中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2014年
10期
1030-1032
,共3页
朱洁莹%刘丽军%信栓力%常超%李敏%王桂东%李琴%李雅琪%魏金花
硃潔瑩%劉麗軍%信栓力%常超%李敏%王桂東%李琴%李雅琪%魏金花
주길형%류려군%신전력%상초%리민%왕계동%리금%리아기%위금화
冠心病%心绞痛%肿瘤坏死因子α%超敏C反应蛋白
冠心病%心絞痛%腫瘤壞死因子α%超敏C反應蛋白
관심병%심교통%종류배사인자α%초민C반응단백
Coronary heart disease%Angina pectoris%Tumor necrosis factorα%C-reactive protein
目的 探讨肿瘤坏死因子α(TNF-α)及超敏C反应蛋白(hs-CRP)在冠心病心绞痛发病机制中的作用.方法 选择冠状动脉造影确诊的心绞痛患者90例,分为不稳定型心绞痛(UAP)组46例,稳定型心绞痛(SAP)组44例;30例冠状动脉造影正常者作为对照组.采用酶联免疫吸附(ELISA)法检测血浆TNF-α、免疫浊度法检测hs-CRP浓度.结果 UAP组血浆TNF-α、hs-CRP水平为(34.87±9.59)ng/L、(2.34±0.81) mg/L,显著高于SAP组的(25.39±7.68) ng/L和(1.79±0.59) mg/L(P均＜0.01),均明显高于对照组(13.87±5.24) ng/L、(1.15±0.35) mg/L(P均＜0.01).结论 炎症反应可能参与了冠心病的发病过程,血浆TNF-α与hs-CRP对预测冠心病心绞痛的存在和发展有重要的临床意义.
目的 探討腫瘤壞死因子α(TNF-α)及超敏C反應蛋白(hs-CRP)在冠心病心絞痛髮病機製中的作用.方法 選擇冠狀動脈造影確診的心絞痛患者90例,分為不穩定型心絞痛(UAP)組46例,穩定型心絞痛(SAP)組44例;30例冠狀動脈造影正常者作為對照組.採用酶聯免疫吸附(ELISA)法檢測血漿TNF-α、免疫濁度法檢測hs-CRP濃度.結果 UAP組血漿TNF-α、hs-CRP水平為(34.87±9.59)ng/L、(2.34±0.81) mg/L,顯著高于SAP組的(25.39±7.68) ng/L和(1.79±0.59) mg/L(P均＜0.01),均明顯高于對照組(13.87±5.24) ng/L、(1.15±0.35) mg/L(P均＜0.01).結論 炎癥反應可能參與瞭冠心病的髮病過程,血漿TNF-α與hs-CRP對預測冠心病心絞痛的存在和髮展有重要的臨床意義.
목적 탐토종류배사인자α(TNF-α)급초민C반응단백(hs-CRP)재관심병심교통발병궤제중적작용.방법 선택관상동맥조영학진적심교통환자90례,분위불은정형심교통(UAP)조46례,은정형심교통(SAP)조44례;30례관상동맥조영정상자작위대조조.채용매련면역흡부(ELISA)법검측혈장TNF-α、면역탁도법검측hs-CRP농도.결과 UAP조혈장TNF-α、hs-CRP수평위(34.87±9.59)ng/L、(2.34±0.81) mg/L,현저고우SAP조적(25.39±7.68) ng/L화(1.79±0.59) mg/L(P균＜0.01),균명현고우대조조(13.87±5.24) ng/L、(1.15±0.35) mg/L(P균＜0.01).결론 염증반응가능삼여료관심병적발병과정,혈장TNF-α여hs-CRP대예측관심병심교통적존재화발전유중요적림상의의.
Objective To explore the role of tumor necrosis factor a(TNF-α) and high sensitive Creactive protein (hsCRP) in mechanism of patients with coronary heart disease (CHD).Methods Ninety patients with diagnosed as angina pectoris by coronary angiography were selected our subjects.Among which,there were 46 cases with unstable angina pectoris (UAP group),44 cases with stable angina patients (SAP group).At the same time,30 cases with normal coronary angiography were selected and as control group.The level of TNF-α were measured by enzyme-linked immunosorbent assay,and the level of hsCRP was measured by immuno-nephelometry.Results The average plasma levels of TNF-α and hsCRP were (34.87 ± 9.59) ng/L,(2.34±0.81) mg/L in UAP group,significantly higher than those of SAP group ((25.39 ±7.68) ng/L,(1.79 ±0.59) mg/L; P ＜0.01),and both were higher than those of control group ((13.87 ± 5.24) nig/L,(1.15 ±0.35) mg/L;P ＜0.01).Conclusion Inflammatory might play an important role in the pathogenesis of CHD,and TNF-α and Hs-CRP show the significance in predicting occurrence of angina pectoris and development of CHD.
