中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
8期
797-800
,共4页
李晋梅%李芳菲%李鑫%冯涛
李晉梅%李芳菲%李鑫%馮濤
리진매%리방비%리흠%풍도
帕金森病%异动症%左旋多巴
帕金森病%異動癥%左鏇多巴
파금삼병%이동증%좌선다파
Parkinson's disease%Dyskinesias%Levodopa
目的 研究帕金森病患者发生异动症的危险因素.方法 筛选符合英国脑库帕金森病诊断标准并且应用左旋多巴制剂至少1个月的患者,根据异动症临床定义判断有无异动症分为异动和非异动两组.比较两组患者在性别、年龄、发病年龄、病程、体质量、UPDRS运动量表评分等临床参数以及左旋多巴最大日剂量、累计左旋多巴用药时间、单位体质量左旋多巴用量等治疗参数方面上有无差异,并用logistic多因素回归分析异动症的独立危险因素.再根据剂末现象合并异动症与否分为两组,比较两组在上述各参数方面有无差异.结果 142例患者中有11例存在异动症(11/142,7.8％),其中,剂峰异动9例,合并剂末异动的2例.异动组与非异动组在性别、体质量、左旋多巴最大日剂量和单位体质量左旋多巴用量方面差异有统计学意义(P均＜0.05).剂末现象合并异动症与剂末现象不合并异动症比较,性别、体质量、单位体质量左旋多巴用量方面差异均有统计学意义(P均＜ 0.05).logistic多因素回归分析异动症的独立危险因素是单位体质量左旋多巴用量(OR=1.846,95％CI:1.234～2.762,P =0.003)和左旋多巴最大日剂量(OR=0.991,95％ CI:0.984～0.999,P=0.033).结论 帕金森病发生异动症的危险因素有多种,其中独立危险因素是左旋多巴最大日剂量和单位体质量左旋多巴用量.
目的 研究帕金森病患者髮生異動癥的危險因素.方法 篩選符閤英國腦庫帕金森病診斷標準併且應用左鏇多巴製劑至少1箇月的患者,根據異動癥臨床定義判斷有無異動癥分為異動和非異動兩組.比較兩組患者在性彆、年齡、髮病年齡、病程、體質量、UPDRS運動量錶評分等臨床參數以及左鏇多巴最大日劑量、纍計左鏇多巴用藥時間、單位體質量左鏇多巴用量等治療參數方麵上有無差異,併用logistic多因素迴歸分析異動癥的獨立危險因素.再根據劑末現象閤併異動癥與否分為兩組,比較兩組在上述各參數方麵有無差異.結果 142例患者中有11例存在異動癥(11/142,7.8％),其中,劑峰異動9例,閤併劑末異動的2例.異動組與非異動組在性彆、體質量、左鏇多巴最大日劑量和單位體質量左鏇多巴用量方麵差異有統計學意義(P均＜0.05).劑末現象閤併異動癥與劑末現象不閤併異動癥比較,性彆、體質量、單位體質量左鏇多巴用量方麵差異均有統計學意義(P均＜ 0.05).logistic多因素迴歸分析異動癥的獨立危險因素是單位體質量左鏇多巴用量(OR=1.846,95％CI:1.234～2.762,P =0.003)和左鏇多巴最大日劑量(OR=0.991,95％ CI:0.984～0.999,P=0.033).結論 帕金森病髮生異動癥的危險因素有多種,其中獨立危險因素是左鏇多巴最大日劑量和單位體質量左鏇多巴用量.
목적 연구파금삼병환자발생이동증적위험인소.방법 사선부합영국뇌고파금삼병진단표준병차응용좌선다파제제지소1개월적환자,근거이동증림상정의판단유무이동증분위이동화비이동량조.비교량조환자재성별、년령、발병년령、병정、체질량、UPDRS운동량표평분등림상삼수이급좌선다파최대일제량、루계좌선다파용약시간、단위체질량좌선다파용량등치료삼수방면상유무차이,병용logistic다인소회귀분석이동증적독립위험인소.재근거제말현상합병이동증여부분위량조,비교량조재상술각삼수방면유무차이.결과 142례환자중유11례존재이동증(11/142,7.8％),기중,제봉이동9례,합병제말이동적2례.이동조여비이동조재성별、체질량、좌선다파최대일제량화단위체질량좌선다파용량방면차이유통계학의의(P균＜0.05).제말현상합병이동증여제말현상불합병이동증비교,성별、체질량、단위체질량좌선다파용량방면차이균유통계학의의(P균＜ 0.05).logistic다인소회귀분석이동증적독립위험인소시단위체질량좌선다파용량(OR=1.846,95％CI:1.234～2.762,P =0.003)화좌선다파최대일제량(OR=0.991,95％ CI:0.984～0.999,P=0.033).결론 파금삼병발생이동증적위험인소유다충,기중독립위험인소시좌선다파최대일제량화단위체질량좌선다파용량.
Objective To explore the risk factors of dyskinesias in Parkinson' s disease (PD) patients.Methods Patients with PD who had taken levodopa at least 1 month were recruited according to the United Kingdom Brain Bank (UKBB) Criteria..All patients were divided into dyskinesias group and non-dyskinesias group according to the clinical definition of dyskinesia.The parameters including gender,age,age onset,duration,body weight,UPDRS scale score,and treatment parameter,such as the maximum daily dose of levodopa,the cumulative time of medication of levodopa,levodopa dose per weight of patients with dyskinesias were recorded.Multivariate logistic regression analysis was used to analyze risk factors of dyskinesias.The patients were divided into dyskinesias and no dyskinesias groups based on presence of motor complications.Results The incidence rate of dyskinesias was 7.8％ (11/142) in all 142 patients.Of which,9 cases were with peak-dose dyskinesia,and 2 cases with both wearing-off and dyskinesia.There were statistically significant difference between dyskinesias group and non-dyskinesias group in terms of sex,weight,the maximum daily dose of levodopa and levodopa dose per weight(P ＜ 0.05).The same results appeared between wearing-off group and wearing-off with dyskinesia group (P ＜ 0.05).Multivariate Logistic regression analysis showed that total dose of levodopa(OR =1.846,95％ CI:1.234-2.762,P =0.003) and levodopa dose per weight were independentriskfactors(OR=0.991,95％CI:0.984-0.999,P=0.033).Conclusion The risk factors of dyskinesias in Parkinson's disease is closely linked to total dose of levodopa and levodopa dose per weight.
