CAJ | 학술논문

目的探讨注射用阿魏酸钠对高原慢性肺源性心脏病(肺心病)患者急性加重期高凝状态的影响.方法 41例慢性肺心病急性加重期患者,随机分为治疗组22例,对照组19例.两组患者均给予常规抗感染、祛痰止咳、纠正水电解质紊乱、持续低流量吸氧、超声雾化吸入治疗.治疗组静脉滴注阿魏酸钠300 mg,1次/d治疗,2周为1疗程.治疗前后检查血流变、肝肾功能.结果治疗组治疗后与治疗前比较,全血高切黏度[(4.91±1.60)、(5.78±1.65) mPa·s,P=0.042]、血浆黏度[(1.56±0.49)、(1.87±0.65) mPa·s,P=0.041]明显下降.对照组上述指标治疗前后差异均无统计学意义(P均＞0.05).两组治疗后肝肾功能无异常变化.结论阿魏酸钠对高原慢性肺心病急性加重期患者血液高凝状态的治疗有效.
목적 탐토주사용아위산납대고원만성폐원성심장병(폐심병)환자급성가중기고응상태적영향.방법 41례만성폐심병급성가중기환자,수궤분위치료조22례,대조조19례.량조환자균급여상규항감염、거담지해、규정수전해질문란、지속저류량흡양、초성무화흡입치료.치료조정맥적주아위산납300 mg,1차/d치료,2주위1료정.치료전후검사혈류변、간신공능.결과 치료조치료후여치료전비교,전혈고절점도[(4.91±1.60)、(5.78±1.65) mPa·s,P=0.042]、혈장점도[(1.56±0.49)、(1.87±0.65) mPa·s,P=0.041]명현하강.대조조상술지표치료전후차이균무통계학의의(P균＞0.05).량조치료후간신공능무이상변화.결론 아위산납대고원만성폐심병급성가중기환자혈액고응상태적치료유효.
Objective To explore the effects of Sodium Ferulateon treating patients with plateau derived chronic cor pulmonale in acute ecacerbation phase at high altitude.Methods Forty-one cases with plateau derived chronic cor pulmonale were randomly divided into treatment group (22 cases) and control group (19 cases).All the patients in the two groups were given the same routine treatments including anti-infection,expectorant,balancing hydro-electrolytic discord,persistent inspiration of low-flow oxygen and inhalation by ultrasonic nebulization.Patients in treatment group were plus given the Sodium Ferulate at dose of 300 mg by intravenous drop once daily for 2 weeks.Hemorrheology,hepatic and renal function were examined.Results After treatment,the level of whole blood viscosity and plasma viscosity in treatment group were (4.91 ± 1.60) mPa · s and (1.56 ± 0.49) mPa · s,lower than that before treatment ((5.78 ± 1.65) mPa · s and (1.87 ± 0.65) mPa · s,P =0.042,0.041).There were no significant difference in the control group in terms of whole blood viscosity and plasma viscosity.There was not abnormal change of hepatic and renal function of two groups after treatment.Conclusion Sodium Ferulate therapy was effective to treatment of the plateau derived chronic cor pulmonale in acute ecacerbation phase.