) mmol/L(P均＜0.05)];肥胖组和正常体质量组LDL-C分别为(5.05±0.83)、(3.08±0.96) mmol/L,DBP分别为(86.64±10.49)、(77.69±13.20) mmHg,hs-CRP分别为(3.74±5.51)、(2.33±4.67) mg/L,两组比较差异均有统计学意义(P均＜0.05);超重、肥胖组SOD明显减低[超重组、肥胖组和正常体重组SOD分别为(140.82±13.16)、(144.89±13.82)、(148.64±14.94) U/L(P均＜0.05)];与肥胖组比较,超重组SBP、DBP、hs-CRP明显降低[超重组SBP:(127.77±19.07) mmHg、DBP:(80.87±12.21) mmHg,hs-CRP:(2.31±3.73) mg/L](P均＜0.05).代谢指标中TG、SBP、DBP、FPG、CRP、hs-CRP与FVC呈负相关,相关系数依次为-0.129、-0.129、-0.136、-0.180、-0.220、-0.217(P＜0.05或P＜0.01).SBP、FPG、CRP、hs-CRP与FEV1呈负相关,相关系数依次为-0.128、-0.127、-0.148、-0.198(P＜0.05或P＜0.01).SBP、CRP、hs-CRP与PEF呈负相关,相关系数依次为-0.137、-0.117、-0.133(P均＜0.05).hs-CRP、SBP与MEF50呈负相关,相关系数依次为-0.126、-0.124(P均＜0.05).SOD与FVC、PEF、FEV1/FEV、MEF50均呈正相关,相关系数依次为0.149、0.119、0.141、0.129(P＜0.05或P＜0.01).结论 肥胖导致肺功能受损伴代谢紊乱.代谢指标与肺功能相关.
    목적 탐토초중、비반여폐공능급대사지표적상관관계.방법 대305명건강체검자진행기본삼수、대사지표화폐공능적측정,채용단인소방차분석화Pearson상관분석적통계방법분석각조간폐공능[포괄용력폐활량(FVC),제1초용력호출량(FEV1),호기봉치류속(PEF),제1초용력호기량점용력폐활량비치(FEV1/FVC),제1초용력호기량점폐활량비치(FEV1/VC),50％최대폐활량시적최대호기류속(MEF50),25％최대폐활량시적최대호기류속(MEF25),위료소제성별、년령、신고、체질량대폐공능측정치적영향,폐공능각지표결과균이실측치점예계치백분비표시]、대사지표[포괄감유삼지(TG),총담고순(TC),저밀도지단백담고순(LDL-C),공복혈당(FPG)]、C반응단백(CRP)、초민C반응단백(hs-CRP)、초양화물기화매(SOD)、수축압(SBP)、서장압(DBP)적관계.결과 초중조、비반조FVC[(85.74±13.94)％、(82.85±13.34)％]、FEV1[(84.52±14.62)％、(82.74±14.18)％]、FEV1/FVC[(103.40±13.05)％、(103.17±8.99)％]균저우정상체질량조[FVC:(95.79±26.83)％、FEV1:(92.65±26.93)％、EV1/FVC:(99.98±11.88)％](P균＜0.05).여정상체질량조상비,초중조화비반조중TG、SBP、FPG명현증고[초중조、비반조화정상체질량조TG분별위(2.23±1.66)、(2.52±1.57)、(1.63±1.45) mmol/L(P균＜0.05),SBP분별위(127.77±19.07)、(137.52±16.98)(125.56±20.30)mmHg(P균＜0.05),FPG분별위(6.32±1.57)、(6.56±1.75) (5.86±1.32) mmol/L(P균＜0.05)];비반조화정상체질량조LDL-C분별위(5.05±0.83)、(3.08±0.96) mmol/L,DBP분별위(86.64±10.49)、(77.69±13.20) mmHg,hs-CRP분별위(3.74±5.51)、(2.33±4.67) mg/L,량조비교차이균유통계학의의(P균＜0.05);초중、비반조SOD명현감저[초중조、비반조화정상체중조SOD분별위(140.82±13.16)、(144.89±13.82)、(148.64±14.94) U/L(P균＜0.05)];여비반조비교,초중조SBP、DBP、hs-CRP명현강저[초중조SBP:(127.77±19.07) mmHg、DBP:(80.87±12.21) mmHg,hs-CRP:(2.31±3.73) mg/L](P균＜0.05).대사지표중TG、SBP、DBP、FPG、CRP、hs-CRP여FVC정부상관,상관계수의차위-0.129、-0.129、-0.136、-0.180、-0.220、-0.217(P＜0.05혹P＜0.01).SBP、FPG、CRP、hs-CRP여FEV1정부상관,상관계수의차위-0.128、-0.127、-0.148、-0.198(P＜0.05혹P＜0.01).SBP、CRP、hs-CRP여PEF정부상관,상관계수의차위-0.137、-0.117、-0.133(P균＜0.05).hs-CRP、SBP여MEF50정부상관,상관계수의차위-0.126、-0.124(P균＜0.05).SOD여FVC、PEF、FEV1/FEV、MEF50균정정상관,상관계수의차위0.149、0.119、0.141、0.129(P＜0.05혹P＜0.01).결론 비반도치폐공능수손반대사문란.대사지표여폐공능상관.
    Objective To investigate the relationship of pulmonary function and metabolic indexes in overweight as well as obesity people.Methods Three hundred and five health examination adults were selected as our subjects.The basic parameters,metabolic indexes and pulmonary function were measured.Of which,pulmonary function indexes include forced vital capacity (FVC),forced expiratory volume in one(FEV1),peak expiratory flow(PEF),the ratio of the forced expiratory volume in the first one second to the forced vital capacity (FEV1/FVC),the ratio of the forced expiratory volume in the first one second to the vital capacity(FEV1/VC),maximal expiratory flow after 50％ of the FVC (MEF50),maximal expiratory flow after 25％ of the FVC (MEF25),and each index value of lung function was expressed the ratio of the measured value/the predictive value.Metabolic indexes include triglycerides (TG),total cholesterol (TC),low-density lipoprotein cholesterol (LDL-C),fasting plasma glucose (FPG)),C-reactive protein (CRP),high-sensitivity C-reactive (hs-CRP),superoxide dismutase(SOD),systoloc blood pressure (SBP) and diastolic blood pressure (DBP).Statistical analysis methods include one-way analysis of variance and Spearman correlation analysis.Results The levels of FVC,FEV1,FEV1/FVC in overweight and the obesity group were (85.74 ± 13.94)％ and (82.85±13.34)％,(84.52 ± 14.62)％ and (82.74 ± 14.18)％,(103.40 ± 13.05)％ and (103.17 ±8.99)％respectively,lower than that of normal weight group [(95.79 ± 26.83) ％,(92.65 ± 26.93) ％,(99.98± 11.88) ％,all P values less than 0.05)].Compared with the normal weight group,the levels of TG,SBP,FPG in overweight group and the obesity group were significantly increased.The levels of LDL-C,DBP,hs-CRP in obesity were (5.05 ± 0.83) rmtmol/L,(86.64 ± 10.49) mmHg,(3.74 ± 5.51) mg/L respectively,higher than that of normal group [(3.08 ±0.96) mmol/L,(77.69 ± 13.20) mmHg,(2.33 ±4.67) mg/L,P ＜0.05)].SOD activities in overweight and obesity group were (140.82 ± 13.16),(144.89 ± 13.82) U/L respectively,significantly lower than that of normal weight group[(148.64 ± 14.94) U/L,P ＜0.05)).The levels of SBP,DBP,hs-CRP in the over weight group were (127.77 ± 19.07) mmHg,(80.87 ± 12.21) mmHg,(2.31± 3.73) mg/L),higher than that of obesity group.Among metabolic indices,TG,SBP,DBP,FBG,CRP,hs-CRP and SOD were related with FVC (r =-0.129,-0.129,-0.136,-0.180,-0.220,-0.217 respectively,P ＜ 0.05 or P ＜ 0.01).There was negatively correlated relationship between SBP,FBG,CRP,hs-CRP and FEV1 (r =-0.128,-0.127,-0.148,-0.198 respectively,P ＜0.05 or P ＜0.01),So were SBP,CRP,hs-CRP and PEF (r =-0.137,-0.117,-0.133 respectively,P ＜ 0.05).Negatively correlated relationship between hsCRP,SBP and MEF50 were seen (r =-0.126,-0.124,P ＜ 0.05).Meanwhile there was negatively correlated relationship between SOD and FVC,FEV1/FEV,PEF,MEF50 (r =0.149,0.094,0.119,0.141,0.129respectively,P ＜ 0.05 or P ＜ 0.01).Conclusion Impaired pulmonary function and metabolic disorders were showed in the overweight and obesity people.Metabolic indexes were related with pulmonary function.
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