中华病理学杂志
中華病理學雜誌
중화병이학잡지
Chinese Journal of Pathology
2013年
12期
801-805
,共5页
李忠武%王燕%薛卫成%斯璐%崔传亮%曹登峰%周立新%郭军%陆爱萍
李忠武%王燕%薛衛成%斯璐%崔傳亮%曹登峰%週立新%郭軍%陸愛萍
리충무%왕연%설위성%사로%최전량%조등봉%주립신%곽군%륙애평
黑色素瘤%免疫组织化学%预后
黑色素瘤%免疫組織化學%預後
흑색소류%면역조직화학%예후
Melanoma%Immunohistochemistry%Prognosis
目的 探讨galectin-1和galectin-3在不同黑色素细胞病变中的表达及其临床预后意义.方法 应用组织芯片及免疫组织化学EnVision法检测galectin-1和galectin-3在39例良性皮肤痣、58例皮肤原发恶性黑色素瘤、24例黏膜原发恶性黑色素瘤、77例转移性黑色素瘤中的表达.结果 galeetin-1和galeetin-3在良性皮肤痣中的表达均高于皮肤原发恶性黑色素瘤、黏膜原发恶性黑色素瘤及转移性黑色素瘤(均P＜0.01).galectin-3在皮肤原发恶性黑色素瘤胞核中的表达高于黏膜原发恶性黑色素瘤(P＜0.01)及转移性黑色素瘤(P＜0.01),并与患者年龄、肿瘤组织坏死状态相关(P＜0.05);生存及预后分析显示,Clark分级与皮肤原发恶性黑色素瘤患者总生存时间相关(P=0.037).galectin-3在所有黑色素瘤病例瘤细胞核内的表达水平与TNM分期是影响患者总生存时间的相关因素(P＜0.01),但只有TNM分期是独立预后因素.结论 galectin-1和galectin-3在黑色素瘤中表达下降;galectin-3在胞核内的表达下降,可能预示黑色素瘤预后不良.
目的 探討galectin-1和galectin-3在不同黑色素細胞病變中的錶達及其臨床預後意義.方法 應用組織芯片及免疫組織化學EnVision法檢測galectin-1和galectin-3在39例良性皮膚痣、58例皮膚原髮噁性黑色素瘤、24例黏膜原髮噁性黑色素瘤、77例轉移性黑色素瘤中的錶達.結果 galeetin-1和galeetin-3在良性皮膚痣中的錶達均高于皮膚原髮噁性黑色素瘤、黏膜原髮噁性黑色素瘤及轉移性黑色素瘤(均P＜0.01).galectin-3在皮膚原髮噁性黑色素瘤胞覈中的錶達高于黏膜原髮噁性黑色素瘤(P＜0.01)及轉移性黑色素瘤(P＜0.01),併與患者年齡、腫瘤組織壞死狀態相關(P＜0.05);生存及預後分析顯示,Clark分級與皮膚原髮噁性黑色素瘤患者總生存時間相關(P=0.037).galectin-3在所有黑色素瘤病例瘤細胞覈內的錶達水平與TNM分期是影響患者總生存時間的相關因素(P＜0.01),但隻有TNM分期是獨立預後因素.結論 galectin-1和galectin-3在黑色素瘤中錶達下降;galectin-3在胞覈內的錶達下降,可能預示黑色素瘤預後不良.
목적 탐토galectin-1화galectin-3재불동흑색소세포병변중적표체급기림상예후의의.방법 응용조직심편급면역조직화학EnVision법검측galectin-1화galectin-3재39례량성피부지、58례피부원발악성흑색소류、24례점막원발악성흑색소류、77례전이성흑색소류중적표체.결과 galeetin-1화galeetin-3재량성피부지중적표체균고우피부원발악성흑색소류、점막원발악성흑색소류급전이성흑색소류(균P＜0.01).galectin-3재피부원발악성흑색소류포핵중적표체고우점막원발악성흑색소류(P＜0.01)급전이성흑색소류(P＜0.01),병여환자년령、종류조직배사상태상관(P＜0.05);생존급예후분석현시,Clark분급여피부원발악성흑색소류환자총생존시간상관(P=0.037).galectin-3재소유흑색소류병례류세포핵내적표체수평여TNM분기시영향환자총생존시간적상관인소(P＜0.01),단지유TNM분기시독립예후인소.결론 galectin-1화galectin-3재흑색소류중표체하강;galectin-3재포핵내적표체하강,가능예시흑색소류예후불량.
Objective To study the expression and prognostic significance of galectin-1 and galectin-3 in different melanocytic lesions.Methods The expression of galectin-1 and galectin-3 in 39 cases of benign nevus,58 cases of primary cutaneous melanoma,24 cases of primary mucosal melanoma,69 cases of melanoma with lymph node metastasis and 8 cases of melanoma with distant metastasis were studied by immunohistochemistry and tissue microarray.Results The expression of galectin-1 and galectin-3 was higher in benign nevi than in melanomas (P ＜ 0.01).The nuclear expression of galectin-3 was higher in primary cutaneous melanomas than in primary mucosal melanomas or melanomas with metastases (P ＜ 0.01,respectively).The expression correlated with age of patients (P ＜0.05),necrosis (P ＜0.05) and survival time (P ＜0.01).Clark's level also correlated with survival time in patients with cutaneous melanomas (P =0.037).TNM staging was the only independent prognostic factor for melanomas (P ＜ 0.01).Conclusions The expression of galectin-1 and galectin-3 is decreased in melanomas.The decrease in nuclear expression of galectin-3 may represent a poor prognostic factor for melanomas.TNM staging is an independent prognostic factor which influences the survival time.
