中华病理学杂志
中華病理學雜誌
중화병이학잡지
Chinese Journal of Pathology
2014年
3期
169-172
,共4页
赵赋%张晶%王兴朝%王振民%汪颖%渠沛然%罗麟%刘丕楠
趙賦%張晶%王興朝%王振民%汪穎%渠沛然%囉麟%劉丕楠
조부%장정%왕흥조%왕진민%왕영%거패연%라린%류비남
髓母细胞瘤%年龄分布%肿瘤,组织学类型%预后
髓母細胞瘤%年齡分佈%腫瘤,組織學類型%預後
수모세포류%년령분포%종류,조직학류형%예후
Medulloblastoma%Age distribution%Neoplasms by histologic type%Prognosis
目的 探讨成人髓母细胞瘤(MB)不同病理学亚型的临床特点及预后.方法 回顾性分析2000年6月至2012年6月151例成人MB的临床资料、影像学和病理学表现,采用x2检验对各亚型临床特征进行分析,Kaplan-Meier生存分析对各亚型生存期进行比较.结果 151例MB包括经典型73例,促纤维增生/结节型36例,间变型39例,大细胞型3例;其中促纤维增生/结节型较其他亚型更常见于小脑半球(P=0.000),间变型和大细胞型较其他亚型更容易复发(P=0.000)及转移(P=0.003);至随访期结束无瘤生存患者91例,带瘤生存15例,死亡45例,生存时间为6 ～ 150个月,平均生存时间(103.3±5.7)个月(95％ CI 92.52 ～ 115.09);其中经典型组、促纤维增生/结节型组、间变型和大细胞型组平均生存期分别为(110.7 ±7.8)、(125.5 ±7.6)和(57.6±7.6)个月,差异具有统计学意义(P =0.000).结论 成人MB各个病理亚型具有不同临床特点,而间变型和大细胞型成人MB患者预后不良.
目的 探討成人髓母細胞瘤(MB)不同病理學亞型的臨床特點及預後.方法 迴顧性分析2000年6月至2012年6月151例成人MB的臨床資料、影像學和病理學錶現,採用x2檢驗對各亞型臨床特徵進行分析,Kaplan-Meier生存分析對各亞型生存期進行比較.結果 151例MB包括經典型73例,促纖維增生/結節型36例,間變型39例,大細胞型3例;其中促纖維增生/結節型較其他亞型更常見于小腦半毬(P=0.000),間變型和大細胞型較其他亞型更容易複髮(P=0.000)及轉移(P=0.003);至隨訪期結束無瘤生存患者91例,帶瘤生存15例,死亡45例,生存時間為6 ～ 150箇月,平均生存時間(103.3±5.7)箇月(95％ CI 92.52 ～ 115.09);其中經典型組、促纖維增生/結節型組、間變型和大細胞型組平均生存期分彆為(110.7 ±7.8)、(125.5 ±7.6)和(57.6±7.6)箇月,差異具有統計學意義(P =0.000).結論 成人MB各箇病理亞型具有不同臨床特點,而間變型和大細胞型成人MB患者預後不良.
목적 탐토성인수모세포류(MB)불동병이학아형적림상특점급예후.방법 회고성분석2000년6월지2012년6월151례성인MB적림상자료、영상학화병이학표현,채용x2검험대각아형림상특정진행분석,Kaplan-Meier생존분석대각아형생존기진행비교.결과 151례MB포괄경전형73례,촉섬유증생/결절형36례,간변형39례,대세포형3례;기중촉섬유증생/결절형교기타아형경상견우소뇌반구(P=0.000),간변형화대세포형교기타아형경용역복발(P=0.000)급전이(P=0.003);지수방기결속무류생존환자91례,대류생존15례,사망45례,생존시간위6 ～ 150개월,평균생존시간(103.3±5.7)개월(95％ CI 92.52 ～ 115.09);기중경전형조、촉섬유증생/결절형조、간변형화대세포형조평균생존기분별위(110.7 ±7.8)、(125.5 ±7.6)화(57.6±7.6)개월,차이구유통계학의의(P =0.000).결론 성인MB각개병리아형구유불동림상특점,이간변형화대세포형성인MB환자예후불량.
Objective To study the pathologic characteristics and prognosis in different subtypes of adult medulloblastoma (MB).Methods The clinical information,imaging findings and pathologic characteristics of 151 cases of adult medulloblastomas were retrospectively reviewed and analyzed by chi-square test.The survival data were assessed using the Kaplan-Meier method.Results Amongst the 151 MB cases studied,there were 73 cases of classic MB,36 cases of desmoplastic/nodular MB,39 cases of anaplastic MB and 3 cases of large cell MB.The primary tumors were more frequently located in cerebral hemisphere in desmoplastic/nodular MB than in other subtypes (P =0.000).On the other hand,large cell/ anaplastic MB were associated with more frequently local recurrence and distant metastasis (P =0.003).The post-operative overall survival time ranged from 6 to 150 months,with median survival being (103.3 ± 5.7) months (95％ CI,92.52 to 115.09).The median survival of classic MB,desmoplastic/nodular MB and large cell/anaplastic MB was (110.7 ± 7.8) months,(125.5 ± 7.6) months and (57.6 ± 7.6) months,respectively.The differences were statistically significant (P =0.000).Conclusions The three variants of MB show different biologic behavior.Large cell/anaplastic MB represents an independent poor prognostic indicator in adults.
