中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
2期
118-121
,共4页
稳定型心绞痛%髓过氧化物酶%超敏C反应蛋白%主要心血管不良事件
穩定型心絞痛%髓過氧化物酶%超敏C反應蛋白%主要心血管不良事件
은정형심교통%수과양화물매%초민C반응단백%주요심혈관불량사건
Stable angina pectoris%Plasma myeloperoxidase%High-sensitivity C-reactive protein%Adverse cardiovascular events
目的 探讨血浆髓过氧化物酶(MPO)对稳定型心绞痛患者远期心脏事件的预测作用.方法 选择稳定型心绞痛患者247例,分别检测血浆MPO、超敏C反应蛋白(hs-CRP),随访2年,观察不同血浆MPO水平患者冠心病(冠状动脉狭窄＞50％)主要心血管不良事件(MACES,包括死亡、心肌梗死、卒中等)的发生情况.结果 247例患者按血浆MPO水平行二分位数法分组分为MPO＞ 320 mg/L组84例和MPO≤320 mg/L组163例,血浆MPO＞ 320 mg/L者MACES发生风险明显增加(HR=1.67,95％ CI:1.32～2.57,P＜0.05).血浆MPO与hs-CRP浓度成正相关(r=0.132,P＜0.05).结论 血浆MPO浓度能在稳定型心绞痛患者中独立预测长期主要心血管不良事件的发生,在预测主要心血管不良事件发生的风险因子中,hs-CRP与血浆MPO浓度存在相关性.
目的 探討血漿髓過氧化物酶(MPO)對穩定型心絞痛患者遠期心髒事件的預測作用.方法 選擇穩定型心絞痛患者247例,分彆檢測血漿MPO、超敏C反應蛋白(hs-CRP),隨訪2年,觀察不同血漿MPO水平患者冠心病(冠狀動脈狹窄＞50％)主要心血管不良事件(MACES,包括死亡、心肌梗死、卒中等)的髮生情況.結果 247例患者按血漿MPO水平行二分位數法分組分為MPO＞ 320 mg/L組84例和MPO≤320 mg/L組163例,血漿MPO＞ 320 mg/L者MACES髮生風險明顯增加(HR=1.67,95％ CI:1.32～2.57,P＜0.05).血漿MPO與hs-CRP濃度成正相關(r=0.132,P＜0.05).結論 血漿MPO濃度能在穩定型心絞痛患者中獨立預測長期主要心血管不良事件的髮生,在預測主要心血管不良事件髮生的風險因子中,hs-CRP與血漿MPO濃度存在相關性.
목적 탐토혈장수과양화물매(MPO)대은정형심교통환자원기심장사건적예측작용.방법 선택은정형심교통환자247례,분별검측혈장MPO、초민C반응단백(hs-CRP),수방2년,관찰불동혈장MPO수평환자관심병(관상동맥협착＞50％)주요심혈관불량사건(MACES,포괄사망、심기경사、졸중등)적발생정황.결과 247례환자안혈장MPO수평행이분위수법분조분위MPO＞ 320 mg/L조84례화MPO≤320 mg/L조163례,혈장MPO＞ 320 mg/L자MACES발생풍험명현증가(HR=1.67,95％ CI:1.32～2.57,P＜0.05).혈장MPO여hs-CRP농도성정상관(r=0.132,P＜0.05).결론 혈장MPO농도능재은정형심교통환자중독립예측장기주요심혈관불량사건적발생,재예측주요심혈관불량사건발생적풍험인자중,hs-CRP여혈장MPO농도존재상관성.
Objective To explore the independent prognostic value of plasma myeloperoxidase (MPO) in cardiovascular event of patient with stable angina pectoris.Methods Two hundred and forty-seven patients with stable angina pectoris (defined as 50％ stenosis in any coronary vessel) were selected as our subjects and they all were followed up for 2 years.Plasma MPO and hsCRP concentrations were measured.The major adverse cardiovascular events (MACEs),including death,myocardial infarction and stroke,occurred in patients were recorded.Results All patients were divided into high MPO group (84 cases and plasma MPO concentrations over 320 mg/L) and low MPO group (163 cases,plasma MPO concentrations less than 320 mg/L).Compared with patients in low MPO group,the risk of occurring MACEs in high MPO group was higher(HR =1.67,95％ CI =1.32-2.57,P ＜ 0.05).There was positive correlation between plasma MPO and hsCRP concentrations (r =0.132,P ＜ 0.05).Conclusion MPO level may serve as a better prediction index for adverse cardiovascular events of patients with Stable angina pectorisindependently.MPO has relationship with hsCRP concentrations.
